Uric Acid With Multiple Sclerosis And Other Neurological Diseases
Uric Acid Research From Mult Scler. 2007 Oct 17; [Epub ahead of print]
Serum uric acid levels of patients with multiple sclerosis and other neurological diseases.
Peng F, Zhang B, Zhong X, Li J, Xu G, Hu X, Qiu W, Pei Z.
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, People’s Republic of China.
The serum uric acid (UA) levels were measured in 112 patients with multiple sclerosis (MS) and 794 patients with different types of other neurological diseases (OND) or healthy control group. Serum UA levels, along with relevant clinical parameters of MS and OND, were also investigated.
MS patients had significantly lower UA levels than those with
Transient ischemia attack (344.6+/-130.6 micromol/L, P=0.000)
Cerebral hemorrhage (311.9+/-104.7 micromol/L, P=0.000)
Cerebral infarction (291.3+/-101.6 micromol/L, P=0.014)
Healthy control group (312.1+/-92.8 micromol/L, P=0.000)
MS patients had significantly higher serum UA levels than those with:
Cryptococcus meningitis or meningoencephalitis (178.9+/-107.0 micromol/L, P=0.000)
Tuberculous meningitis or meningoencephalitis patients (175.7+/-99.9 micromol/L, P=0.000)
There were no significant differences in UA levels between patients with MS and those with:
Viral meningitis or encephalitis
Polymyositis or dermatomyositis
In addition, uric acid levels were independently correlated with gender and duration of MS, but neither with MRI activity, disability nor subtypes of the disease in MS patients.
Our data suggest that UA has two biphasic functions: neuroprotective and injurious. Our studies may help physicians to deal with conditions having abnormal UA levels.
Multiple Sclerosis 2007; 00: 00-00. http://msj.sagepub.com
PMID: 17942520 [PubMed - as supplied by publisher]