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Ho hum. Another study involving disease prevention and vit D

Postby Nick » Sat Feb 10, 2007 9:10 am

Another study that promotes the virtues of vitamin D. I believe these results to be consistent with studies involving MS prevention and vitamin D. (ie. Harvard's Ascherio and the nurses)

Vitamin D Backed For Cancer Prevention In Two New Studies

Science Daily — Two new vitamin D studies using a sophisticated form of analysis called meta-analysis, in which data from multiple reports is combined, have revealed new prescriptions for possibly preventing up to half of the cases of breast cancer and two-thirds of the cases of colorectal cancer in the United States. The work was conducted by a core team of cancer prevention specialists at the Moores Cancer Center at University of California, San Diego (UCSD), and colleagues from both coasts.

The breast cancer study, published online in the current issue of the Journal of Steroid Biochemistry and Molecular Biology, pooled dose-response data from two earlier studies - the Harvard Nurses Health Study and the St. George's Hospital Study - and found that individuals with the highest blood levels of 25-hydroxyvitamin D, or 25(OH)D, had the lowest risk of breast cancer.

The researchers divided the 1,760 records of individuals in the two studies into five equal groups, from the lowest blood levels of 25(OH)D (less than 13 nanograms per milliliter, or 13 ng/ml) to the highest (approximately 52 ng/ml). The data also included whether or not the individual had developed cancer.

"The data were very clear, showing that individuals in the group with the lowest blood levels had the highest rates of breast cancer, and the breast cancer rates dropped as the blood levels of 25-hydroxyvitamin D increased," said study co-author Cedric Garland, Dr.P.H. "The serum level associated with a 50 percent reduction in risk could be maintained by taking 2,000 international units of vitamin D3 daily plus, when the weather permits, spending 10 to 15 minutes a day in the sun."
The colorectal cancer study, published online February 6 in the American Journal of Preventive Medicine, is a meta-analysis of five studies that explored the association of blood levels of 25(OH)D with risk of colon cancer. All of the studies involved blood collected and tested for 25 (OH)D levels from healthy volunteer donors who were then followed for up to 25 years for development of colorectal cancer.

As with the breast cancer study, the dose-response data on a total of 1,448 individuals were put into order by serum 25(OH)D level and then divided into five equal groups, from the lowest blood levels to the highest.

"Through this meta-analysis we found that raising the serum level of 25-hydroxyvitamin D to 34 ng/ml would reduce the incidence rates of colorectal cancer by half," said co-author Edward D. Gorham, Ph.D. "We project a two-thirds reduction in incidence with serum levels of 46ng/ml, which corresponds to a daily intake of 2,000 IU of vitamin D3. This would be best achieved with a combination of diet, supplements and 10 to 15 minutes per day in the sun."

Vitamin D3 is available through diet, supplements and exposure of the skin to sunlight, or ultraviolet B (UVB). In the paper, the researchers underscored the importance of limiting sun exposure such that the skin does not change color (tan) or burn. For a typical fair-skinned Caucasian individual, adequate vitamin D could be photosynthesized safely by spending 10 to 15 minutes in the noontime sun on a clear day with 50 percent of skin area exposed to the sun. Darker skinned individuals may require more time in the sun, such as 25 minutes. For people with photosensitivity disorders, or anyone with a personal or family history of nonmelanoma skin cancer, any amount of extra sun exposure would be inadvisable.

The meta-analysis on colorectal cancer includes data from the Women's Health Initiative, which had shown in 2006 that a low dose of vitamin D did not protect against colorectal cancer within seven years of follow-up. However, the researchers wrote, the meta-analysis indicates that a higher dose may reduce its incidence.

"Meta-analysis is an important tool for revealing trends that may not be apparent in a single study," said co-author Sharif B. Mohr, M.P.H. "Pooling of independent but similar studies increases precision, and therefore the confidence level of the findings."
The authors recommend further research to study individuals for the effect of vitamin D from sunlight, diet and supplements on the risk of cancer.

Co-authors on both the breast cancer and colorectal meta-analysis papers are Edward D. Gorham, MPH, Ph.D., Cedric F. Garland, Dr.P.H.; Frank C. Garland, Ph.D.; Sharif B. Mohr, MPH; William B. Grant, Ph.D; Martin Lipkin, M.D.; Harold L. Newmark, ScD; Edward Giovannucci, M.D., ScD; and Michael F. Holick, M.D., Ph.D. Co-author on the colorectal meta-analysis paper only was Melissa Wei, B.S. Authors' institutional affiliations are UCSD Department of Family and Preventive Medicine and Moores UCSD Cancer Center (Gorham, Garland, Garland); Naval Health Research Center, San Diego (Gorham, F.C. Garland, Mohr); SUNARC-Sunlight, Nutrition and Health Research Center, San Francisco (Grant); Strang Cancer Prevention Center of Rockefeller University, New York, NY (Lipkin); Rutgers--The State University of New Jersey and Cancer Institute of New Jersey (Newmark); Harvard Schools of Public Health and Medicine (Giovannucci, Wei); and Boston University School of Medicine (Holick). Funding for this research was provided by a Congressional allocation to the Hollings Cancer Center of the Medical University of South Carolina through the Department of the Navy.
Note: This story has been adapted from a news release issued by University of California - San Diego.

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Vitamin D3 Supplement - Children

Postby dreddk » Tue Feb 27, 2007 11:43 am

I'm curious as to whether anyone is giving a Vitamin D3 supplement to their children. Given that the research indicates that there is a probibility that Vitamin D3 reduces the likelihood of developing MS I have been wondering about giving my daughters a supplement (My wife as RRMS).
If so, what product do you use?
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Postby Loobie » Tue Feb 27, 2007 12:36 pm

I have an 11 year old daughter that I give 800 IU per day of Solgar D (colicalciferol(SP?)).

I am the one with MS and I take 2400 IU of Carlson D3.

My daughter shows no ill effects from taking that quantity. I have had her on 1000 IU also since that was the only size they had at the vitamin store. Before I learned of the potential benefits of D for MS prevention, I still had her on it after I listened to a radio show talk about giving your children that much in the winter to help stave off the flu as opposed to giving them the flu shot.
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Postby dreddk » Tue Feb 27, 2007 12:57 pm

That's interesting thanks - I see in the large study of nurses that 400IU seemed to offer some benefit but then several other studies I have read suggest that around the 800IU or greater is needed to have any real effect on the body's vitamin d levels. My eldest daughter is 2 1/2 so I'm thinking I will talk to her GP about options as the supplements available in nz with a decent amount of vitamin d also have large amounts of vitamin a and are not suitable for young children.
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Postby JFH » Tue Feb 27, 2007 1:20 pm

I encourage my daugters to take at least 10ug a day.
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Postby Nick » Wed Mar 07, 2007 12:17 pm

I have three children, ages 10,8 and 2 years old. I give the older two, 2,000 IU/d and the younger one, 1,000 IU/d. I usually give the older kids two pure D3 tablets and the younger one flavoured cod liver oil or flavoured liquid D3.

DIRECT-MS, of which I am a participant, has materials which address the issue of prevention.

Protect Your Family from Multiple Sclerosis]
This booklet emphasizes the high risk for contracting MS of first-degree relatives of persons with MS. It discusses the causal factors of MS with special emphasis on vitamin D deficiency as a primary cause. Finally it demonstrates that adequate vitamin D can likely prevent MS in most cases and provides a recommended supplementation regime.

Preventing Multiple Sclerosis and is a web cast regarding nutrition and Multiple Sclerosis. The focus of the Prevention presentation is how MS can be easily, safely and inexpensively prevented by focusing on protective factors. This is a must see for those people with MS who have children.

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Postby dreddk » Wed Mar 07, 2007 1:21 pm

Hi Nick,
If you don't mind me asking, what cod liver oil are you giving your youngest? I've ordered the carlsons cod liver oil lemon flavored. The recommended dosage I have seen works out at 1 teaspoon for a 2 year old which is 400IU. Are you giving a higher dosage? I reluctant to give her more due to the high vitamin A content of cod liver oils.

Like you, once she's a bit older i'm going to switch her to the straight pills.
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Postby Nick » Wed Mar 07, 2007 2:58 pm

Hey Dredd

The CLO I give is the Arctic brand. I'm not too stringent because we don't give him cow milk nor too much gluten, thus the most likely instigators are absent or very reduced. Once he ages and is accepting of the pill form I'll try to convert him.

Of course whenever the oppotunity presents itself he gets exposed to UVR in appropriate amounts.

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Postby Nick » Fri Mar 09, 2007 9:15 am

Hi Dredd

I didn't addressyour question of how much vitamin D I give to my two yr old youngster. Ideally I would like him to have 1000 to 2000 IU/d. There's not too much credible info out there which documents how much D a toddler should have. I believe a European Commission study concluded 1000 IU/d is safe for children under two.

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Interesting Vitamin D Articles

Postby NHE » Tue Mar 27, 2007 4:06 am

I don't know if these have been discussed before, but I recently came across a couple interesting papers on vitamin D's role in MS. The first paper is available for free while I have only read the abstract for the second one.

Gene expression analysis suggests that 1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by stimulating inflammatory cell apoptosis.
Physiol Genomics. 2004 Jul 8;18(2):141-51.
    Multiple sclerosis (MS) is a debilitating autoimmune disease of the central nervous system (CNS) that develops in genetically susceptible individuals who are exposed to undefined environmental risk factors. Epidemiological, genetic, and biological evidence suggests that insufficient vitamin D may be an MS risk factor. However, little is known about how vitamin D might be protective in MS. We hypothesized that 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] might regulate gene expression patterns in a manner that would resolve inflammation. To test this hypothesis, experimental autoimmune encephalomyelitis (EAE) was induced in mice, 1,25-(OH)2D3 or a placebo was administered, and 6 h later, DNA microarray hybridization was performed with spinal cord RNA to analyze the gene expression patterns. At this time, clinical, histopathological, and biological studies showed that the two groups did not differ in EAE disease, but changes in several 1,25-(OH)2D3-responsive genes indicated that the 1,25-(OH)2D3 had reached the CNS. Compared with normal mice, placebo-treated mice with EAE showed increased expression of many immune system genes, confirming the acute inflammation. When 1,25-(OH)2D3 was administered, several genes like glial fibrillary acidic protein and eukaryotic initiation factor 2alpha kinase 4, whose expression increased or decreased with EAE, returned to homeostatic levels. Also, two genes with pro-apoptotic functions, calpain-2 and caspase-8-associated protein, increased significantly. A terminal deoxynucleotidyl transferase-mediated dUTP nicked end labeling study detected increased nuclear fragmentation in the 1,25-(OH)2D3-treated samples, confirming increased apoptosis. Together, these results suggest that sensitization of inflammatory cells to apoptotic signals may be one mechanism by which the 1,25-(OH)2D3 resolved EAE.
IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis.
J Immunol. 2006 Nov 1;177(9):6030-7.
    Multiple sclerosis (MS) results from an aberrant, neuroantigen-specific, T cell-mediated autoimmune response. Because MS prevalence and severity decrease sharply with increasing sunlight exposure, and sunlight supports vitamin D(3) synthesis, we proposed that vitamin D(3) and 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) may protect against MS. In support of this hypothesis, 1,25-(OH)(2)D(3) strongly inhibited experimental autoimmune encephalomyelitis (EAE). This inhibition required lymphocytes other than the encephalitogenic T cells. In this study, we tested the hypothesis that 1,25-(OH)(2)D(3) might inhibit EAE through the action of IL-10-producing regulatory lymphocytes. We report that vitamin D(3) and 1,25-(OH)(2)D(3) strongly inhibited myelin oligodendrocyte peptide (MOG(35-55))-induced EAE in C57BL/6 mice, but completely failed to inhibit EAE in mice with a disrupted IL-10 or IL-10R gene. Thus, a functional IL-10-IL-10R pathway was essential for 1,25-(OH)(2)D(3) to inhibit EAE. The 1,25-(OH)(2)D(3) also failed to inhibit EAE in reciprocal, mixed bone marrow chimeras constructed by transferring IL-10-deficient bone marrow into irradiated wild-type mice and vice versa. Thus, 1,25-(OH)(2)D(3) may be enhancing an anti-inflammatory loop involving hemopoietic cell-produced IL-10 acting on brain parenchymal cells and vice versa. If this interpretation is correct, and humans have a similar bidirectional IL-10-dependent loop, then an IL-10-IL-10R pathway defect could abrogate the anti-inflammatory and neuro-protective functions of sunlight and vitamin D(3). In this way, a genetic IL-10-IL-10R pathway defect could interact with an environmental risk factor, vitamin D(3) insufficiency, to increase MS risk and severity.

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Vitamin D dramatically cuts cancer risk: study

Postby beyondms » Fri Jun 08, 2007 4:49 am

More positive news for vitamin D....

Vitamin D dramatically cuts cancer risk: study News Staff

Updated: Thu. Jun. 7 2007 10:54 PM ET

A landmark new study is raising the tantalizing spectre that a simple and cheap vitamin supplement may offer a highly effective way of preventing cancer.

The research, published in the online edition of the American Journal of Clinical Nutrition, finds that a combination of vitamin D3 and calcium has a substantially marked effect on reducing cancer incidence.

The four-year study out of Creighton University in Nebraska found that women who regularly took vitamin D3 had a 60 per cent reduction in cancer infections compared to a group taking placebos.

The study followed 1,179 healthy, women 55 years and older from rural eastern Nebraska between 2000 and 2005. Participants were randomly assigned to receive 1400-1500 mg of calcium alone, or supplemental calcium plus 1,100 IU vitamin D3, or placebo.

The researchers studied only vitamin D3, which comes from animal sources and seems to be more active than vitamin D2, which is derived from plant sources.

Among the 288 women taking placebo, 20 developed breast, colon, lung or another form of cancer. Among the 445 women taking just calcium, 17 developed cancer. But among the largest group -- the 446 women taking vitamin D daily -- just 13 developed cancer.

"What we found is that a vitamin D supplement decreased the cancer incidence in postmenopausal women by about 60 per cent," lead investigator Joan Lappe, an associate professor of both medicine and nursing at Creighton University, told CTV News.

On the premise that some of the women who did develop cancer may have entered the study with undiagnosed cancers, researchers then eliminated the first-year results and looked at the last three years of the study. When they did that, the results became even more dramatic with the calcium/vitamin D3 group showing a startling 77 per cent cancer-risk reduction.

"The findings are very exciting. They confirm what a number of vitamin D proponents have suspected for some time but that, until now, have not been substantiated through clinical trial," said Lappe.

"Vitamin D is a critical tool in fighting cancer as well as many other diseases."

While the study was open to all ethnic groups, all participants were Caucasian, she noted. Lappe said further studies are needed to determine whether the results apply to different ethnic groups, to men, and to women of all ages.

This is not the first time that researchers have noted the health benefits of vitamin D. In February, two studies found that the vitamin was linked to lower rates of breast cancer and colorectal cancer. The "sunshine vitamin," as it's sometimes called, has also been shown to kill some cancer cells in laboratory experiments.

"There's a lot of evidence out there that populations in first world countries are deficient in vitamin D and if you give them more, we can prevent cancers and other diseases that have been reported to be prevented with vitamin D," said Lappe.

Humans can absorb vitamin D when ultraviolet rays from the sun trigger vitamin D synthesis in our skin. But because of our short summers in Canada and our latitude, most Canadians don't get anywhere near enough of it all year long.

That's why Dr. Reinhold Vieth, who has conducted numerous studies of vitamin D at Toronto's Mount Sinai Hospital, believes every Canadian could benefit from taking a vitamin D supplement.

"The vitamin D story is what I call a 'no-lose' proposition. Take it. You can only win," he told CTV News.

Cancer Society recommends vitamin D supplementation

Because of the growing body of evidence about vitamin D, for the first time, the Canadian Cancer Society is recommending a specific amount of supplementation for Canadians to consider taking. The Society is now recommending that:

* Adults living in Canada should consider taking vitamin D supplementation of 1,000 international units (IU) a day during the fall and winter.
* Adults at higher risk of having lower vitamin D levels should consider taking vitamin D supplementation of 1,000 IU/day all year round. This includes people who are older; with dark skin; who don't go outside often, and who wear clothing that covers most of their skin.
* At this time, the Canadian Cancer Society does not have a recommendation for vitamin D supplementation for children.

"The evidence is still growing in this area, but we want to give guidance to Canadians about this emerging area of cancer prevention based on what we know now," said Heather Logan, director of Cancer Control Policy with the Canadian Cancer Society.

"We're recommending 1,000 IUs daily because the current evidence suggests this amount will help reduce cancer risk with the least potential for harm," said Logan.

"As we find out more we will update our recommendation."

Logan cautions Canadians about relying too much on getting vitamin D through exposure to sunlight.

"It's not a good idea to rely solely on the sun to obtain vitamin D," said Logan. "For some people, it's possible that just a few minutes of unprotected sun exposure every day could increase skin cancer risk."

The Cancer Society is not changing its SunSense guidelines, as skin cancer is the most frequently diagnosed cancer in Canada.

The Society recommends that people reduce their exposure to the sun, particularly between 11 a.m. and 4 p.m. when the sun's rays are the strongest. And use a sunscreen with a sun protection factor (SPF) 15 or higher and SPF 30 if you work outdoors or if you will be outside for most of the day.

With a report from CTV medical specialist Avis Favaro and medical producer Elizabeth St. Philip
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Vit D

Postby bromley » Fri Jun 15, 2007 12:10 am

Study shines light on possible MS cause 15 June 2007

SLIP, slop, slapping to avoid skin cancer could be exposing people to increased risk of multiple sclerosis.

Researchers believe rising rates of MS could be linked to reduced levels of vitamin D, which is produced in the body by sunlight.

About 18,000 Australians are thought to have MS, where the body's killer T cells attack the protective myelin sheath around nerve fibres in the brain.

The disease usually strikes people aged in the 20s and 30s, progressively breaking down functions like mobility and eyesight or hitting in unpredictable bursts punctuated by temporary remissions.

MS Research Australia executive director Jeremy Wright said the number of MS cases was jumping by about six or seven per cent each year.

"We're seeing up to 1000 new cases every year, and that is now outpacing the rate of population growth," he said.

Mr Wright said it was unclear what was behind the rise, but there was growing evidence of a link to sunlight and vitamin D.

He said research showed the further people lived from the equator, the greater the rate of MS.

Mr Wright said Victoria's MS rate was four to five times higher than that of Queensland.

He said Victorians needed 10 to 15 minutes of sunlight exposure two to three days a week to give them adequate vitamin D levels.

"One theory is maybe we've gone a bit over the top with the slip, slop, slap campaign," Mr Wright said.

He said another favoured theory was that our increasingly hygienic environments meant our immune systems did not develop properly.

"Our children have less exposure to nasty things that might give them diseases and excite the immune system into action early in life," Mr Wright said.

"If you don't use your immune system early, it doesn't learn how to become strong against other diseases later."

Mr Wright said research promised major breakthroughs in MS.

He said new drugs that could dramatically reduce the number of attacks suffered by people with the relapse-remitting form of the disease were being tested and could be on the market within five years.

Other researchers, including at Melbourne and Monash universities, were making advances in the repair of damaged cells that made up the myelin sheath.

Source: Copyright 2007 News Limited. (15/06/07)
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Postby robbie » Fri Jun 15, 2007 4:34 am

It seems funny to read an article like this where there is a vitamin that is considered a possible cause of ms and yet people are risking their lives with drugs that could bring down a horse to stop their RRMS. If i was one of those people any talk of a goddam vitamin being the cause of such a complex disease would scare me.
Had ms for over 19 years now.
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Personal trial of Vitamin D

Postby lyndacarol » Sat Jun 16, 2007 5:02 am

Rest easy, Robbie. There was much news last year about Vitamin D; I do not get much sunshine; I thought there could be a connection, especially when I read that normal insulin seretion was dependent on Vitamin D.

So I started my own study of 1--I started taking 8000IU of Vitamin D daily since August 12, 2006. I must report no improvements in MS symptoms; I have seen other changes: I no longer get unexplainable bruising, my fingernails have lost the deep ridges I used to have.

The anecdotal evidence points to lower prevalence of MS nearer the equator, but I now believe it is due to some other mechanism--not just Vitamin D. D3 is important, but not the key. Perhaps people there are simply less confined indoors with others and catch fewer colds, flu, etc. Or diet is quite different. I believe there is another factor at play.
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Postby carolew » Sat Jun 16, 2007 6:05 am

I have had soooooo much exposure to the sun, unprotected, in the past and I STILL have MS. This theory never made sense to me. Quite the opposite, I thought I had fried my brain with so much sunbathing and tennis. :) Carole
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