You may want to add PYCNOGENOL. 50 mg three times a day to your supplement list.
It also lowers MMP-9s. raises HDL and helps control diabetis(sic) prvents blindness, treats hemmeroids etc etc etc lots more info on PubMed and Medlars(plus)
Phytomedicine. 2000 Oct;7(5):383-8.
PYCNOGENOL in chronic venous insufficiency.
Petrassi C, Mastromarino A, Spartera C.
Cattedra e Scuola di Specializzazione in Chirurgia Vascolare, Dipartimento di Scienze Chirurgiche, Università degli Studi di L'Aquila, Italy. email@example.com
The aim of out study was to investigate the efficacy of Pycnogenol - a French maritime pine bark extract - in the treatment of chronic venous insufficiency (CVI).
The study consisted of a double-blind phase - in which 20 patients were recruited and randomly treated with placebo or Pycnogenol (100 mg 2 3/day for 2 months) - and an open phase - in which other 20 patients were treated with Pycnogenol at the same dose schedule. In total, 40 patients were enrolled; 30 of them were treated with Pycnogenol and 10 with placebo.
Pycnogenol significantly improved the legs' heaviness and subcutaneous edema; the venous pressure was also significantly reduced by the Pycnogenol treatment, thus adding further clinical evidence to its therapeutic efficacy in patients with CVI.
Pycnogenol was effective, probably by either stabilizing the collagenous subendothelial basal membrane or scavenging the free radicals, or by a combination of these activities.
Clinically, capillary leakage, perivascular inflammation and subcutaneous edema were all reduced.
The safety of use of Pycnogenol is demonstrated by the lack of side effects or changes in blood biochemistry and hematologic parameters.
Pycnogenol can be therefore recommended both for prevention and treatment of CVI and related veno-capillary disturbances.
PMID: 11081989 [PubMed - indexed for MEDLINE]