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A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Blood flow is worse in people with MS (Oct 2014 research)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216015/
Results

85 RR-MS, 83 PP-MS and 82 healthy controls were included. ΔCVF was negative in 45/85 (52.9%) RR-MS, 63/83 (75.9%) PP-MS (p = 0.01) and 11/82 (13.4%) controls (p<0.001), while MFVs on both MCAs in sitting position were significantly reduced in RR-MS and PP-MS patients than in control, particularly in EDSS≥5 subgroup (respectively, 42/50, 84% vs. 66/131, 50.3%, p<0.01 and 48.3±2 cm/s vs. 54.6±3 cm/s, p = 0.01). ...
Read more : Blood flow is worse in people with MS (Oct 2014 research) | Views : 350 | Replies : 2




CCSVI Treatment for Primary Progressive MS?

Hi sorry if Im replicating (I did do a search and go to the newbie section first).

My sister has Primary Progressive MS, I have just been to see a consultant who does CCSVI, however he said he had little experience of doing CCSVI on primary progressive MS, although they have had some positive results for people with other types of MS, he had only done one operation on one patient with Primary Progressive MS ...
Read more : CCSVI Treatment for Primary Progressive MS? | Views : 1211 | Replies : 22


Old paper from Hans Lassman

I have just found a paper from Hans Lassman from 2007. This author is quite important because he colaborates in the forefront of research, with Lucchinetti, Vanda Lennon and the people from the Mayo Clinic.

Though he has never used the term CCSVI this is what he writes in his paper:

Taken together, all these studies agree that the most initial
tissue changes in focal white matter lesions occur on a
background of mild perivenous ...
Read more : Old paper from Hans Lassman | Views : 386 | Replies : 1


study of the effect of hemoglobin on myelin

Just for those of you that love literature, here comes the next chapter of "Hemosiderin damage"

In vitro study of the direct effect of extracellular hemoglobin on myelin components.

http://www.ncbi.nlm.nih.gov/pubmed/25463632

Abstract

There is a relationship between cerebral vasculature and multiple sclerosis (MS) lesions: abnormal accumulations of iron have been found in the walls of dilated veins in MS plaques. The sources of this iron can be varied, but capillary ...
Read more : study of the effect of hemoglobin on myelin | Views : 477 | Replies : 2


New study: 83% of 552 pwMS have CCSVI

Using Zamboni's doppler technology---and including intrinsic and external vein compression--
"Balloon and go" is not the best treatment protocol. Patients must be individually assessed and treated. Most have a combo platter of internal and external vein issues. Jeff had external compression, which is why he was stented. Other vascular doctors use vein grafts, release surgery on muscles, atlas adjustments, and other methods to deal with external compression.
cheer


AIM: The aim of the present study ...
Read more : New study: 83% of 552 pwMS have CCSVI | Views : 909 | Replies : 12


They want so bad to discredit CCSVI that they support it

A book that you shouldn't read is this one:

http://onlinelibrary.wiley.com/doi/10.1 ... 3.297/full

To save you from loosing your time, I reproduce the abstract which says it all:

“Liberation treatment has no proven efficacy, may exacerbate underlying disease activity and has been complicated with SAEs"

But ....

If “Liberation treatment” can exacerbate MS, it is clear that MS is a vascular disease!!! They admit it.

I wonder if they will ...
Read more : They want so bad to discredit CCSVI that they support it | Views : 438 | Replies : 2


Testing??

Hi, for those who have been tested:

--If the IR finds stenoses in multiple veins will they all be treated??? (ie. subclavian, axillary, internal mammary...) not just IJV being treated.

--Will the IR look at other veins besides the usual suspects?

--If you were able to get insurance to help you with this cost, HOW did you do that?!?!
Read more : Testing?? | Views : 564 | Replies : 6


Cerebrovascular Reactivity

Chronically reduced Cerebrovascular Reactivity (CVR) is suspected to be the cause of neurodegeneration in MS, due to a chronic overabundance of NO, which habituates the blood vessels to being continuously expanded. The excess of NO is thought to be the result of inflammation making immune cells to release iNOS, which results in catalysis of NO. The NO overload could also result in energy loss. It may be competing with O2 absorption by mitochondria, with the ...
Read more : Cerebrovascular Reactivity | Views : 461 | Replies : 2


PubMed Commons

This is a good idea. Those authors who can get agreement with their publishers not to remain behind a paywall, can share their work here:

http://www.ncbi.nlm.nih.gov/pubmedcommons/

If a study has government funding it should belong to the people. Public libraries should have access. IMHO, it also is a grave necessity for science to progress, regardless of whether any drug companies or publishers can make profits from it.
Read more : PubMed Commons | Views : 452 | Replies : 0


 

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