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A board to discuss future MS therapies in early stage (Phase I or II) trials.

What do you all think of these studies of myelin repair?

It may be better to read on link page, but i copy and pasted here as well ... sclerosis/

To stimulate myelin repair or remyelination in MS patients, researchers are focusing on approaches that promote OPC migration, survival, and maturation. The past several years of research have produced a number of druggable targets, which fall into two broad categories: molecules that negatively regulate OPC function and molecules that ...
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Erythropoietin-based peptide.....dramatic results

Novel Peptide Shows Promise for a Broad 
Spectrum of Inflammation-Related Disorders
Neurology Reviews. 2015 October;23(10):27.

More »
A peptide derived from erythropoietin (EPO) demonstrated potent clinical benefits in animal models of multiple sclerosis (MS) without inducing hematologic side effects, according to research published online ahead of print August 14 in Neurotherapeutics. The peptide, JM-4, reduced disability and protected against demyelination in mice with experimental autoimmune encephalomyelitis (EAE). Unlike full-length EPO, JM-4 did not elevate hematocrit ...
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NABILONE - Have you tried it for pain relief?

My older brother has chronic back pain (does not have MS) and is using this drug with some success. I have been doing research and it appears some with MS pain do well on it. As there can be some serious side effects (like most prescription drugs) and it can be habit forming, I am hesitant but considering trying it to see if I experience any pain relief. Just wondering if you have tried it ...
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Hi I just read about a medication named lemtrada by the Genzyme company. It sounds better than some I was wondering if anyone is on it.

Read more : Lemtrada | Views : 1749 | Replies : 2

Starts a dendritic cell trial adapted to MS

The Spanish Agency for Medicines and Health Products (AEMPS) has approved the first clinical trial of a specific antigen therapy based on dendritic cells adapted for patients with MS and NMO, (also called Devic's disease).

This research, which will be led by Pablo Villoslada and Daniel Benitez from the Clinic Hospital of Barcelona, is driven by the Grupo de Afectados de Esclerosis Múltiple (GAEM), and has the support of the Obra Social La Caixa.

The ...
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MediciNova announces update on phase 2b trial

MediciNova has announced that the ongoing clinical trial of MN-166 (ibudilast) in patients with progressive multiple sclerosis (PMS) has finished the randomisation of 255 patients, exceeding the initial goal of 250 patients........ Read More -
Read more : MediciNova announces update on phase 2b trial | Views : 1940 | Replies : 0

Metrics for evaluating therapies

MS patients try a long list of things to slow or reverse the march of our disease. How do we know what's working and what isn't? EDSS is a crude metric that measures changes over years - but many don't have the patience to continue with things that may or may not have an impact.

It seems to me that more sensitive metrics may be possible if we accept that metrics have to be individualized ...
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HI Friends a common drug used for treating athlete's foot and another for alleviating eczema may be useful therapies for ms believe
read more from
Read more : RE ATHLETE'S FOOT DRUG MAY BE MS THERAPY | Views : 1745 | Replies : 0


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