Zinc in Multiple Sclerosis: A Systematic Review and Meta-Analysis (2016)http://asn.sagepub.com/content/8/3/1759 ... 1.abstract
"In the last 35 years, zinc (Zn) has been examined for its potential role in the disease multiple sclerosis (MS). This review gives an overview of the possible role of Zn in the pathogenesis of MS as well as a meta-analysis of studies having measured Zn in serum or plasma in patients with MS. Searching the databases PubMed and EMBASE as well as going through reference lists in included articles 24 studies were found measuring Zn in patients with MS. Of these, 13 met inclusion criteria and were included in the meta-analysis. The result of the meta-analysis shows a reduction in serum or plasma Zn levels in patients with MS
with a 95% CI of [−3.66, −0.93] and a p value of .001 for the difference in Zn concentration in μM. One of six studies measuring cerebrospinal fluid, Zn levels found a significant increase in patients with MS with controls. The studies measuring whole blood and erythrocyte Zn levels found up to several times higher levels of Zn in patients with MS compared with healthy controls
with decreasing levels during attacks in relapsing-remitting MS patients. Future studies measuring serum or plasma Zn are encouraged to analyze their data through homogenous MS patient subgroups on especially age, sex, and disease subtype since the difference in serum or plasma Zn in these subgroups have been found to be significantly different. It is hypothesized that local alterations of Zn may be actively involved in the pathogenesis of MS."
yep, maybe. hey what was that major nutritional differential dx for ms again? oh yeah vit b12:
The zinc content of
whole blood, plasma, leukocytes and erythrocytes
in the anemias (1949)http://europepmc.org/abstract/med/18129102
"In pernicious anemia [JL: ie b12 deficiency], unit values for erythrocytes were significantly elevated above normal.
Under successful liver therapy there was a progressive fall in unit value which reached normal when the red blood cell count had risen to normal"
this suggests to me that yes ms patients have low serum zinc, and if you're worried about high erythrocyte zinc, have a look at b12 status too.
going back to the successful treatment mentioned above. i had to look up this 'liver therapy'. yup, injectable liver. oh hello, dr. klennerhttp://www.townsendletter.com/Klenner/klenner4.htm
not that i ever took such stuff myself. but i did correct my lab-documented serum zinc and b12 deficiencies, among other things. not that my personal b12 issues were the pernicious sort.
just stupidly self-inflicted via excessively plant-based diet. i'm going to enjoy the venison-spinach-feta burgers on the menu for din-dins tomorrow nite