"High dose thiamine improves fatigue in multiple sclerosis"

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"High dose thiamine improves fatigue in multiple sclerosis"

Postby brm » Sat Aug 03, 2013 7:08 am

Hi all,

In case it hasn't been posted here somewhere: http://www.ncbi.nlm.nih.gov/pubmed/23861280 , "High dose thiamine improves fatigue in multiple sclerosis".

I can only read the abstract so it's a little vague on the definition of "high dose", but there's a similar article (http://www.ncbi.nlm.nih.gov/pubmed/23379830) from the same authors but for IBD and there the dose is 600mg for a patient of 60kg, and 1500mg for 90kg.

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Re: "High dose thiamine improves fatigue in multiple scleros

Postby CureOrBust » Sat Aug 03, 2013 5:50 pm

Just something I recently read.
From the Wiki: https://en.wikipedia.org/wiki/Sulbutiamine
Sulbutiamine (brand name: Arcalion) is a synthetic derivative of thiamine (vitamin B1). As a dimer of two modified thiamine molecules, it is a lipophilic compound that crosses the blood–brain barrier more readily than thiamine and increases the levels of thiamine and thiamine phosphate esters in the brain.

http://smartdrugsmarts.com/dr-stephen-b ... butiamine/
How Japanese Sailors Discovered the Need for a Synthetic Vitamin B1

During WW1, Japanese sailors began to experience symptoms like loss of mental sharpness and fatigue. These turned out to be symptoms of a disease called Beriberi, caused by a deficiency of Vitamin B1 (Thiamine).

To combat these effects, the Japanese sought to develop a version of Vitamin B1 that lasted longer and reached the brain more easily. Because the blood-brain barrier – the thin safety membrane encasing your noggin – is highly polar, molecules that are non-polar can slip through quite easily. Decreasing the polarity of compounds to help them reach the brain has been a tactic known to scientists for a long time. The application of this tactic to Thiamine was to oxidize the substance without any other compounds present, creating a non-polar “dimer” of two bonded-together Thiamine molecules. In this form (Sulbutiamine), the once-polar Thiamine skips much more easily into the brain.

I by chance have purchased a 98.21% pure powder for about 50 doses (25g), for another reason (long story). I bought it from eBay. It tastes pretty bad, so needs to be in caps, which I can do. My fatigue is not as debilitating as some, and I have Modafinil for when it is bad, so I am a poor test bunny. Its a pity the researchers didn't try/compare it.
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Re: "High dose thiamine improves fatigue in multiple scleros

Postby THX1138 » Sat Aug 03, 2013 8:34 pm

In the book, The Magnesium Miracle I read that Thiamin is needed for cells to absorb magnesium.
Insufficient Magnesium causes fatigue so I wonder if it may be the the affect of the Thiamin on the Magnesium causing reduced fatigue also??

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