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A new mouse model for Multiple Sclerosis fatigue?

Researchers presented a new mouse model for fatigue at the 2014 Society for Neuroscience meeting. The model is the first of its kind and works by manipulating the pro-inflammatory cytokine interleukin-1β.

There’s a new animal model coming down the pike that may be of use to multiple sclerosis researchers. At the Society for Neuroscience (SfN) annual meeting in Washington, D.C., researchers announced that they have developed a new mouse model for fatigue. This is the ...
Read more : A new mouse model for Multiple Sclerosis fatigue? | Views : 170 | Replies : 1


Could alcohol reduce the risk of getting MS?

A study by Dr. Anna Karin Hedström and a team of researchers from Sweden's Karolinska Intstitute have discovered a possible link between alcohol consumption and a reduction in the risk of having multiple sclerosis, the degenerative disease of the central nervous system.

According to the abstract of the study published in the Journal of the American Medical Association, the researchers' goal was to “investigate the possible association of alcohol consumption with the risk of developing ...
Read more : Could alcohol reduce the risk of getting MS? | Views : 135 | Replies : 0


Remyelination: new research from Karolinska Institute

New research from the Karolinska Institute shows us, once again, that human and mouse brains are not the same. Past assumptions about remyelination have been incorrect. Attempting to understand remyelination in the human brain using a mouse model simply does not work.

But there are things humans can do to remyelinate their own brains---and it's all about using the brain, and plasticity.

Here's the new research, which is calling into question all MS specialists thought ...
Read more : Remyelination: new research from Karolinska Institute | Views : 636 | Replies : 18


Tongue shocks hasten healing

A little-known fact: the tongue is directly connected to the brain stem. This anatomical feature is now being harnessed by scientists to improve rehabilitation.

A team at the University of Wisconsin–Madison recently found that electrically stimulating the tongue can help patients with multiple sclerosis (MS) improve their gait. MS is an incurable disease in which the insulation around the nerves becomes damaged, disrupting the communication between body and brain. One symptom is loss of muscle ...
Read more : Tongue shocks hasten healing | Views : 133 | Replies : 0


Clinical focus in MS: Novel approaches to progressive MS

Clinical focus in MS: Novel approaches to progressive disease

Although the drug development pipeline still contains numerous products intended for patients with relapsing-remitting multiple sclerosis (RRMS), the consensus among clinicians is that relapses can be effectively squelched in nearly all RRMS patients with the dozen or so currently approved therapies.

Patients now have a choice between injectables and oral drugs, and within the injectable class there is a range of dosing intervals and delivery types ...
Read more : Clinical focus in MS: Novel approaches to progressive MS | Views : 104 | Replies : 0


What's the verdict on coffee?

I was recently diagnosed with acid reflux disease (pile it on!). Coffee really appears to be the biggest inflammatory agent in my gut, although unfortunately beer and spicy foods are some of my favorite things and those are also naughty. There are a lot considerations I'm making regarding my finicky gut and possible ties to MS progression, but that's just a side note.

I get up at 6:30 AM so a cup of coffee is ...
Read more : What's the verdict on coffee? | Views : 359 | Replies : 10


impotence

Question for the men, this is definitly an awkward topic but I've recently been have issues with impotence. Just wondering if anyone else has or is experiencing this as a symptom of MS and if anything has helped?
Read more : impotence | Views : 395 | Replies : 16


Could NDC-1308 be a new hope for secondary progressive MS?

ENDECE Neural announced the presentation of new, pre-clinical evidence that the company’s lead compound, NDC-1308, induces remyelination and increases forelimb grip strength in a validated animal model of demyelination. As presented in a poster session at the 2014 annual meeting of the Society for Neuroscience in Washington, D.C., the improvements with NDC-1308 therapy are linked to the drug’s unique ability to repair the myelin sheath of demyelinated axons (nerve fibres).

The data, presented by Steven ...
Read more : Could NDC-1308 be a new hope for secondary progressive MS? | Views : 177 | Replies : 0


Azathioprine versus beta interferons for RRMS

Azathioprine versus Beta Interferons for Relapsing-Remitting Multiple Sclerosis: A Multicentre Randomized Non-Inferiority Trial

Luca Massacesi, Irene Tramacere, Salvatore Amoroso, Mario A. Battaglia, Maria Donata Benedetti, Graziella Filippini, Loredana La Mantia, Anna Repice, Alessandra Solari, Gioacchino Tedeschi, Clara Milanese

Abstact

For almost three decades in many countries azathioprine has been used to treat relapsing-remitting multiple sclerosis. However its efficacy was usually considered marginal and following approval of β interferons for this indication it was no longer ...
Read more : Azathioprine versus beta interferons for RRMS | Views : 135 | Replies : 0


Limbspasm treatments for MS patients explored by 2 companies

Limb spasm treatments for MS patients explored by two companies

Upper limb spasticity and lower leg cramps and spasms, two conditions that affect patients with multiple sclerosis, are being treated in separate clinical trials with results from both showing positive benefits. Dysport (abobotulinumtoxinA), from Ipsen Biopharmaceuticals, Inc., and transient receptor potential (TRP) activators, from Flex Pharma, are proving to be effective in alleviating patients’ symptoms in novel ways..... Read More - http://www.ms-uk.org/mssymptomsresearch
Read more : Limbspasm treatments for MS patients explored by 2 companies | Views : 177 | Replies : 0


 

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