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A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Stress matters to brain's white matter

Here is an interesting article in the LA Times that doesn't actually mention MS, let alone CCSVI, but it does mention cortisone, myelin, brain white matter, and oligodendrocytes:,0,7536685.story#axzz2t8CwkPUg

Basically the article seems to be saying (toward the end of the article) that stress and cortisone both trigger stem cells in the brain to become new myelin instead of new neurons.

The cell re-programs changes its fate, from wanting to become a neuron to wanting ...
Read more : Stress matters to brain's white matter | Views : 380 | Replies : 2

CCSVI in Meniere's Syndrome ... -book.html
Presented at ISNVD 2014
CCSVI in Meniere’s Syndrome: Diagnosis and Treatment

A. Bruno M.D., L. Califano M.D., D. Mastrangelo° M.D., M. De Vizia M.D. ° B. Bernardo° M.D. Dept of Vascular and Endovascular Surgery -GEPOS CLINIC Telese Terme (BN) ITALY - Dept of Audiology and Phoniatrics, G. Rummo Hospital Benevento ITALY

Background: Menière’s Syndrome described in 1861 by Prospero Menière. The disease is characterized by the ...
Read more : CCSVI in Meniere's Syndrome | Views : 604 | Replies : 2

Clive Beggs at ISNVD 2014 ... -book.html
Venous Hemodynamics in Neurologic Disorders

Clive Beggs, Ph.D. (Centre for Infection Control and Biophysics, University of Bradford, Bradford, UK)

Abstract There is increasing evidence that the cerebral veins and sinuses play an important role in regulating fluids in the intracranial space . There is evidence that venous anomalies may contribute to the pathophysiology of several neurological conditions, including multiple sclerosis (MS) , leukoaraiosis [5, ...
Read more : Clive Beggs at ISNVD 2014 | Views : 812 | Replies : 11

the CCSVI "cult" following includes the doctors??? ... -book.html
Intervention Studies 2014 B. Therapy Trials Need to Wait. The Landscape has Changed

Kottil W. Rammohan, M.D.

Background: Numerous open label and few blinded studies have been reported on the “liberation” therapy since the original description of the disorder by Dr. Paolo Zamboni in 2008. Although most of these trials report no benefit for this endovascular intervention, Over 30,000 patients with various types and stages of ...
Read more : the CCSVI "cult" following includes the doctors??? | Views : 386 | Replies : 2

How should a ccsvi trial differ from an MS drug trial? ... -book.html
Designing an Endovascular Trial – What Elements are Essential and Why CCSVI Trials Might Differ from Disease Modifying Trials?

Kottil W. Rammohan, M.D. Background: “Liberation” of CCSVI has been associated with reports of variable efficacy both in the short as well as in the long term. Most claims of efficacy has however not withstood the scientific rigors of double-blind trials. Many of these trials have suffered ...
Read more : How should a ccsvi trial differ from an MS drug trial? | Views : 327 | Replies : 2

Foundational research is being done
Zivadinov and his colleagues published a paper on the prevalence of these abnormalities in multiple sclerosis (MS) patients in 2011. The paper is one of the top ten articles in neurology and the second most cited paper in neurology since its publication, according to Neuropenews, the news blog of the European Federation of Neurological Societies and the European Neurological Society.

Think of the citations.
The research being done ...
Read more : Foundational research is being done | Views : 306 | Replies : 0

healthy controls are not healthy controls
Inverse Relationship between Internal Jugular Vein Narrowing and Increased Brain Volumes in Healthy Individuals – Podium Presentation - #42

Chris Magnano, M.S., 1,2, Pavel Belov1, Jacqueline Krawiecki1, Steven Grisafi1, Jesper Hagemeier1, M.S., Clive, B. Beggs, Ph.D. 3, Robert Zivadinov 1,2, M.D., Ph.D.

Background: Brain volume reduction (atrophy) and internal jugular vein (IJV) narrowing have been implicated in central nervous system pathologies, but have never previously been linked.

Objectives: ...
Read more : healthy controls are not healthy controls | Views : 286 | Replies : 2

ISNVD 2014
Keynote Presentation - The Role of Blood Vessels and Inflammation in the Pathogenesis of Neurological Disorders
Dr. Paula Grammas

Session 1: A Multi-Modality Approach to Extra Cranial Venous Disease
Session Chairpersons: Dr. Robert Zivadinov

The Current Status of Ultrasound Imaging for the Screening of CCSVI
Dr. Marcello Mancini

What is the Normal Jugular Vein Valve Function?
Dr. Erica Menegatti

Prevalence of Extracranial Venous Narrowing on Catheter Venography in ...
Read more : ISNVD 2014 | Views : 393 | Replies : 0

Trauma reduces the flow through the IJVs
From an article titled, MRI Evidence for Altered Venous Drainage and Intracranial Compliance in Mild Traumatic Brain Injury, published this month:
In conclusion, the current study provides imaging-based evidence of a chronically reduced cerebral venous drainage through the internal jugular veins, an increased drainage in secondary venous channels with a concomitantly mild decreased intracranial compliance and mild increased intracranial pressure in supine subjects with a history of mTBI.
Read more : Trauma reduces the flow through the IJVs | Views : 550 | Replies : 7

Dr. Noam Alperin at ISNVD 2014
J Magn Reson Imaging. 2009 October; 30(4): 878–883.
doi: 10.1002/jmri.21925

Influence of the Compliance of the Neck Arteries and Veins on the Measurement of Intracranial Volume Change by Phase-Contrast MRI

Rong-Wen Tain, MS,1 Birgit Ertl-Wagner, MD,2 and Noam Alperin, PhD1



To assess the influence of arterial and venous vascular compliances in the neck region on the measurement of the change in intracranial volume during the cardiac ...
Read more : Dr. Noam Alperin at ISNVD 2014 | Views : 296 | Replies : 0


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