This Is MS Multiple Sclerosis Community: Knowledge & Support

I am trying to get Campath off-label. The thing that worries me, even though I am still RRMS, I have had symptoms for over 13 years, with a diagnosis about 3 years ago.

Most of the people I have seen here who have received it, have been usually considerably less time with this disease, but more aggresive. I have read the studies that show its more effective with people in early RRMS, and I don't ...

Below youtube videos from Dr Alasdair Coles(leader of the research on Campath) exlains risks and gains from Campath.

ttp://www.youtube.com/watch?v=6QvOiDfvrqg
http://www.youtube.com/watch?v=HaYbTvSO0SY
http://www.youtube.com/watch?v=SZuRvfFE8pI
http://www.youtube.com/watch?v=ZO4VNIQKCok
http://www.youtube.com/watch?v=yCPLhby3Gk8

Our neuro is one of the coordinators of the phase III trials for Campath.Other than having a good CV,he is very open-minded and quite straightforward so we highly value his opinion..Regarding the side effects,his opinion is that although they are potentially very serious (ie strokes can occur because of the bleeding disorder),they are in most cases manageable if the patient is closely monitored and the risk identified.

I just read the phase II trial paper ...

VIDEO

And another VIDEO

Hello, thank you all for replying.
K6isten, you have a great story as well. I will be doing a full Allergy test in about one month and will let you know the results. Right now I am so inflamed that everything would come back positive. In addition, I too have suffered from several bacterial and viral infections after receiving Campath. I am still trying to get over one right now. The allergies along with infections ...

I just completed my visit for my 3 month check up. Blood counts continue to increase and hopefuly will be back to pre-campath levels in a few more months. My energy level is increasing and I am having fewer days each week where I just want to get home to relax/sleep. I hope all of the other campather's out there are doing well.

Hello, I received Campath off lable in April of this year. It is very true that the reasurch trials have shown promising results for RRMS. Some studies have shown Campath to be 84% more effective than Rebif, but like any drug you need to seriously consider the drug in your perticular case carefuly and READ, READ, READ forums like these that have patients discribing their specific reactions.

Prior to Campath, I had tried Copaxone, Betaserone, ...

improvements on disability scale in campath group, reduced lesions, better brain volume, no diff. between 12 or 24 mg doses....looks alot better than interferon-


Results Alemtuzumab significantly reduced the rate of sustained accumulation of disability, as compared with interferon beta-1a (9.0% vs. 26.2%; hazard ratio, 0.29; 95% confidence interval , 0.16 to 0.54; P<0.001) and the annualized rate of relapse (0.10 vs. 0.36; hazard ratio, 0.26; 95% CI, 0.16 to 0.41; P<0.001). The mean disability ...

I know most has been cover over and over, but I found the following, and it seems to cover most points regarding Campath's method of action, in a clear and concise mannor. Its not for MS specifically, but its the same compound being used.

Alemtuzumab
Pharmacology and use:
Campath is used to treat leukemia by exploiting antibody mediated lysis of CD52 presenting cells. The CD52 antigen is a cell surface protein found on essentially all ...

The Accelerated Cure Project has produced a note on last week's ECTRIMS / ACTRIMS / LACTRIMS MS research conference. Here is the section from the note on Campath (Alemtuzamab).

Satellite Symposium -- Researching the Potential for a New
Treatment Paradigm: Alemtuzumab in MS (Sponsored by Bayer HealthCare and Genzyme) *** (Hollie)

At last year's ECTRIMS, there was a lot of exciting data about
alemtuzumab (Campath). Phase 3 studies are now underway so this was
more ...