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A board to discuss future MS therapies in early stage (Phase I or II) trials.

Positive top-line phase II results of Ofatumumab in MS

Genmab A/S announced top-line results from a Phase II study of the subcutaneous formulation of
ofatumumab in relapsing-remitting multiple sclerosis (RRMS).

A total of 232 subjects with RRMS were randomized in the study. There was a
clear separation from placebo on the cumulative number of new gadolinium
enhancing lesions (active brain lesions) over a period of 12 weeks in subjects
treated with all doses of ofatumumab compared to subjects treated with placebo
. ...
Read more : Positive top-line phase II results of Ofatumumab in MS | Views : 1005 | Replies : 0


seeva :twisted:
Read more : NEW DRUG FOR REPAIR DAMAGED MYELIN | Views : 1834 | Replies : 1

intrathecal methotrexate

Any PP tried intrathecal methotrexate? The drug can be administered off-label and some studies showed that it could halt the progression of the disease.
Read more : intrathecal methotrexate | Views : 643 | Replies : 0

Bg12 after gilenya and tysabri

Hi all, Just wondering if anyone is in the same position as me.
I am considering switching from gilenya to bg12.
I have been on gilenya for 8 months.
Prior to this I was on tysabri for 14/15 months, but came back JC+.
Prior to that, had been on coax one for over a year, and before that, beta freon for several years.
I was diagnosed with MS in 1991 (22 years ago!)

The reason ...
Read more : Bg12 after gilenya and tysabri | Views : 1575 | Replies : 3

aubagio sleepy pill???

I have been taking Aubagio every night for 2 weeks now. I have had none of the side affects they listed but i have been VERY tired to the point of wanting to nap or falling asleep at 9pm. i workout, eat healthy, take all the vitamins i should plus more. Has anyone else had this rip vanwinkle affect??
Read more : aubagio sleepy pill??? | Views : 932 | Replies : 2

SPMS drug?

Is anyone aware of any drug being used for spms?
Read more : SPMS drug? | Views : 694 | Replies : 0

Patient enrolment completed in first study of olesoxime

Patient enrolment completed in first study of olesoxime in relapsing remitting MS

Trophos SA announced today that they have completed enrollment in the Translate MS-Repair Phase Ib multiple sclerosis (MS) trial.

The trial is a randomized, placebo controlled, Phase Ib study in multiple sclerosis (MS) patients treated with Trophos' olesoxime as an add-on therapy to Interferon beta. In three months, 44 patients have been recruited in three investigational sites in France. The first subject was ...
Read more : Patient enrolment completed in first study of olesoxime | Views : 675 | Replies : 0

Botox for MS Hug

Has anybody tried Botox injections for the MS Hug ? Was it successful or not ?
Read more : Botox for MS Hug | Views : 698 | Replies : 1


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