all things vitamin D

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Postby CureOrBust » Sat Jan 31, 2009 5:08 am

sorry if you misunderstood me patientx, I was asking about if there was any published peer reviewed articles supporting Marshals claims. :oops:

Actually, reading Furch's previous post, there are no published articles specifically supporting the claims of Marshal.
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Postby patientx » Sat Jan 31, 2009 9:06 am

Sorry about the confusion, Cure. My last post was a response to Furch. The link to Perlmutter's article he posted refers to Srirams's orginal 1999 article on C. Pneumonaie and MS.

But, I agree; I haven't come across any journal articles supporting Marshall's claims.
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Postby MacKintosh » Sat Jan 31, 2009 3:03 pm

Patientx, I'm with you; I'm one of the veterans of the Marshall, or Wheldon, antibiotic protocol, and I supplement with 8,000 - 10,000 iu of Vitamin D3 daily. By my reckoning, I'm 98% recovered from my major MS downhill slide, and I know I can feel like dog food when I let my D3 slip.

D3 has been implicated in cancer prevention and in improving many so-called 'autoimmune' conditions. I will never let my levels slide again. On CPn Help.org (the name gets truncated by the editors of this website, so you need to search for it) dot org, we have a couple of hot topics on all the latest Vitamin D research, so you guys might want to do a quick search over there.

Furch, you need to start a new topic, or find an old topic on the MP, rather than continue this conversation here. Bottom line, the MP uses subclinical doses of antibiotics, which, in itself, is dangerous and provokes resistance. That closes the case on the MP for me.
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HLA-DRB1 gene and Vitamin D....The cause?

Postby cheerleader » Wed Feb 04, 2009 4:16 pm

Edited for Bob.....Here's the Abstract-
Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D


Researchers at Oxford believe they have found the cause of MS. Lack of vitamin D during childhood modifies a the DRB-1 gene....
The Oxford team have shown for the first time that vitamin D interacts directly with a gene, DRB1, which increases the risk of MS threefold. Proof of this has been obtained by infecting human cells with a short piece of DNA bearing the DRB1 gene and treating the cells with vitamin D. In this way the Oxford team were able to show that vitamin D stimulated the gene to work and express itself on the surface of the cell.

Other investigations by the Oxford team in collaboration with Canadian scientists have shown that MS is inherited preferentially through the female line as an “imprinted” gene. This explains why MS affects three or four women to every man.

It now seems likely that insufficient vitamin D is the crucial environmental factor that modifies the DRB1 gene into the imprinted form that causes MS and transmits it from one generation to the next. DRB1 is one of a family of HLA genes that code for structures on the surface of human white blood cells. And it is white blood cells that are involved in the “autoimmune” reaction that destroys the nervous system of MS sufferers.

The Oxford team believe that people with MS have white cells that are incorrectly programmed early in life. There are millions of different T-cells, a particular type of white cell produced in the thymus gland, each programmed to recognise and attack different types of invading bacteria and viruses. Ordinarily the T cells that might attack the body itself are deleted early in life in a stock-taking process. But this process can go wrong when certain genes that are normally masked by the imprinting process are mistakenly unmasked.

It appears that lack of vitamin D early in life impairs the ability of the thymus to delete these T cells and so they go on to mistakenly attack the body with what the Oxford team call “friendly fire”.


link

AC
Last edited by cheerleader on Wed Feb 04, 2009 10:39 pm, edited 1 time in total.
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby Loobie » Wed Feb 04, 2009 5:00 pm

All I've got to say is "whoa". It sounds pretty definitive?
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Postby Lyon » Wed Feb 04, 2009 5:05 pm

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Postby cheerleader » Wed Feb 04, 2009 5:33 pm

You're right, Bob- that was the last published study.
Looks like the Times is doing a series on MS and vitamin D before the release of the latest study to be published in Plos.

Here's another article from Gillie in which he quotes Ebers for the interview.

George Ebers, of Oxford University, told The Times that for the first time there was hard evidence directly relating both genes and the environment to the origins of MS. His work suggests that vitamin D deficiency during pregnancy and childhood may increase the risk of a child developing the disease.

He has also established the possiblity that genetic vulnerability to MS, apparently initiated by lack of vitamin D, may be passed on to subsequent generations.

These risks might plausibly be reduced to giving vitamin D supplements to pregnant woman and young children. “I think it offers the potential for treatment which might prevent MS in the future,” Professor Ebers said.

“Our research has married two key pieces of the puzzle. The interaction of vitamin D with the gene is very specific and it seems most unlikely to be a coincidence of any kind. Serious questions now arise over the wisdom of current advice to limit sun exposure and avoid sunbathing. We also need to give better advice and help to the public on vitamin D supplements, particularly pregnant and nursing mothers."


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Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby Lyon » Wed Feb 04, 2009 6:04 pm

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Postby Lyon » Wed Feb 04, 2009 6:50 pm

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Postby HUTTO » Wed Feb 04, 2009 7:13 pm

so how do you treat this?? this is great for my kids though. do we just supplement more vit d...mine was low again..taking 4000iu a day and at a 39...up from a 17 though..so cheer..bob...what do we do?? i have never seen an article that difinative..thanks for posting it.
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Postby cheerleader » Wed Feb 04, 2009 7:24 pm

Hey Hutto...
I've been giving my 14 year old 2,000IU of vitamin D daily for the last year. We live in southern Ca. and he's outside in the sun almost everyday...but he's fair, like his Dad (he's his mini-me) and wears sunscreen. I just think it's a good thing. Also a good idea for kids to eat healthy dairy products. Jeff takes 6,000IU vit. D a day and gets his sun.

I know Bob wants the study to back this up....so do I. Just thought it was interesting to post, as it looks like a roll-out preview to the Plos publication. I don't think Dr. Ebers would make such claims without science behind it...and I don't think the Times would print an "agenda" series on MS and vitamin D, invoking Oxford, without facts behind it. But I could be wrong....(it's happened once or twice before :wink: ) Once again, time will tell. Til then, nothing wrong with some vitamin D supplementation.

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Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby Lyon » Wed Feb 04, 2009 8:09 pm

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Postby cheerleader » Wed Feb 04, 2009 10:37 pm

Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby Lyon » Thu Feb 05, 2009 3:27 am

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Postby Loobie » Thu Feb 05, 2009 4:45 am

I've been pumping my kid with Vit. D since she was about 7 or 8 (she's almost 13 right now). I was listening to a Sunday morning local AM show on my way to racquetball one weekend morning when the guy on there was talking about how he doesn't get any of his family flu shots anymore. He said it was due to the high vitamin D levels they supplement with during the winter. And it's grey flannel skis here pretty much all winter so even when the kids play outside, there really isn't much sun normally. So my initial impetus to start pumping her full of it was motivated by that, but I'm glad I started doing it now. However, I quit using anything other than number 4 sunscreen on my daughter, and that's only at the beginning of summer. She's on the swimteam and stays dark brown all summer. I just read that abstract everytime I log on here (because it's right on the home page) about fathers being more likely to pass MS on to their kids. I take 4000 IU of it per day and my little one gets 2000. Last year I read a link someone posted about the sunbathing doctor in Australia who has MS. I tried it and I just tell you that while I couldn't see very well while in the sun, I felt better after and subsequently became a sun worshipper this year. I think it really makes you feel good to soak it in.
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