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A board to discuss future MS therapies in early stage (Phase I or II) trials.

Bg12 after gilenya and tysabri

Hi all, Just wondering if anyone is in the same position as me.
I am considering switching from gilenya to bg12.
I have been on gilenya for 8 months.
Prior to this I was on tysabri for 14/15 months, but came back JC+.
Prior to that, had been on coax one for over a year, and before that, beta freon for several years.
I was diagnosed with MS in 1991 (22 years ago!)

The reason ...
Read more : Bg12 after gilenya and tysabri | Views : 1540 | Replies : 3

aubagio sleepy pill???

I have been taking Aubagio every night for 2 weeks now. I have had none of the side affects they listed but i have been VERY tired to the point of wanting to nap or falling asleep at 9pm. i workout, eat healthy, take all the vitamins i should plus more. Has anyone else had this rip vanwinkle affect??
Read more : aubagio sleepy pill??? | Views : 903 | Replies : 2

SPMS drug?

Is anyone aware of any drug being used for spms?
Read more : SPMS drug? | Views : 682 | Replies : 0

Patient enrolment completed in first study of olesoxime

Patient enrolment completed in first study of olesoxime in relapsing remitting MS

Trophos SA announced today that they have completed enrollment in the Translate MS-Repair Phase Ib multiple sclerosis (MS) trial.

The trial is a randomized, placebo controlled, Phase Ib study in multiple sclerosis (MS) patients treated with Trophos' olesoxime as an add-on therapy to Interferon beta. In three months, 44 patients have been recruited in three investigational sites in France. The first subject was ...
Read more : Patient enrolment completed in first study of olesoxime | Views : 666 | Replies : 0

Botox for MS Hug

Has anybody tried Botox injections for the MS Hug ? Was it successful or not ?
Read more : Botox for MS Hug | Views : 687 | Replies : 1

Initiation of a cooperative phase 2b trial of MN-166

Initiation of a cooperative phase 2b trial of MN-166 in progressive MS announced

MediciNova, Inc.announced the funding and regulatory approvals of a NIH-based grant for a Phase 2b trial of MN-166 (ibudilast) in subjects with progressive multiple sclerosis (progressive MS). The principal investigator will be Robert Fox, M.D., M.S., FAAN, Staff Neurologist at the Mellen Center for Multiple Sclerosis at Cleveland Clinic.

The grant is for a funded cooperative effort by the NeuroNEXT clinical trial ...
Read more : Initiation of a cooperative phase 2b trial of MN-166 | Views : 578 | Replies : 0

Myelin peptide transdermal patch

Small Study Suggests Possible Benefit for Skin Patch to Reduce Immune Activity in Multiple Sclerosis ... x?nid=8012

Polish researchers reported results of a small clinical trial in which a skin patch containing myelin peptides (portions of the substance that insulates nerve fibers and is a target of the immune attack on the brain and spinal cord in MS) were administered to 20 people with relapsing-remitting MS via a ...
Read more : Myelin peptide transdermal patch | Views : 1502 | Replies : 3


Etifoxine to target, a protein referred to as mitochondrial translocator protein (TSPO), had been previously identified but not linked to MS, an autoimmune disease that strips the protective fatty coating off nerve fibers of the brain and spinal cord.
Read more : Etifoxine | Views : 691 | Replies : 0

Patient enrollment in AVP-923 PRIME Study completed

Avanir Pharmaceuticals, Inc. announced completion of patient enrollment in the company's phase II, placebo controlled study testing three doses of AVP-923 for the treatment of central neuropathic pain in multiple sclerosis. Top-line results from this study are expected in the fourth calendar quarter of 2013.

"Final completion of enrollment in PRIME is an important milestone in the AVP-923 development pathway," said Joao Siffert, MD, chief scientific officer at Avanir. "We are looking forward to the ...
Read more : Patient enrollment in AVP-923 PRIME Study completed | Views : 710 | Replies : 0


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