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"Roquin" Gene, and its relation to AI conditions

Saw a program on TV about it, and found this on the web site.

For the intro video

Her story details

And the MS bit
Research projects in Vinuesa’s group
Elucidating the role of the autoimmune modulator Roquin and TFH cells in the prevention of Experimental autoimmune encephalomyelitis: D. Silva, Joseph Ng, C. Vinuesa.
While mice with dysfunctional Roquin develop autoimmune diseases including diabetes, they are protected against experimental autoimmune encephalitis (EAE), a mouse model of ...
Read more : "Roquin" Gene, and its relation to AI conditions | Views : 2355 | Replies : 0


Therapy Yields Promise for Fatal Neurological Condition

http://www.washingtonpost.com/wp-dyn/content/article/2008/05/13/AR2008051301592.html

In a clinical trial, reported on in the May 13 online issue of Human Gene Therapy, neurological surgeons created six tiny holes in the skull of a patient, and then injected into the brain a liquid containing the healthy CLN2 gene within the harmless adeno-associated virus (AAV).

"The virus is used as a Trojan horse that houses and then delivers a healthy, functional gene into the cells of the brain," Crystal said. "The genes ...
Read more : Therapy Yields Promise for Fatal Neurological Condition | Views : 2570 | Replies : 0




The crucial role of calcium ion channels...

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"Since mast cells are also known to contribute to the progression of several other debilitating diseases, including multiple sclerosis, rheumatoid arthritis and cancer, an inhibitor of the CRAC channel could, in the future, help in slowing the progression of these diseases as well as alleviate disease symptoms."
Read more : The crucial role of calcium ion channels... | Views : 2966 | Replies : 1


Surprise in Lab Helps ID Drug to Fight ALS

Not sure if this falls under gene therapy really, but seemed as good as place as any.

http://www.washingtonpost.com/wp-dyn/content/article/2008/01/24/AR2008012402485.html


"It is exciting not only from the standpoint of ALS, but also because of its implications for understanding basic cell biology. Rac1 is implicated in many cellular processes including cellular migration, proliferation and differentiation, and is an important component of inflammatory disease processes," team leader John Engelhardt, head of anatomy and cell biology at UI's Roy J. ...
Read more : Surprise in Lab Helps ID Drug to Fight ALS | Views : 2670 | Replies : 0


gene therapy without viruses

Sounds promising for all types of gene therapy, no specific mention of MS.



Gene Therapy without Viruses: A new, highly effective polymer may make gene therapy safer.

Katherine Bourzac - Technology Review - The promise of gene therapy has long been held up by the lack of a safe and effective way to insert the desired therapeutic genes into the right cells. To solve that problem, MIT researchers have developed a new polymer for gene ...
Read more : gene therapy without viruses | Views : 2932 | Replies : 0


gene therapy without viruses

Sounds promising for all types of gene therapy, no specific mention of MS.



Gene Therapy without Viruses: A new, highly effective polymer may make gene therapy safer.

Katherine Bourzac - Technology Review - The promise of gene therapy has long been held up by the lack of a safe and effective way to insert the desired therapeutic genes into the right cells. To solve that problem, MIT researchers have developed a new polymer for gene ...
Read more : gene therapy without viruses | Views : 2650 | Replies : 0


Gene therapy for Parkinsons

Not MS, but another interesting research area which could be relevant in future.

http://www.timesonline.co.uk/tol/life_a ... 969240.ece
Read more : Gene therapy for Parkinsons | Views : 3148 | Replies : 1


Gene research

Interesting article about research to better understand the genes involved in various diseases. I read elsewhere that the team is also looking at MS and are to report at the end of this year.

Ian

http://news.bbc.co.uk/1/hi/health/6724369.stm
Read more : Gene research | Views : 2739 | Replies : 0




 

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