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A board to discuss future MS therapies in early stage (Phase I or II) trials.

CCSVI Evolved and the Missing Infectious Link

Contrary to recent “reports”, CCSVI isn’t “dead”. It is being
refined and rethought and is very much alive.

Dr. Zamboni’s groundbreaking insight poses two distinct problems.
First, the reflux of veinous blood into the central nervous system must be
halted (at best) or minimized. Second, the injured tissue must be healed.

Recent observations about cranial fluid dynamics, the possibility that cerebrospinal
fluid build-up can "pressure" venous blood circulation leading to a blood
reflux, implies that ...
Read more : CCSVI Evolved and the Missing Infectious Link | Views : 770 | Replies : 1

Can Anti-HIV Drugs Stop MS?

A clinical trial now underway at Queen Mary University in London, England, called be INSPIRE trial (click here), is attempting to use Raltegravir to treat MS patients. Researchers hope that the drug will deactivate any activated retroviral material in the DNA of MS patients, while perhaps also combating EBV, and thus stop multiple sclerosis in its tracks. Another group of researchers in Switzerland are trying to accomplish the same outcome using an experimental drug that ...
Read more : Can Anti-HIV Drugs Stop MS? | Views : 1704 | Replies : 5

Targeting estrogen receptor β in microglia and T cells

Very early stages, but I did not see any reference to it on TIMS.
Targeting estrogen receptor β in microglia and T cells to treat experimental autoimmune encephalomyelitis
A therapeutic goal in the treatment of certain CNS diseases, including multiple sclerosis, amyotrophic lateral sclerosis, and Parkinson disease, is to down-regulate inflammatory pathways. Inflammatory molecules produced by microglia are responsible for removal of damaged neurons, but can cause collateral damage to normal neurons located close ...
Read more : Targeting estrogen receptor β in microglia and T cells | Views : 597 | Replies : 0


I have just started Tecfidera after four years on Avonex. The side effects of Avonex never let up. I'd love to get in touch with anyone else who is taking Tecfidera. So far, I'm doing very well--but I'm still on half doses. Next week I start full doses.
Read more : Tecfidera | Views : 7197 | Replies : 46

4-ap side effects

My mum started 4-ap about a week ago ( I don't know the dose sorry ). She was on a trial that her neuro put her on for a week. After having 1 tab a day, they changed her to 2. Tonight, a couple of hours after the tablet, I went to visit her and she was shaking uncontrollably, she was incredibly confused and wasn't sure who I was and where she was, she kept ...
Read more : 4-ap side effects | Views : 644 | Replies : 1


I am thinking about switching to BG-12. I was hoping someone else might have some insight. Any side effects?
Read more : BG-12 | Views : 1725 | Replies : 4

Olesoxime (previously known as TRO19622)

I am not sure if this has been posted before
A Phase 1b study in RRMS patients is starting in three MS reference centers in France

About Olesoxime
Olesoxime (previously known as TRO19622) is a mitochondrial targeted, cholesterol-like compound that is currently undergoing Phase II clinical evaluation for the treatment of spinal muscular atrophy. Olesoxime's safety and tolerability has already been tested in 15 clinical trials involving 968 patients or healthy volunteers and has proved ...
Read more : Olesoxime (previously known as TRO19622) | Views : 833 | Replies : 0


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