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Studies on the genetics of MS

Genetics studies provide new clues to why people develop MS
06 March 2009

New studies are deciphering the complex picture of genetic characteristics that make people susceptible to MS, thanks to international collaborations and unique population studies. Each gives important new clues about why people get MS. Additional large-scale studies, the first stages of which are already underway, promise to uncover the great majority of genes that convey risk for MS, which would pave ...
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Gene Therapy in RA

Two people received genetherapy (IL-1) for RA with some encouraging results: ... 153941.htm

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iCBBE2009 international conference call for paper xm

We apologize if you receive multiple copies of this message
The 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE2009)
Beijing, China June 11-13, 2009
This conference is sponsored by IEEE Engineering in Medicine and Biology Society (EMBS),
Beijing Institute of Technology and Wuhan University. All the papers accepted will be included
in the IEEE Xplore and indexed by EI. For more information, ...
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"Roquin" Gene, and its relation to AI conditions

Saw a program on TV about it, and found this on the web site.

For the intro video

Her story details

And the MS bit
Research projects in Vinuesa’s group
Elucidating the role of the autoimmune modulator Roquin and TFH cells in the prevention of Experimental autoimmune encephalomyelitis: D. Silva, Joseph Ng, C. Vinuesa.
While mice with dysfunctional Roquin develop autoimmune diseases including diabetes, they are protected against experimental autoimmune encephalitis (EAE), a mouse model of ...
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Therapy Yields Promise for Fatal Neurological Condition

In a clinical trial, reported on in the May 13 online issue of Human Gene Therapy, neurological surgeons created six tiny holes in the skull of a patient, and then injected into the brain a liquid containing the healthy CLN2 gene within the harmless adeno-associated virus (AAV).

"The virus is used as a Trojan horse that houses and then delivers a healthy, functional gene into the cells of the brain," Crystal said. "The genes ...
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The crucial role of calcium ion channels...

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"Since mast cells are also known to contribute to the progression of several other debilitating diseases, including multiple sclerosis, rheumatoid arthritis and cancer, an inhibitor of the CRAC channel could, in the future, help in slowing the progression of these diseases as well as alleviate disease symptoms."
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Surprise in Lab Helps ID Drug to Fight ALS

Not sure if this falls under gene therapy really, but seemed as good as place as any.

"It is exciting not only from the standpoint of ALS, but also because of its implications for understanding basic cell biology. Rac1 is implicated in many cellular processes including cellular migration, proliferation and differentiation, and is an important component of inflammatory disease processes," team leader John Engelhardt, head of anatomy and cell biology at UI's Roy J. ...
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gene therapy without viruses

Sounds promising for all types of gene therapy, no specific mention of MS.

Gene Therapy without Viruses: A new, highly effective polymer may make gene therapy safer.

Katherine Bourzac - Technology Review - The promise of gene therapy has long been held up by the lack of a safe and effective way to insert the desired therapeutic genes into the right cells. To solve that problem, MIT researchers have developed a new polymer for gene ...
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