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A board to discuss future MS therapies in early stage (Phase I or II) trials.

Rituxan Phase III for PPMS

I thought this was a typo a week or two ago when I saw mention of the latest Rituxan trial for PPMS being a Phase III trial, but this exerpt from a press release today says it again, so I guess it's not a typo.

Genentech Announces Full Year and Fourth Quarter 2005 Results

Tuesday January 10, 4:29 pm ET

Record Annual Revenues of $6.6 Billion Drive Year-Over-Year Non-GAAP EPS Growth of 54 Percent

Read more : Rituxan Phase III for PPMS | Views : 1922 | Replies : 0


Here's a drug (Sanofi-aventis' HP184) in the early stages that might be helpful for MS and other conditions.

Tireless quest for a cure, Lorenzo-style

Globe & Mail - January 9, 2006...

Of particular interest is a drug called HP184, a sodium and potassium channel blocker that has been tested on spinal cord patients. When Jacob's parents brought the drug, made by Sanofi-aventis, to the attention of doctors, none had heard of it.

"They're very proactive, ...
Read more : HP184 | Views : 2448 | Replies : 1

A new angle: using RNA

This sounds like a different way of treating MS that has potential.

A Novel Method of Modifying Immune Responses By Vaccination With Lipiodol-siRNA Mixtures.

J Transl Med. 2006 Jan 3;4(1):2
Ichim TE, Popov IA, Riordan NH, Izadi H, Zhong Z, Yijian L, Sher S, Oleinik EK.

ABSTRACT: The dendritic cell (DC) possesses the ability to stimulate both T helper 1 (Th1) and Th2 responses depending on activation stimuli. Although it is ...
Read more : A new angle: using RNA | Views : 1391 | Replies : 0


EPO is in pre-clinical studies for MS. This abstract talks about a modified version that would possibly have fewer side effects...

Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis.

J Neuroimmunol. 2005 Dec 6;
Savino C, Pedotti R, Baggi F, Ubiali F, Gallo B, Nava S, Bigini P, Barbera S, Fumagalli E, Mennini T, Vezzani A, Rizzi M, Coleman T, Cerami A, Brines M, Ghezzi P, Bianchi R.
"Mario Negri" ...
Read more : EPO | Views : 1622 | Replies : 0

Nutra Pharma Reports Discovery of New Gene Involved in MS

This came out today!

BOYNTON BEACH, Fla.--(BUSINESS WIRE)--Dec. 19, 2005--Nutra Pharma Corp., (OTCBB:NPHC) a biotechnology holding company that owns rights to intellectual property related to the development of drugs for HIV and Multiple Sclerosis (MS) has announced that their continuing microarray studies have identified a new gene involved in the disease process of Multiple Sclerosis. Although the gene and some of its functions are already known, this is the first evidence of involvement with the ...
Read more : Nutra Pharma Reports Discovery of New Gene Involved in MS | Views : 1606 | Replies : 0


This is old news, but Bayhill just decided to do this press release I guess...

Scientists Demonstrate Investigational MS Drug Down Regulates the Underlying Cause Believed Responsible for Multiple Sclerosis

BUSINESS WIRE - Dec. 19, 2005 - Scientists at Bayhill Therapeutics report promising findings for an investigational multiple sclerosis (MS) drug, BHT-3009, which represents a novel DNA plasmid-based approach for the treatment of the life-threatening disease.

In a number of patients with myelin basic protein ...
Read more : BHT-3009 | Views : 2693 | Replies : 1

List of current drug trials

I saw this list on another MS board forum. I am sorry if this is a repeat. It was first available in September, therefore, they are probably new drugs to be added. The credit for putting this list together should go to Jay.

"MS Disease-Modifying Meds"

( Approved Meds )

1. Avonex (interferon beta 1a)
2. Betaseron (interferon beta 1b)
3. Copaxone (glatiramir acetate)
4. Novantrone (mitoxantrone)
5. Rebif (interferon beta 1a)

Treatments ( not ...
Read more : List of current drug trials | Views : 2555 | Replies : 1

Questions about FTY720

I’m trying to decide if I will participate in the phase III clinical trial of FTY720. I need to decide now, even if the clinical trial should only begin in March. That’s because there must be a 3 month wash-out period (no interferon or glatiramer acetate) before the screening visit for the Phase 3 FTY720 study. I’ve been on Copaxone for 4.5 years but I had 2 relapses this year. Like most people here, I ...
Read more : Questions about FTY720 | Views : 11610 | Replies : 31


I hope I haven't posted this before:

Marijuana derivatives or "cannabinoids" taken for one year for the treatment of multiple sclerosis (MS) may reduce muscle spasms and other aspects of disability, results of a UK study suggest.

Dr. J. P. Zajicek, from Peninsula Medical School in Plymouth and colleagues previously reported that cannabinoids taken for 14 weeks appeared to improve mobility and patients' perception of their MS symptoms. In an extension study, 80 percent of ...
Read more : cannaboids | Views : 1724 | Replies : 1


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