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A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Trauma reduces the flow through the IJVs
From an article titled, MRI Evidence for Altered Venous Drainage and Intracranial Compliance in Mild Traumatic Brain Injury, published this month:
In conclusion, the current study provides imaging-based evidence of a chronically reduced cerebral venous drainage through the internal jugular veins, an increased drainage in secondary venous channels with a concomitantly mild decreased intracranial compliance and mild increased intracranial pressure in supine subjects with a history of mTBI.
Read more : Trauma reduces the flow through the IJVs | Views : 547 | Replies : 7

Dr. Noam Alperin at ISNVD 2014
J Magn Reson Imaging. 2009 October; 30(4): 878–883.
doi: 10.1002/jmri.21925

Influence of the Compliance of the Neck Arteries and Veins on the Measurement of Intracranial Volume Change by Phase-Contrast MRI

Rong-Wen Tain, MS,1 Birgit Ertl-Wagner, MD,2 and Noam Alperin, PhD1



To assess the influence of arterial and venous vascular compliances in the neck region on the measurement of the change in intracranial volume during the cardiac ...
Read more : Dr. Noam Alperin at ISNVD 2014 | Views : 289 | Replies : 0

Endothelan discovery

Not only can endothelin issues cause circulatory problems, but now it looks like myelin repair might also be a factor:

Protein may repair brain tissue damaged by Multiple Sclerosis(10/02/14)

Multiple Sclerosis is an autoimmune disease that affects the brain and spinal cord, destroying tissue and cells along the way. Previous research and practices have found that therapies can help with relapses of MS, but cannot help repair the tissue and cells that have been affected. ...
Read more : Endothelan discovery | Views : 492 | Replies : 3

New news on MS front

I know this is out of bounds for CCSVI but I just wanted to let everyone know of this recent important development and for those who may not visit other sites.
Please excuse if this is considered an intrusion.

Bacterial toxin a potential trigger for multiple sclerosis(29/01/14)

Researchers from Weill Cornell Medical College have added to the growing body of evidence that multiple sclerosis may be triggered by a toxin produced by common foodborne ...
Read more : New news on MS front | Views : 729 | Replies : 13

Anyone know of a procedure involving a cutting balloon?

Want to find some cases involving use of a cutting balloon in the internal jugular vein. Found several for dialysis patients but none so far for the IJV.

Want to prepare information before meeting neurosurgeon for next office visit.

Read more : Anyone know of a procedure involving a cutting balloon? | Views : 390 | Replies : 10

Is this the beginning of the end for Big Pharma?

I just read an article about Indian Pharmaceutical companies producing cheap generics and successfully repudiating the patents of some of the largest pharmaceutical companies in the world. It did not mention MS drugs but the principle is the same and if India can do it why can't we all?

"At the time, Bayer was selling the drugs at 280,000 rupees (£2,743) a month versus Natco's 8,800 rupees (£86.20), and reaching just two percent of the ...
Read more : Is this the beginning of the end for Big Pharma? | Views : 607 | Replies : 7

KIR4.1 and CCSVI response

In 2012 a german team identified an immunoglobin, anti-KIR4.1, in a subset of MS patients (47%, see ... t=Abstract). Recently another team has confirmed this situation (

The situation looks very similar to what happened with Neuromyelitis optica and AntiAQP4. Maybe there are two different multiple sclerosis. And this is crucial to know the impact of CCSVI procedures and to analyse its ...
Read more : KIR4.1 and CCSVI response | Views : 448 | Replies : 2


Cross-posted to here because I would have missed it, being as I don't read a lot elsewhere.

They appear to be proving a method of helping primary and secondary progressives. Very safe, does not alter immune system. Targets a human endogenous retro-virus implicated in our favorite problem. Does anyone here know the difference between "MS" and CIDP?

Seems they are running phase 2 now.

Anyway, here is their newsletter:

Read more : HERVs | Views : 314 | Replies : 0

Never-Ending Traumatic Stress Disorder ... crazy.html

Worth the read in a crushingly painful sort of way.
Read more : Never-Ending Traumatic Stress Disorder | Views : 301 | Replies : 1


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