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A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Homocysteine decreases cerebral perfusion

I think that any discussion of endothelial health and cerebral perfusion is incomplete without considering homocysteine.

Resting brain perfusion and selected vascular risk factors in healthy elderly subjects.
PLoS One. 2014 May 19;9(5):e97363.

    BACKGROUND AND PURPOSE: Both cerebral hypoperfusion and vascular risk factors have been implicated in early aging of the brain and the development of neurodegenerative disease. However, the current knowledge of the importance of cardiovascular health on resting brain perfusion is limited. The ...
Read more : Homocysteine decreases cerebral perfusion | Views : 397 | Replies : 3

Alzheimer Nitric Oxide NOS2

Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease–like pathologies. This model demonstrates an altered immune redox state reminiscent of the human disease and capitalizes on data indicating critical differences between human and mouse immune responses, particularly in nitric ...
Read more : Alzheimer Nitric Oxide NOS2 | Views : 318 | Replies : 1

Thoracic Outlet Syndrome/CCSVI?

Hi everyone,

I was diagnosed last week with Thoracic Outlet Syndrome; however, my doctor tells me that all my other symptoms cannot be caused by TOS. These include leg numbness, tingling, twitching legs, abdomen, and feet (very small...only I notice). Also, in a vascular test, it was noticed that my feet were completely "flat" as far as getting blood to them...there is NO blood getting to my toes! I even get these lesions on my ...
Read more : Thoracic Outlet Syndrome/CCSVI? | Views : 325 | Replies : 1

What is wrong with MS research?

We all have seen CCSVI prevalence in MS patients oscillating from 0% to 100% according to who the researcher was. Most of us have supposed dark interests or weak skills as explanation for the discrepancies.

Recently the same has happened in other field. Kir4.1, once thought as a MS specific autoantibody, is now a theory nearly dead. (,

But the situation is ...
Read more : What is wrong with MS research? | Views : 1036 | Replies : 16


I have easy question: when is planned publishing article with results from Brave Dreams trial? And In which magazine?
Any schedule?
Thanks for answers.
Read more : Schedule | Views : 513 | Replies : 2

Stents in Poland

I was one of the first to have a jugular stent inserted in Poland - unfortunately.
My neurologist wants an MRI but the hospital won't do it without knowing the type of stent.
I have contacted Poland a number of times but without much luck.
My GP suggests trying the Polish Embassy.
Anyone have any suggestions or know the type of stent used?
Read more : Stents in Poland | Views : 687 | Replies : 9

Is this combined treatment of CCSVI with stem cells any good

i have been reading about this treatment that includes CCSVI with stem cells
its no detailed on their CCSVI protocol so wonder if they even use IVUS

Any thoughts on this as a treatment?

it claims a woman came out of a wheelchair, but that's only one person in the whole study

if money wasn't an issue for you, would you do this treatment?
Read more : Is this combined treatment of CCSVI with stem cells any good | Views : 642 | Replies : 9

Endothelial cell apotosis in jugular veins of pwMS

New, ground-breaking research from Dr. Zamboni's team:

Major endothelial dysfunction and aptosis in the intraluminal septa and defective valves of pwMS----highly deranged when compared to normals. ... 0.abstract

Why does this matter? A loss of endothelial cells means valves and veins cannot respond to hemodynamic needs of the brain--and would not function properly. Endothelial dysfunction can be overcome---but it will take more than angioplasty to deal with this. ...
Read more : Endothelial cell apotosis in jugular veins of pwMS | Views : 795 | Replies : 9

new! call centers and hiccups! don't miss it!

To all those millions of Call Center employees out there trying to call me right now:

You could get a bonus!

You could go to the head of your class!

You could end up running this very Call Center, whether in Bangalor, Toucson, or Washington. D.C. or state!

Here is the ear-worm to suggest hypnotically, unconsciously to everyone at your Call Center:

Suggest a Button. A Button you press. A Button which apparently, does nothing. ...
Read more : new! call centers and hiccups! don't miss it! | Views : 386 | Replies : 3


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