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To boost or supress autoimmunity, that is the question

Breaking peripheral immune tolerance to CNS antigens in neurodegenerative diseases: Boosting autoimmunity to fight-off chronic neuroinflammation.

Schwartz M, Baruch K.

Abstract

Immune cell infiltration to the brain's territory was considered for decades to reflect a pathological process in which immune cells attack the central nervous system (CNS); such a process is observed in the inflammatory autoimmune disease, multiple sclerosis (MS).

As neuroinflammatory processes within the CNS parenchyma are also common to other CNS pathologies, regardless ...
Read more : To boost or supress autoimmunity, that is the question | Views : 186 | Replies : 1


People with multiple sclerosis lose myelin in grey matter

People with multiple sclerosis (MS) lose myelin in the grey matter of their brains and the loss is closely correlated with the severity of the disease, according to a new magnetic resonance imaging (MRI) study. Researchers said the findings could have important applications in clinical trials and treatment monitoring. The study appears online in the journal Radiology.

Loss of myelin, the fatty protective sheath around nerve fibres, is a characteristic of MS, an inflammatory disease ...
Read more : People with multiple sclerosis lose myelin in grey matter | Views : 213 | Replies : 2


New international MS survey results published

New International Survey Finds MS Patients and Neurologists View Communication Positively, Yet Struggle to Discuss Key MS Symptoms.

– Neurologists Underestimate Patient Discomfort with Discussing More Typical Symptoms
– Patients Most Uncomfortable Engaging in Candid Dialogue about More Private Symptoms
– Patients and Physicians Not Always Aligned........ Read More - http://www.ms-uk.org/qol
Read more : New international MS survey results published | Views : 127 | Replies : 0


Visual system as a predictor of change from CIS to MS

Evaluation of visual structural and functional factors that predict the development of multiple sclerosis in clinically isolated syndrome patients.

Perez-Rico C, Ayuso-Peralta L, Rubio-Pérez L, Roldán-Díaz I, Arévalo-Serrano J, Jiménez Jurado D, Blanco R.

Abstract

PURPOSE. To evaluate visual pathway structure and function in patients with clinical isolated syndrome (CIS) using spectral domain optical coherence tomography (OCT) and multifocal visual evoked potentials (mfVEP), predicting CIS conversion to clinically definite multiple sclerosis (MS).

METHODS. This observational, ...
Read more : Visual system as a predictor of change from CIS to MS | Views : 129 | Replies : 0


MS researchers find role for working memory in cognitive....

MS researchers find role for working memory in cognitive reserve

Kessler Foundation scientists have shown that working memory may be an underlying mechanism of cognitive reserve in multiple sclerosis (MS).

This finding informs the relationships between working memory, intellectual enrichment (the proxy measure for cognitive reserve) and long-term memory in this population..... Read More - http://www.ms-uk.org/cognition
Read more : MS researchers find role for working memory in cognitive.... | Views : 116 | Replies : 0


New Website to Review Disabled Accessibility

Hi:

I'm Nancy (diagnosed RRMS in 2008). After a series of relapses became dependent on a walker and scooter.

I recently launched a new site that enables contributors to review disabled accessibility of the places they go.

http://www.disabledonthego.com

Please come, join the community and post reviews. Your participation would help everyone in the MS community who uses mobility assistance aids (and other disabled persons as well)!

Nancy@disabledonthego.com
Read more : New Website to Review Disabled Accessibility | Views : 130 | Replies : 0


Could Dock3 protect against demyelination?

Dock3 protects myelin in the cuprizone model for demyelination.

Namekata K, Kimura A, Harada C, Yoshida H, Matsumoto Y, Harada T.

Abstract

Dedicator of cytokinesis 3 (Dock3) belongs to an atypical family of the guanine nucleotide exchange factors. It is predominantly expressed in the neural tissues and causes cellular morphological changes by activating the small GTPase Rac1.

We previously reported that Dock3 overexpression protects retinal ganglion cells from excitotoxic cell death. Oligodendrocytes are the myelinating ...
Read more : Could Dock3 protect against demyelination? | Views : 204 | Replies : 1


Body aches

I am fairly new to ms only being diagnosed in May this year and for the last month have been waking up with body aches all over in particular my legs. Most days lately I've been sleeping for a good 12 hrs a day and after only being awake a couple of hours I feel the need to go back to sleep. I just feel awful every day, tired aching and kind of weak. Has ...
Read more : Body aches | Views : 235 | Replies : 8


Comorbidities appear more prevalent in people with MS

While multiple sclerosis is most typically associated with progressively declining physical ability, multiple sclerosis patients are often times affected by a number of physical and mental health comorbidities in addition to their worsening physical ability. This observation was highlighted by a group of researchers in Scotland led by Drs. Robert J. Simpson and Stewart W. Mercer of the University of Glasgow...... Read More - http://www.ms-uk.org/qol
Read more : Comorbidities appear more prevalent in people with MS | Views : 198 | Replies : 0


The clincial meaning of 'Walking Speed'

The Clinical Meaning of Walking Speed as Measured by the Timed 25-Foot Walk in Patients With Multiple Sclerosis.

Cohen JA, Krishnan AV, Goodman AD, Potts J, Wang P, Havrdova E, Polman C, Rudick RA.

Abstract

IMPORTANCE: Walking impairment, a common clinical manifestation of multiple sclerosis (MS), is often measured in clinical practice and clinical trials using the Timed 25-Foot Walk (T25-FW).

OBJECTIVE: To evaluate the relationship between walking speed measured by the T25-FW and the ...
Read more : The clincial meaning of 'Walking Speed' | Views : 193 | Replies : 0


 

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