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A board to discuss future MS therapies in early stage (Phase I or II) trials.

Can Anti-HIV Drugs Stop MS?

A clinical trial now underway at Queen Mary University in London, England, called be INSPIRE trial (click here), is attempting to use Raltegravir to treat MS patients. Researchers hope that the drug will deactivate any activated retroviral material in the DNA of MS patients, while perhaps also combating EBV, and thus stop multiple sclerosis in its tracks. Another group of researchers in Switzerland are trying to accomplish the same outcome using an experimental drug that ...
Read more : Can Anti-HIV Drugs Stop MS? | Views : 1742 | Replies : 5

Targeting estrogen receptor β in microglia and T cells

Very early stages, but I did not see any reference to it on TIMS.
Targeting estrogen receptor β in microglia and T cells to treat experimental autoimmune encephalomyelitis
A therapeutic goal in the treatment of certain CNS diseases, including multiple sclerosis, amyotrophic lateral sclerosis, and Parkinson disease, is to down-regulate inflammatory pathways. Inflammatory molecules produced by microglia are responsible for removal of damaged neurons, but can cause collateral damage to normal neurons located close ...
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I have just started Tecfidera after four years on Avonex. The side effects of Avonex never let up. I'd love to get in touch with anyone else who is taking Tecfidera. So far, I'm doing very well--but I'm still on half doses. Next week I start full doses.
Read more : Tecfidera | Views : 7574 | Replies : 46

4-ap side effects

My mum started 4-ap about a week ago ( I don't know the dose sorry ). She was on a trial that her neuro put her on for a week. After having 1 tab a day, they changed her to 2. Tonight, a couple of hours after the tablet, I went to visit her and she was shaking uncontrollably, she was incredibly confused and wasn't sure who I was and where she was, she kept ...
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I am thinking about switching to BG-12. I was hoping someone else might have some insight. Any side effects?
Read more : BG-12 | Views : 1732 | Replies : 4

Olesoxime (previously known as TRO19622)

I am not sure if this has been posted before
A Phase 1b study in RRMS patients is starting in three MS reference centers in France

About Olesoxime
Olesoxime (previously known as TRO19622) is a mitochondrial targeted, cholesterol-like compound that is currently undergoing Phase II clinical evaluation for the treatment of spinal muscular atrophy. Olesoxime's safety and tolerability has already been tested in 15 clinical trials involving 968 patients or healthy volunteers and has proved ...
Read more : Olesoxime (previously known as TRO19622) | Views : 842 | Replies : 0


recently diagnosed with PPMS.
I live in Ireland but can travel. If there is any other procedure that can help with PPMS.
Read more : ccsvi | Views : 994 | Replies : 4

drug study results

In this video from TED Dr. Goldacre expalins why it is hard to get the real results from these studies. ... n=20130213
Read more : drug study results | Views : 833 | Replies : 3

Has anyone here had BOTOX injections in the bladder ?

a uro-neurologist has offered me this treatment option of having BOTOX injections in the bladder to improve bladder incontinence symptoms,
he said it improves MS patients urgency, frequency and control of their bladder,
you are under a local anaesthetic for 45 minutes during the injections, and the effects last 6-12 months before requiring further injections,

this 'trial' seems promising and as i have this option for treatment am very tempted to go ahead with the ...
Read more : Has anyone here had BOTOX injections in the bladder ? | Views : 2702 | Replies : 20


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