jimmylegs wrote:but failed to alter the production of the anti-inflammatory cytokine IL-10
UA acts upon astroglia and upregulates protein levels of EAAT-1, a glutamate transporter, to protect spinal cord neurons from glutamate induced toxicity.
There is an abundance of evidence that suggests that low UA levels are associated with the development and progression of a variety of diseases. A number of studies have found an independent negative correlation between serum UA levels and MS (Spitsin et
al., 2001b; Toncev et al., 2002; Rentzos et al., 2006).
(P 20) Furthermore, a recent clinical study found that the administration of inosine, a UA precursor, stopped the progression of MS in all 11 patients that received the drug and improved some of the symptoms of the disease in 3 of the patients (Spitsin et al., 2001a).
(P 21) because both decreased as well as elevated UA levels may contribute to the development and progression of a number of disease states, significant alterations in UA levels that result in above or below normal serum UA concentrations should be minimized.
(P 6) the normal range of UA concentration falls somewhere between 120 µmol/L and 380 µmol/L, varying slightly depending on gender.
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