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A board to discuss future MS therapies in early stage (Phase I or II) trials.


From ... ODDISJ.pdf

Niacin plays an important role in myelination associated with the synthesis of cerebrosides which contain high levels of long chain fatty acid . Niacin activates the G-protein coupled receptor GPR109a to produce the IDO- inducing tolerogenic prostaglandins PGE (2) and PGD (2). PGD (2) is converted to the anti-inflammatory prostaglandin. These prostaglandins exert potent anti-inflammatory activities . Niaspan treatment experimental autoimmune encephalomyelitis (EAE) mice ...
Read more : Niacin | Views : 1799 | Replies : 25

Health Canada blocks dying patients from access to drug

just want to show what health Canada is like .

Health Canada blocks dying patients from access to drug

Specialist 'appalled and angry' with federal agency ... enied.html
Read more : Health Canada blocks dying patients from access to drug | Views : 570 | Replies : 0

Delay Drugs One Year OR ....

Delay Drugs One Year OR Reinforce your Healing WITH the Drugs by Optimizing your Nutrition and Treating the BLOOD REFLUX

On the site Alicia asked the following question:

Tues June 4 2013 General Discussion

"I have a question for you. How can anyone possibly tell if a disease modifying
drug is preventing relapses if no one really knows how MS works, everyone's MS
is different and it is impossible to predict when and how ...
Read more : Delay Drugs One Year OR .... | Views : 1028 | Replies : 14

Crowdsourcing Clinical Trials ... dsourcing/

This concept gives new hope to the thought that therapies that cannot be patented could still gain the statistically significant status needed to be accepted by the medical community.

There is a wealth of anecdotal data supporting things like:

Wheldon Protocol (ABX antibiotic regimens)
Procarin / histamine (Prokarin)
Low Dose Naltrexone (LDN)
Swank diet & supplement regimen

But these potentially life-altering therapies aren't even ...
Read more : Crowdsourcing Clinical Trials | Views : 600 | Replies : 1

"The Holy Grail" -- Continuation of Nanoparticle research

Anyone else excited about this? Some results from the first clinical trial based on the nanoparticle research first published this last November. ... 144312.htm


"A phase 1 clinical trial for the first treatment to reset the immune system of multiple sclerosis (MS) patients showed the therapy was safe and dramatically reduced patients' immune systems' reactivity to myelin by 50 to 75 percent, according to new Northwestern Medicine ...
Read more : "The Holy Grail" -- Continuation of Nanoparticle research | Views : 1221 | Replies : 1

CCSVI Evolved and the Missing Infectious Link

Contrary to recent “reports”, CCSVI isn’t “dead”. It is being
refined and rethought and is very much alive.

Dr. Zamboni’s groundbreaking insight poses two distinct problems.
First, the reflux of veinous blood into the central nervous system must be
halted (at best) or minimized. Second, the injured tissue must be healed.

Recent observations about cranial fluid dynamics, the possibility that cerebrospinal
fluid build-up can "pressure" venous blood circulation leading to a blood
reflux, implies that ...
Read more : CCSVI Evolved and the Missing Infectious Link | Views : 595 | Replies : 0

Can Anti-HIV Drugs Stop MS?

A clinical trial now underway at Queen Mary University in London, England, called be INSPIRE trial (click here), is attempting to use Raltegravir to treat MS patients. Researchers hope that the drug will deactivate any activated retroviral material in the DNA of MS patients, while perhaps also combating EBV, and thus stop multiple sclerosis in its tracks. Another group of researchers in Switzerland are trying to accomplish the same outcome using an experimental drug that ...
Read more : Can Anti-HIV Drugs Stop MS? | Views : 1646 | Replies : 5

Targeting estrogen receptor β in microglia and T cells

Very early stages, but I did not see any reference to it on TIMS.
Targeting estrogen receptor β in microglia and T cells to treat experimental autoimmune encephalomyelitis
A therapeutic goal in the treatment of certain CNS diseases, including multiple sclerosis, amyotrophic lateral sclerosis, and Parkinson disease, is to down-regulate inflammatory pathways. Inflammatory molecules produced by microglia are responsible for removal of damaged neurons, but can cause collateral damage to normal neurons located close ...
Read more : Targeting estrogen receptor β in microglia and T cells | Views : 586 | Replies : 0


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