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A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Clive Beggs at ISNVD 2014 ... -book.html
Venous Hemodynamics in Neurologic Disorders

Clive Beggs, Ph.D. (Centre for Infection Control and Biophysics, University of Bradford, Bradford, UK)

Abstract There is increasing evidence that the cerebral veins and sinuses play an important role in regulating fluids in the intracranial space . There is evidence that venous anomalies may contribute to the pathophysiology of several neurological conditions, including multiple sclerosis (MS) , leukoaraiosis [5, ...
Read more : Clive Beggs at ISNVD 2014 | Views : 749 | Replies : 11

the CCSVI "cult" following includes the doctors??? ... -book.html
Intervention Studies 2014 B. Therapy Trials Need to Wait. The Landscape has Changed

Kottil W. Rammohan, M.D.

Background: Numerous open label and few blinded studies have been reported on the “liberation” therapy since the original description of the disorder by Dr. Paolo Zamboni in 2008. Although most of these trials report no benefit for this endovascular intervention, Over 30,000 patients with various types and stages of ...
Read more : the CCSVI "cult" following includes the doctors??? | Views : 378 | Replies : 2

How should a ccsvi trial differ from an MS drug trial? ... -book.html
Designing an Endovascular Trial – What Elements are Essential and Why CCSVI Trials Might Differ from Disease Modifying Trials?

Kottil W. Rammohan, M.D. Background: “Liberation” of CCSVI has been associated with reports of variable efficacy both in the short as well as in the long term. Most claims of efficacy has however not withstood the scientific rigors of double-blind trials. Many of these trials have suffered ...
Read more : How should a ccsvi trial differ from an MS drug trial? | Views : 314 | Replies : 2

Foundational research is being done
Zivadinov and his colleagues published a paper on the prevalence of these abnormalities in multiple sclerosis (MS) patients in 2011. The paper is one of the top ten articles in neurology and the second most cited paper in neurology since its publication, according to Neuropenews, the news blog of the European Federation of Neurological Societies and the European Neurological Society.

Think of the citations.
The research being done ...
Read more : Foundational research is being done | Views : 296 | Replies : 0

healthy controls are not healthy controls
Inverse Relationship between Internal Jugular Vein Narrowing and Increased Brain Volumes in Healthy Individuals – Podium Presentation - #42

Chris Magnano, M.S., 1,2, Pavel Belov1, Jacqueline Krawiecki1, Steven Grisafi1, Jesper Hagemeier1, M.S., Clive, B. Beggs, Ph.D. 3, Robert Zivadinov 1,2, M.D., Ph.D.

Background: Brain volume reduction (atrophy) and internal jugular vein (IJV) narrowing have been implicated in central nervous system pathologies, but have never previously been linked.

Objectives: ...
Read more : healthy controls are not healthy controls | Views : 275 | Replies : 2

ISNVD 2014
Keynote Presentation - The Role of Blood Vessels and Inflammation in the Pathogenesis of Neurological Disorders
Dr. Paula Grammas

Session 1: A Multi-Modality Approach to Extra Cranial Venous Disease
Session Chairpersons: Dr. Robert Zivadinov

The Current Status of Ultrasound Imaging for the Screening of CCSVI
Dr. Marcello Mancini

What is the Normal Jugular Vein Valve Function?
Dr. Erica Menegatti

Prevalence of Extracranial Venous Narrowing on Catheter Venography in ...
Read more : ISNVD 2014 | Views : 358 | Replies : 0

Trauma reduces the flow through the IJVs
From an article titled, MRI Evidence for Altered Venous Drainage and Intracranial Compliance in Mild Traumatic Brain Injury, published this month:
In conclusion, the current study provides imaging-based evidence of a chronically reduced cerebral venous drainage through the internal jugular veins, an increased drainage in secondary venous channels with a concomitantly mild decreased intracranial compliance and mild increased intracranial pressure in supine subjects with a history of mTBI.
Read more : Trauma reduces the flow through the IJVs | Views : 520 | Replies : 7

Dr. Noam Alperin at ISNVD 2014
J Magn Reson Imaging. 2009 October; 30(4): 878–883.
doi: 10.1002/jmri.21925

Influence of the Compliance of the Neck Arteries and Veins on the Measurement of Intracranial Volume Change by Phase-Contrast MRI

Rong-Wen Tain, MS,1 Birgit Ertl-Wagner, MD,2 and Noam Alperin, PhD1



To assess the influence of arterial and venous vascular compliances in the neck region on the measurement of the change in intracranial volume during the cardiac ...
Read more : Dr. Noam Alperin at ISNVD 2014 | Views : 264 | Replies : 0

Endothelan discovery

Not only can endothelin issues cause circulatory problems, but now it looks like myelin repair might also be a factor:

Protein may repair brain tissue damaged by Multiple Sclerosis(10/02/14)

Multiple Sclerosis is an autoimmune disease that affects the brain and spinal cord, destroying tissue and cells along the way. Previous research and practices have found that therapies can help with relapses of MS, but cannot help repair the tissue and cells that have been affected. ...
Read more : Endothelan discovery | Views : 465 | Replies : 3

New news on MS front

I know this is out of bounds for CCSVI but I just wanted to let everyone know of this recent important development and for those who may not visit other sites.
Please excuse if this is considered an intrusion.

Bacterial toxin a potential trigger for multiple sclerosis(29/01/14)

Researchers from Weill Cornell Medical College have added to the growing body of evidence that multiple sclerosis may be triggered by a toxin produced by common foodborne ...
Read more : New news on MS front | Views : 714 | Replies : 13


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