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A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Five-Year Longitudinal Study of Neck Vessel Area

Five-Year Longitudinal Study of Neck Vessel Cross-Sectional Area in Multiple Sclerosis

http://www.ajnr.org/content/early/2018/07/26/ajnr.A5738

BACKGROUND AND PURPOSE: Alterations of neck vessel cross-sectional area in multiple sclerosis have been reported. Our aim was to investigate the evolution of the neck vessel cross-sectional area in patients with MS and healthy controls during 5 years.

CONCLUSIONS: For 5 years, patients with MS showed significant cross-sectional area decrease of all major neck vessels, regardless of ...
Read more : Five-Year Longitudinal Study of Neck Vessel Area | Views : 304 | Replies : 0


Zamboni: Review of the Brave Dreams trial

Extracranial Veins in Multiple Sclerosis: Is There a Role for Vascular Surgery?

https://www.ejves.com/article/S1078-5884(18)30387-3/fulltext

Conclusions and Perspectives

From a pathophysiological point of view the post hoc analysis reported above suggests a role of impaired extracranial venous flow in lesion development in patients with MS, as well as the probability of significant advantages when the brain outflow is restored. This finding continues to support the CCSVI hypothesis and the contribution of the jugular flow to cerebral ...
Read more : Zamboni: Review of the Brave Dreams trial | Views : 267 | Replies : 0


Cardiovascular conditions are as common in those with MS

Cardiovascular conditions are as common in those with demyelinating diseases (multiple sclerosis, neuromyelitis optica and transverse myelitis)

https://www.researchgate.net/profile/Pa ... elitis.pdf

Background: Cardiovascular conditions are associated with poorer outcomes in multiple sclerosis (MS). Whether
the burden of cardiovascular conditions differs between those with demyelinating disease and unaffected controls
is not clear. The objective of this study is to investigate the burden and age of onset of cardiovascular
conditions in a ...
Read more : Cardiovascular conditions are as common in those with MS | Views : 290 | Replies : 0


recent zamboni interview (may 2018)

It is in italian. Can somebody translate?

https://www.youtube.com/watch?v=jgKZun8umEw
Read more : recent zamboni interview (may 2018) | Views : 313 | Replies : 2


MS B-cells in vitro do weird things. CCSVI link?

This is an article that I am reading slowly, as I do not understand most of the things it says. But the summary is that MS B-cells do weird things. Something that was already suspected, because B-cells depletion with anti-CD20 MABs is the best thing we have at this time against MS.

It seems that the researchers have extracted B-cells from MS patients and infected them with the Epstein-Barr virus EBV. After that, it seems ...
Read more : MS B-cells in vitro do weird things. CCSVI link? | Views : 569 | Replies : 0


Cerebral Blood Flow Changes in Multiple Sclerosis

Cerebral Blood Flow Changes in Multiple Sclerosis and Neuromyelitis Optica and Their Correlations With Clinical Disability.

https://www.ncbi.nlm.nih.gov/pubmed/29780351

Abstract

Distinguishing relapsing-remitting multiple sclerosis (RRMS) and neuromyelitis optica (NMO) is clinically important because they differ in prognosis and treatment. This study aimed to identify perfusion abnormalities in RRMS and NMO and their correlations with gray matter volume (GMV) atrophy and clinical parameters. Structural and arterial spin labeling MRI scans were performed ...
Read more : Cerebral Blood Flow Changes in Multiple Sclerosis | Views : 540 | Replies : 0


red blood cells have altered metabolism

red blood cells have altered metabolism

https://search.proquest.com/openview/25 ... 750&diss=y

Glucose transporter 1 (GLUT1) is the main glucose transporter on RBCs, and all metabolism within theRBC involves glucose.RBC GLUT1 content was used as a measure of RBC metabolism, andelevated RBC GLUT1 content is proposed to be associated
with increased cell metabolism.RBCs obtained from MS patients contained 23.3± 4.8% more GLUT1 than control RBCs, while T1D RBCs
contained 23.6± 4.2% less ...
Read more : red blood cells have altered metabolism | Views : 531 | Replies : 0


new biomarker linked to blood flow

Quote: "The glycocalyx (GLX) is carbohydrate-rich outer surface of the blood vessel wall and is the first interaction between the blood and the vessel. We hypothesized that cleavage of the GLX may be an early stage predictor of immune attack, blood-brain barrier (BBB) breakdown, and disease severity in MS".

Detection of glycan shedding in the blood: New class of multiple sclerosis biomarkers?

https://www.frontiersin.org/articles/10 ... 4/abstract

Introduction: Multiple Sclerosis ...
Read more : new biomarker linked to blood flow | Views : 567 | Replies : 0


impaired cerebral perfusion in MS

Long paper about general brain perfusion, but deals with MS at the end:

http://journals.sagepub.com/doi/pdf/10. ... 1918774800

Extracted from the article:

Brain perfusion in MS

In patients with MS, cerebral hypoperfusion was first observed about 30 years ago and it has become evident now that reduced cerebral perfusion, likely due to NVU malfunction and involving both the gray and white matter, is an integral feature of MS pathology. These findings ...
Read more : impaired cerebral perfusion in MS | Views : 497 | Replies : 0


CCSVI angioplasty procedure ok to do unless called research

https://www.medpagetoday.com/special-re ... race/72033

The FDA could intervene in the cases of Arata and McGuckin because they were calling their procedures research, over which the agency has jurisdiction. However, the procedure can be done without federal scrutiny if there is no research involved. It is viewed as akin to the "off-label" use of a drug, in that the stent devices were approved for use in arteries, not veins.


Just one ...
Read more : CCSVI angioplasty procedure ok to do unless called research | Views : 542 | Replies : 0


 

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