omg srsly LMAO
Inhalational Alzheimer's disease: an unrecognized—and treatable—epidemichttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789584/
"Laboratory studies often, but not always, feature hypozincemia and/or a high copper:zinc ratio
, and may also suggest adrenal fatigue with reduced pregnenolone, DHEA-S (dehydroepiandrosterone sulfate), and/or AM cortisol."
yea some references would be great so that we can see if we agree with your classification of 'not hypozincemia'
"Laboratory evaluation of CIRS reveals increases in C4a (complement component 4a), TGF- β1 (transforming growth factor beta-1), MMP9 (matrix metalloprotease 9), specific cytokines, and decreases in MSH (melanocyte-stimulating hormone), VEGF (vascular endothelial growth factor), and ADH (anti-diuretic hormone), as well as frequent hypercortisolemia, hypozincemia
, and other abnormalities... Here I report that type 3 Alzheimer's disease is a phenotypic manifestation of CIRS. Both may present with cognitive decline that goes beyond a restricted amnestic presentation to include executive dysfunction and other deficits; as well as depression, hypozincemia
, hypersensitivity to stress, and dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis."
just so we're all on the same page here, note:
serum copper to zinc ratio (optimal 0.70–1.00) per http://link.springer.com/article/10.100 ... 016-0720-5
(aside: i often flip it and think of serum zn:cu
~1.1 as a good target)
This is a follow-up description of the first patient described in a previous report . A 52-year-old woman presented with a two-year history of cognitive decline... serum copper 101mcg/dl, serum zinc 56mcg/dl, and Cu:Zn ratio 1.8."
and, done. at least double serum zinc to get that cu:zn ratio under 1.0, 101/112 = 0.9, NEXT!
This is a follow-up description of the second patient described in a previous report . A 59-year-old man began to note word-finding difficulties, followed by difficulties with arithmetic... serum copper 97mcg/dl, serum zinc 59mcg/dl, Cu:Zn ratio 1.6"
k got it, double zinc and push copper to 110 to achieve optimal cu:zn ratio, 110/118 = 0.93, NEXT!
Patient 3, no zinc data? tsk tsk tsk.
A 54-year-old man developed depression after 70% of his company's employees were laid off. He was treated with an antidepressant, and three years later began to have difficulty understanding the difference between left-turn lanes, failing to appreciate the difference between the more acute left turn (far left lane) and the more gentle left turn (second lane from the left), leading to lane crosses and near accidents. He then developed executive, visuospatial, and memory deficits ... zinc 78mcg/dl, copper 73mcg/dl"
calculate the cu:zn ratio
this can be the example of when ratios may not be considered in isolation. i can relate to this guy's driving and visuospatial challenges. why yes, that *would* be from when i was zinc deficient
this case probably looks like 'not hypozincemia' with that fancy 78 mcg/dl lol. pretty much circling the drain however.
now let's get out of the bottom end of the magical 'normal' range, put copper to 110, zinc to 120, and call us in the morning.
A 50-year-old woman experienced depression following a hysterectomy, despite hormone-replacement therapy (although resulting hormone levels were not determined, so it is unknown whether optimal levels were achieved). Four years later she began to have word-finding difficulty, disorientation, difficulty driving, difficulty following recipes and other instructions, and increased depression following her son's leaving home... zinc 82mcg/l, copper 99mcg/l, copper:zinc ratio 1.2"
erm, we mean mcg/dl
assuming yes, once again let's push that zinc up closer to 120mcg/dl, copper up to 110mcg/dl, and see where you are
(hint: cu:zn ratio will be 0.92, zn:cu ratio will be 1.1)
A 54-year-old woman began to have difficulty driving at night, followed by difficulty writing numbers, along with exhaustion. This was initially ascribed to menopause. [
] She was unable to complete her work in a timely fashion, and had to check her work many times over because of a propensity to make mistakes, all of which was highly unusual for her..."
helloooo bloods pls?
A 64-year-old man began to complain of headache, leg cramps, irritability, distractibility, and difficulty with memory. Evaluation noted in addition a peripheral neuropathy and hyposmia. Neuro-psychological assessment revealed a high-functioning individual with mild reductions in spatial > verbal memory... serum copper 97mcg/dl, serum zinc 57mcg/dl, copper:zinc ratio 1.7."
1.7?!! no, no, NO! double the zinc, gives you 0.85 serum cu:zn ratio, :yawn:
OK so now you'll interpret your data, whaddaya got..
"These findings suggest that patients with presentations compatible with type 3 Alzheimer's disease should be evaluated for CIRS (as well as other toxic exposures, such as mercury and copper)." OMG KMN
no hits for zinc in the ENTIRE discussion. just sayin, this study never gets published in jimmylegs' alternate universe.
sweet jeebus i'm within a decade of the age of some of these ppl. glad i figured this stuff out long before having a chance of getting chucked into the mainstream alzheimer's management machine wow.