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Pathological mechanisms in progressive multiple sclerosis

Summary
A better understanding of the pathological mechanisms that drive neurodegeneration in individuals with multiple sclerosis is needed to develop therapies that will effectively treat patients in the primary and secondary progressive stages of the disease. We propose that the inflammatory demyelinating disease process in early multiple sclerosis triggers a cascade of events that lead to neurodegeneration and are amplified by pathogenic mechanisms related to brain ageing and accumulated disease burden. Key elements driving neurodegeneration ...
Read more : Pathological mechanisms in progressive multiple sclerosis | Views : 277 | Replies : 0


New chemical entity for optic neuritis and MS in development

Bionure, Inc. a California-based late-preclinical drug development company, today announced that it has entered into a Sponsored Research Agreement with the US National Multiple Sclerosis Society through Fast Forward, its commercial research subsidiary aimed at accelerating the development of new and improved therapies for MS. Under this agreement, Fast Forward will provide funding to Bionure for the late-preclinical development of BN201 to enable IND filling to support the Phase 1 clinical study in Acute Optic ...
Read more : New chemical entity for optic neuritis and MS in development | Views : 241 | Replies : 0


Inclined Bed Warning

On November 29, 2014 I published a blog entry titled “Progressive MS and the Spine” on this site. I entered the same post on Thisisms.com the same day. In response Stillhaha wrote

“Thanks for posting this.
Personally, I keep finding excuses (foolish, impractical ones) to avoid trying Inclined Bed Therapy for my PPMS. Your post makes me think about CSF and if I can repair things.”

I decided to try an Inclined Bed as well, ...
Read more : Inclined Bed Warning | Views : 357 | Replies : 1


Collaboration aims to reduce neurodegeneration in MS

University of Edinburgh and Genzyme collaboration aims to reduce neurodegeneration in MS

University of Edinburgh scientists are set to work with leading biotechnology company Genzyme, a Sanofi company, to carry out drug discovery research that could reduce neuron damage in the brain.

The collaboration - facilitated by Edinburgh BioQuarter's Business Development team - will focus on identifying therapeutic candidates capable of promoting remyelination and reducing neurodegeneration, mostly in relation to Multiple Sclerosis (MS)............ Read More ...
Read more : Collaboration aims to reduce neurodegeneration in MS | Views : 290 | Replies : 0


Not about MS, but some might find interesting

Wouldn't it be great if some of these geniuses would figure out a panel board to reroute and override a damaged nervous system or spine with a new one.

https://www.youtube.com/embed/9J7GpVQCfms
Read more : Not about MS, but some might find interesting | Views : 320 | Replies : 1


FlopStops

I am not selling anything. I am genuinely looking for information. Has anyone ever tried FlopStops footwear, for foot drop. They have testimonials by pwMS on their web site but I am skeptical. It looks like a band around the back of the heel with bungies connected to the top of the shoe, at the instep. this would pull the shoe up, and I guess your weight would pull it back down.

I have thought ...
Read more : FlopStops | Views : 247 | Replies : 1


Lifestyle factors contribute to depression in MS patients

Lifestyle factors contribute to depression in patients with MS

Modifiable lifestyle factors contribute to depression in multiple sclerosis (MS) patients, according to a study published in BMC Psychiatry.

Researchers from St. Vincent's Hospital Melbourne in Victoria, Australia examined nearly 2,500 MS patients in order to understand the association between lifestyle risk factors, medication, and depression risk through the analysis of self reported data. The researchers collected data about the participants' sociodemographics, diagnostic history, level of ...
Read more : Lifestyle factors contribute to depression in MS patients | Views : 324 | Replies : 2


HPV vaccination not associated with increased risk of MS

HPV vaccination not associated with increased risk of Multiple Sclerosis

Although some reports have suggested a link between human papillomavirus (HPV) vaccination and development of multiple sclerosis or other demyelinating diseases (a group of central nervous system disorders), a follow-up of girls and women in Denmark and Sweden who received this vaccination found no increased risk for these disorders, according to a study in the January 6 issue of JAMA..... Read More - http://www.ms-uk.org/vaccinations
Read more : HPV vaccination not associated with increased risk of MS | Views : 205 | Replies : 0




I want to hear about your MS Canadian experience ($$)

Hi,

I'm looking for Canadian MS patients to share their experience of dealing with the disease, treatment, patient programs, etc. Participation is done over the phone and paid right after your participation.

Please contact me if you are interested (you must currently be on treatment prescribed by physician).

Looking forward to hearing from you.

Marianne

Marianne.fillion@gmail.com
Read more : I want to hear about your MS Canadian experience ($$) | Views : 275 | Replies : 0


 

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