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A board to discuss future MS therapies in early stage (Phase I or II) trials.


Dear all,

This is from the Boston Cure Project site:

art writes "No link for this one, but Novartis sent a letter in April to investigators participating in their trial of FTY720 in people undergoing transplant patients. It seems that there have been 13 cases of macular edema (swelling of the center of the retina) out of 1600 transplant cases. Five of these had no other risk factors and the Opthamology Advisory Group has confirmed ...
Read more : FTY720 | Views : 1559 | Replies : 1


Some recent research which mentions FTY720

Bromley ... d=rssfeeds
Read more : FTY720 | Views : 1542 | Replies : 1

Update on Neuren

Dear all,

I recently posted on a NZ company called Neuren. They appear to be doing some interesting work and have some potentially useful drugs in the pipeline. The following link provides an update on some of their drugs. Timescales as usual are long (as if always the case with anything connected to MS).

Read more : Update on Neuren | Views : 1300 | Replies : 0

A new phase II trial starting

Millennium Initiates Phase II Clinical Trial in Patients With Multiple Sclerosis

July 11 - PRNewswire-FirstCall - Millennium Pharmaceuticals, Inc. today announced the initiation of a multicenter phase II clinical trial of MLN1202 in approximately 40 patients with relapsing-remitting multiple sclerosis (MS), the most common form of the disease. MLN1202, a novel humanized monoclonal antibody, is designed to block CCR2 chemokine receptors and prevent the infiltration of immune cells into inflammatory sites. The CCR2 chemokine pathway ...
Read more : A new phase II trial starting | Views : 1473 | Replies : 0

Neuren - NZ company

Dear all,

In March it was reported that the US Army were taking up a brain injury drug which was in early trials. The company behind the drug are Neuren. A link to their website is attached.

The company are developing some interesting products relevant to MS (see under Technology and Development Pipeline). Many of the drugs are neuro-protective, but they also have a peptide in development to ...
Read more : Neuren - NZ company | Views : 1309 | Replies : 0

High dose Prednisone - 1250 mg per day

Has anyone been on Copaxone with 1250 mg per day of prednisone? I'm newly diagnosed and have been asked to join a trial. I'm trying to find info about prednisone doses that high and have not had much luck.
Read more : High dose Prednisone - 1250 mg per day | Views : 2748 | Replies : 2

Two oral drugs in trial

Dear all,

The US NMSS website provides info on two oral drugs in trial - FY720 (Dignan has already posted) and another with an unpronouncable name. ... June21.asp

Read more : Two oral drugs in trial | Views : 1635 | Replies : 1

FTY720 Update

Interesting update on FTY720 and their speculation that that it could be available for organ transplant patients -- and therefore also available for off-label use -- by 2007. Also the official results of their phase II trial are being released tomorrow.

Novartis Is Seeking to Beat Serono to First MS Pill

June 20 -- Bloomberg -- Serono, Europe's biggest biotechnology company, Novartis AG, Switzerland's largest drugmaker, and Paris-based Sanofi-Aventis SA are racing to develop the ...
Read more : FTY720 Update | Views : 3169 | Replies : 6

Allon Therapeutics

AL-108 is being tested on Alzheimer's first, but they plan to try it for MS too, so I figure these Phase I safety studies won't have to be done all over again for MS since they are done on healthy adults.

Allon Therapeutics product AL-108 successful in Phase Ia clinical trial

June 15 -- CNW -- Allon Therapeutics, The Neuro Protection Company(TM), announced today that a Phase Ia human clinical trial of the company's first ...
Read more : Allon Therapeutics | Views : 1162 | Replies : 0

Snail toxin

This isn't even in clinical trials, but it sounds promising -- treats neuropathic pain AND accelerates recovery from nerve injury...I hear rumours that it might bring about world peace too...

Snail toxin may help neuropathic pain

June 10 -- UPI -- Melbourne researchers' discovery of a cone snail toxin may help ease pain for neuropathic pain associated with diabetes.

Metabolic Pharmaceuticals Limited says successful results in preclinical trials of the toxin will result in clinical ...
Read more : Snail toxin | Views : 1515 | Replies : 1


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