all things vitamin D

Discuss herbal therapies, vitamins and minerals, bee stings, etc. here

Postby CVfactor » Wed Feb 09, 2011 6:37 pm

All,

Here is further evidence that local metabolizm of 1,25-dihydroxyvitamin D
(active form of vitamin D) at the cellular level is different than what is found in your blood serum:

http://www.ncbi.nlm.nih.gov/pubmed/20211254

From my point of view, I am taking as much Vitamin D3 (cholecalciferol) to the estimated lowest observed adverse effect level (LOAEL) while monitoring my calcium level to be sure that I do not become hypercalcemic.

What I am taking is 40,000IU/day. The LOAEL is described in this paper:

http://www.ajcn.org/content/69/5/842.full

So, I have been on this dosage for over four months and feel beter than I have ever felt since I became sick (no relapses).

The study below also brought subjects to this high of a dose without becoming hypercalcemic:

http://www.ncbi.nlm.nih.gov/pubmed/20427749

So, your doctor will tell you that taking this much Vitamin D will cause you to become hypercalcemic, but I don't believe it.

I think that the future study of clinical trials will probably be done with Vitamin D analogs, because these can be patented and proclaim the benefits of not causing hypercalcemia:

http://www.jimmunol.org/content/186/1/132.abstract
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Postby SCGirl » Mon Feb 14, 2011 11:21 am

Well, I must be the most unlucky person in the world (really!). I grew up in sunny SC and still live here. I was always a sun worshipper and thought if anything, I was risking a chance at skin cancer. I had to have Vitamin D levels out the roof or at least I would think. But I am sure this is one of the many probable reasons for MS.
If they can put a man on the moon, why can't they determine the cause of this miserable disease and FIX IT?! Sorry, needed to vent...
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Postby CVfactor » Mon Feb 14, 2011 6:43 pm

Our friends at Eli Lilly and Company seem to be investigating the uses of Vitamin D and it's analogs:

http://edrv.endojournals.org/cgi/content/full/26/5/662
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Postby WantingToKnow » Tue Feb 15, 2011 2:07 pm

Same here! I grew up in SC and still live here. If you already have MS, does sunlight help, or does it not matter I wonder? :)
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Postby SCGirl » Tue Feb 15, 2011 2:37 pm

I believe studies show that you still need more than the average amount of Vitatmin D and since summer is just around the coner, that gives me an excuse to worship the sun! 8)
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Postby itaska21 » Wed Feb 16, 2011 6:15 pm

The sun and humidity make my symptoms worse! I've spoke to others who experience flare-ups in the sun too. This study definitely has me scratching my head. :?:
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Postby CVfactor » Wed Feb 16, 2011 6:29 pm

For those who think MS is autoimune, here are more papers on regulatory T-cells:

http://www.springerlink.com/content/v5x43485w65ll710/

http://www.ncbi.nlm.nih.gov/pubmed/19350586

I believe a cure is close with Treg cell therapy, but I have found the natural method to this route with Vitamin D.

I wish the best to you all and I hope you find a solution that works for you.
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Postby 1hunter » Fri Feb 18, 2011 9:40 am

are there suppliments we should NOT take at the same time that dont mix well?
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Postby jimmylegs » Fri Feb 18, 2011 3:46 pm

not take at the same time as d3, do you mean? well i know if you take magnesium that you definitely must take some of your daily dose *with* the d3, and the rest of it at a separate time. d3 makes use of magnesium as it gets processed. but your body needs mag for other things not just d3 handling. i learned this the hard way and it was a pharmacist that got me back on track.
READ ME key info on nutrient targets - www.thisisms.com/ftopict-2489.html
my approach: no meds so far - just nutrient-dense anti-inflammatory whole foods, and supplements where needed
info: www.whfoods.com, www.nutritiondata.com
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Postby 1hunter » Fri Feb 18, 2011 4:26 pm

Thanks Jimmy
that is good to know, are there others that should or shouldn't be mixed? I thought i read we should take fish oil with vit. D But not calcium with with fish oil.
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Postby CVfactor » Fri Feb 18, 2011 5:47 pm

The review article below is probably the best that I have found that explains the regulatory T-cell function in a easy to understand way:

http://www.nature.com/nrneurol/journal/v4/n7/full/ncpneuro0832.html
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Postby jimmylegs » Fri Feb 18, 2011 7:33 pm

hey there no probs. i had not heard pros or cons about fish oil timing/combinations, but i do know that magnesium and calcium compete with each other for absorption so that's a combo to avoid in the same pill OR make sure the ratio of ca to mag is right for you, depending on your problem eg spasticity vs weakness or whatever.
READ ME key info on nutrient targets - www.thisisms.com/ftopict-2489.html
my approach: no meds so far - just nutrient-dense anti-inflammatory whole foods, and supplements where needed
info: www.whfoods.com, www.nutritiondata.com
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Postby CVfactor » Wed Feb 23, 2011 5:52 pm

Here is another article on Treg cell dysfunction using monkeys as opposed to mice as test subjects:

http://www.ncbi.nlm.nih.gov/pubmed/19539557
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Postby CVfactor » Sun Feb 27, 2011 5:46 pm

Here is a paper that describes the concept of molecular mimicry:

http://www.ncbi.nlm.nih.gov/pubmed/19303388

For those that are not familiar, it is in essence the fact that certain pathogen peptides have a remarkably similar structure to that of myelin basic protein.

This is one explanation of why people with MS that have a dysfunctional immune system (in particular Tregs) have a propensity to attack the myelin sheath on their neural axons.
Last edited by CVfactor on Thu Apr 28, 2011 5:50 pm, edited 2 times in total.
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Postby CVfactor » Mon Feb 28, 2011 7:04 pm

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