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minocycline and interferon-beta in a model of MS

http://www.ncbi.nlm.nih.gov/entrez/quer ... query_hl=1

J Neuroimmunol. 2005 Aug;165(1-2):83-91. Related Articles, Links


Effective combination of minocycline and interferon-beta in a model of
multiple sclerosis.

Giuliani F, Fu SA, Metz LM, Yong VW.

Department of Clinical Neurosciences, University of Calgary, Calgary,
Alberta, Canada.

The objective of the current study was to investigate whether minocycline
improves the effect of an existing multiple sclerosis (MS) medication,
interferon-beta, on experimental autoimmune encephalomyelitis (EAE) in mice. ...
Read more : minocycline and interferon-beta in a model of MS | Views : 1486 | Replies : 0


Bursting the elementary bodies

David has done a lot of work to his web site, which is worth a look http://www.davidwheldon.co.uk/ms-treatment.html
This page is especially worth a look:

Easing mitochondrial stress in chronic Chlamydia pneumoniae infections: the use of dietary supplements

http://www.davidwheldon.co.uk/supplement_rationale.html

and especially this:

http://www.davidwheldon.co.uk/NAC.html

Bursting the elementary bodies


The protein coat which surrounds and protects the chlamydial elementary body relies on disulphide bonds within and between macromolecules to maintain its conformity. Reduction of these bonds disrupts the ...
Read more : Bursting the elementary bodies | Views : 1642 | Replies : 1


ABX, W/ Rebif

Does anyone have any one have any casual recommendations as to what ABX to take, how much to take, and the frequency? I noticed that the trials running now only involve mino, or doxy, but I noticed several of you all posting that you are taking both? or other combo's? Why, what is the mode of action? As long as you are receiving the MMP's, isn't that what matters? Paratek is developing a non-antibiotic tetracycline, ...
Read more : ABX, W/ Rebif | Views : 1519 | Replies : 3


My lazy update for anyone whos interested

Ok,

I have now been on doxy and roxi since about the 10th Sep this year.

I cannot honestly say I have had any reactions to the two antibiotics, so I decided to start the flagyl a little early (ie after only 3-4 weeks). Ok, so im impatient. It gets worse...

I also thought, lets try for the 5 day flagyl (metronidazole) pulse, and monitor my body temp and how i felt VERY closely.

So, ...
Read more : My lazy update for anyone whos interested | Views : 9726 | Replies : 54


Interesting talk on link of histamine and a "viral"

Hi,

I found this bit at http://weeksmd.com/articles/ms/JVW_Multiple_Sclerosis.html while looking into procarin.

Its interesting, but it seems like something that would be easy to prove (or disprove).

Elaine DeLack has a different point of view. Based on her research (she cites the Journal of Neuroscience Research; Archives of Neurology; Pharmacology, - Biochemistry and Behavior, Journal of Laboratory and Clinical Medicine; Annals of Neurology; Journal of Neurochemistry) she writes: "I believe that MS is a result of ...
Read more : Interesting talk on link of histamine and a "viral" | Views : 2081 | Replies : 1


feeling spongy pain after abx

HI.

I have been taking Minocycline 50 mg every other day for 3 weeks. I am slowly increasing it as I go. Anyways, for the last week or so I have had something like bone pain in my arm and then again in my right leg.

It was a good thing I was sitting down because when this spongy bone pain struck my right arm, I would have fallen. It was quick though. The leg ...
Read more : feeling spongy pain after abx | Views : 2068 | Replies : 3


Combined Avonex and Doxycycline treatment from AC/ECTRIMS

http://www.docguide.com/news/content.nsf/news/8525697700573E188525709000690E6B

Doxycycline Could Enhance Interferon Beta 1-a (Avonex) Therapy in Remitting Relapsing MS: Presented at ECTRIMS
By Bruce Sylvester

THESSALONIKI, GREECE -- October 4, 2005 -- Interim findings from an ongoing study suggest that the addition of oral doxycycline to interferon beta 1-a (Avonex) therapy for patients with relapsing remitting multiple sclerosis (RRMS) results in statistically significant reduction of gadolinium enhancing (Gd+) lesions compared to interferon beta 1-a monotherapy..........................


................................"We saw a great reduction in ...
Read more : Combined Avonex and Doxycycline treatment from AC/ECTRIMS | Views : 2207 | Replies : 7


A proper Introduction

I've started on doxcycline after contacting David Wheldon. :D

1998 i was admitted to hospital with retrobulbar neuritis and spastic weakness.I was told they thought I had MS, however MRI scans were normal.I was discharged from first Neuro going from MS to ME.

I got a second opinion with an MS Specialist who said he thought it was MS but rare not to show lesions.I do ...
Read more : A proper Introduction | Views : 1745 | Replies : 1


Melatonin info. for Marie

Melatonin

Sleep disorders are common in MS, with a flattening of the normal circadian sleeping/waking rhythm, leading to wakefulness at night and somnolence during the day One cause of this may be decreased nocturnal biosynthesis of melatonin [Wu YH et al., Molecular changes underlying reduced pineal melatonin levels in Alzheimer disease: alterations in preclinical and clinical stages. J Clin Endocrinol Metab. ...
Read more : Melatonin info. for Marie | Views : 6010 | Replies : 3


Easing mitochondrial stress in chronic CPn infections

Apart from slowly working his way through some rewriting to his first page:

http://www.davidwheldon.co.uk/ms-treatment.html

David has made a new page:

http://www.davidwheldon.co.uk/supplement_rationale.html

Easing mitochondrial stress in chronic Chlamydia pneumoniae infections: the use of dietary supplements

In health a balanced diet provides all the vitamins and antioxidants necessary to maintain vigour, and supplementation cannot reasonably be recommended.

In disease states, however, the situation is different. Chronic persistent infections with Chlamydia pneumoniae are characterized by high levels of ...
Read more : Easing mitochondrial stress in chronic CPn infections | Views : 1554 | Replies : 1


 

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