jimmylegs wrote:nick that is interesting. which dietary proteins are suspect?
Med Hypotheses. 2001 Feb;56(2):163-70. Links
The multifaceted and widespread pathology of magnesium deficiency.Johnson S.
Even though Mg is by far the least abundant serum electrolyte, it is extremely important for the metabolism of Ca, K, P, Zn, Cu, Fe, Na, Pb, Cd, HCl, acetylcholine, and nitric oxide (NO), for many enzymes, for the intracellular homeostasis and for activation of thiamine and therefore, for a very wide gamut of crucial body functions. Unfortunately, Mg absorption and elimination depend on a very large number of variables, at least one of which often goes awry, leading to a Mg deficiency that can present with many signs and symptoms. Mg absorption requires plenty of Mg in the diet, Se, parathyroid hormone (PTH) and vitamins B6 and D. Furthermore, it is hindered by excess fat. On the other hand, Mg levels are decreased by excess ethanol, salt, phosphoric acid (sodas) and coffee intake, by profuse sweating, by intense, prolonged stress, by excessive menstruation and vaginal flux, by diuretics and other drugs and by certain parasites (pinworms). The very small probability that all the variables affecting Mg levels will behave favorably, results in a high probability of a gradually intensifying Mg deficiency. It is highly regrettable that the deficiency of such an inexpensive, low-toxicity nutrient result in diseases that cause incalculable suffering and expense throughout the world. The range of pathologies associated with Mg deficiency is staggering: hypertension (cardiovascular disease, kidney and liver damage, etc.), peroxynitrite damage (migraine, multiple sclerosis, glaucoma, Alzheimer's disease, etc.), recurrent bacterial infection due to low levels of nitric oxide in the cavities (sinuses, vagina, middle ear, lungs, throat, etc.), fungal infections due to a depressed immune system, thiamine deactivation (low gastric acid, behavioral disorders, etc.), premenstrual syndrome, Ca deficiency (osteoporosis, hypertension, mood swings, etc.), tooth cavities, hearing loss, diabetes type II, cramps, muscle weakness, impotence (lack of NO), aggression (lack of NO), fibromas, K deficiency (arrhythmia, hypertension, some forms of cancer), Fe accumulation, etc. Finally, because there are so many variables involved in the Mg metabolism, evaluating the effect of Mg in many diseases has frustrated many researchers who have simply tried supplementation with Mg, without undertaking the task of ensuring its absorption and preventing excessive elimination, rendering the study of Mg deficiency much more difficult than for most other nutrients.
jimmylegs wrote:thanks for all that nick. so are you saying that some people need more vitamin d supplementation than others in order to help their immune system put the brakes on the self-tissue issues?
jimmylegs wrote:hi nick, when i first asked for a D3 test i had been supplementing for a few months, and for the last few weeks it had been at 4000 per day. so i never knew my real baseline number, but at that point i got tested and i was only at 72!
after that, i went for 150 nmol/L by taking 50,000 per day for ten days, divided into two 25,000 doses (i couldn't make it any smaller at that concentration, or i would have done 10,000 at a time). i got to 149 which was great. last year i stopped supplementing because i was working outside in australian late spring, and then i went a while without supplements even when i got back to canadian winter, so that i could get a clean baseline test, but i waited too long and my level was down to 80.
i'm back on 4000 a day because i'm not really getting out in the sun so far this summer, only a few hours so far. and i'm not perfect about taking my supps every day. but i need to have another test to see if i'm at least back up to 100 at a minimum.
i have this cal mag d3 pill that has 1000 units in it, plus an additional 3000 in little d3 pills. should i just be taking four of the big cal mag d3s you think, to get the right balance?
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