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A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Microbleeds in the MS brain

Canadian microbiologists look at the iron around MS lesions, and link it to the vasculature and "chronic extravasation of hemoglobin", or microbleeds causing oxidative stress in the brain. This is what Dr. Zamboni proposed in 2006 in his "Big Idea" paper on the similarities of MS and venous disease. More researchers connecting MS lesions to the vasculature.

Although iron is known to be essential for the normal development and health of the central nervous system, ...
Read more : Microbleeds in the MS brain | Views : 943 | Replies : 7


Robert Zivadinov, MD, PhD, says new research may reveal how extracranial venous abnormalities contribute to various diseases as well as aging.
UB Researchers Urge Broad Study of Venous Abnormalities
Published February 27, 2014

Although their oft-cited prior study found no causal relationship between venous abnormalities in the neck and multiple sclerosis (MS), University at Buffalo neurological researchers are strongly advocating more investigation.

“We have developed a substantial body of work looking at these abnormalities in ...

KIR4.1 antibodies and CCSVI

The American Academy of Neurology will be meeting in Philadelphia from April 26-May 3. In advance of this meeting, some press releases are being sent out. Apparently, the BIG NEWS in MS research is KIR4.1 antibodies are present in about half of the plasma samples from patients with a pre-clinical diagnosis of MS patients, and this could be a diagnostic and treatment target. According to research by the Technical University in Munich-

The researchers found ...
Read more : KIR4.1 antibodies and CCSVI | Views : 1610 | Replies : 16

Dr. Zamboni at ISNVD 2014 on valves

from a slide from a presentation by Dr. Zamboni at ISNVD 2014, posted by Joan over at CCSVI Alliance facebook page
1. In healthy subjects, the IJV valve leaflets are ALWAYS mobile and open in up-right.
2. 62% of healthy controls with valve absence at least of one side suggests a progressive LOSS OF PHYLOGENETIC IMPORTANCE of such apparatus
4. The ATRIAL CONTRACTION induces ...
Read more : Dr. Zamboni at ISNVD 2014 on valves | Views : 639 | Replies : 1

Dr. Haskal at ISNVD 2014

from a slide picture that Joan put up on the CCSVI in MS facebook page
Clinical application led to early signal led to widespread dissemination in uncontrolled fashions led to medical tourism led to financial conflicts of interest led to polarizing (bidirectional) rhetoric led to mutual exaggerations led to extraordinary citizen and patient involvement

T1 and T2 steps were sidestepped

Anyone familiar with "T1 and T2 steps"? I am guessing that means research.
This is ...
Read more : Dr. Haskal at ISNVD 2014 | Views : 627 | Replies : 5

Catheter-Based, Forward-Looking, Real-Time, 3D Imaging ... 100049.htm

Researchers have developed the technology for a catheter-based device that would provide forward-looking, real-time, three-dimensional imaging from inside the heart, coronary arteries and peripheral blood vessels.

"Our device will allow doctors to see the whole volume that is in front of them within a blood vessel," said F. Levent Degertekin, a professor in the George W. Woodruff School of Mechanical Engineering at the Georgia Institute of ...
Read more : Catheter-Based, Forward-Looking, Real-Time, 3D Imaging | Views : 336 | Replies : 0

Researchers urge further study of venous abnormalities

Researchers urge further study of venous abnormalities

UB researchers who authored one of neurology’s most cited papers in the past three years are calling for more investigation into how venous abnormalities in the neck might be involved in central nervous system ... etail.html
Read more : Researchers urge further study of venous abnormalities | Views : 353 | Replies : 0

Stress matters to brain's white matter

Here is an interesting article in the LA Times that doesn't actually mention MS, let alone CCSVI, but it does mention cortisone, myelin, brain white matter, and oligodendrocytes:,0,7536685.story#axzz2t8CwkPUg

Basically the article seems to be saying (toward the end of the article) that stress and cortisone both trigger stem cells in the brain to become new myelin instead of new neurons.

The cell re-programs changes its fate, from wanting to become a neuron to wanting ...
Read more : Stress matters to brain's white matter | Views : 380 | Replies : 2

CCSVI in Meniere's Syndrome ... -book.html
Presented at ISNVD 2014
CCSVI in Meniere’s Syndrome: Diagnosis and Treatment

A. Bruno M.D., L. Califano M.D., D. Mastrangelo° M.D., M. De Vizia M.D. ° B. Bernardo° M.D. Dept of Vascular and Endovascular Surgery -GEPOS CLINIC Telese Terme (BN) ITALY - Dept of Audiology and Phoniatrics, G. Rummo Hospital Benevento ITALY

Background: Menière’s Syndrome described in 1861 by Prospero Menière. The disease is characterized by the ...
Read more : CCSVI in Meniere's Syndrome | Views : 602 | Replies : 2

Clive Beggs at ISNVD 2014 ... -book.html
Venous Hemodynamics in Neurologic Disorders

Clive Beggs, Ph.D. (Centre for Infection Control and Biophysics, University of Bradford, Bradford, UK)

Abstract There is increasing evidence that the cerebral veins and sinuses play an important role in regulating fluids in the intracranial space . There is evidence that venous anomalies may contribute to the pathophysiology of several neurological conditions, including multiple sclerosis (MS) , leukoaraiosis [5, ...
Read more : Clive Beggs at ISNVD 2014 | Views : 809 | Replies : 11


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