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Staring into the void: Black holes and MS prognosis

Physicians commonly measure multiple sclerosis (MS) disease activity based on the appearance of new T2-weighted hyperintense MRI lesions, which arise due to edema, inflammation, gliosis, and axonal loss. Given the nonspecific disease processes leading to these lesions and the often-mediocre correlation between T2 lesions and clinical outcomes, however, the search continues for a more specific tool that lends insight into MS pathophysiology and disease activity.

In recent years, increasing attention has been paid to the ...
Read more : Staring into the void: Black holes and MS prognosis | Views : 391 | Replies : 1


Blood test to clasify patients?

Source: http://www.sciencedirect.com/science/ar ... 1614000515


Identification of a B cell-dependent subpopulation of multiple sclerosis by measurements of brain-reactive B cells in the blood

Highlights

•CNS-reactive B cells can be detected in the blood of CIS/MS patients by ELISPOT.
•CNS-reactive B cells are absent in healthy control subjects.
•CNS-reactive B cells are absent in neurological and autoimmune control subjects.
•CNS-reactive B cells in the blood possibly indicate B cell-dependent MS.

Abstract ...
Read more : Blood test to clasify patients? | Views : 367 | Replies : 1


MS healing dream

After the Neurologist gave me the MS verdict in December 1981 I had the following dream. I had been running down a track when I was forced off to the side, I couldn’t keep up. After watching the roaring crowd race by, my body sank deep into the warm moist earth, curling up into a hard round tulip bulb. I would wait hidden until spring.

And spring did come. After a year of detoxification and ...
Read more : MS healing dream | Views : 355 | Replies : 0


MS drug MIS416 benefits from compassionate use...

Multiple sclerosis drug MIS416 benefits from compassionate use in progressive MS

Innate Immunotherapeutics drug candidate for secondary progressive multiple sclerosis continues to benefit patients being treated on compassionate grounds in New Zealand.

It is also providing the company with strong data and results from use of MIS416 which show the majority of patients in the program are benefitting from its use.

Of the 24 patients using drug candidate MIS416, 15 were previously subjects in the ...
Read more : MS drug MIS416 benefits from compassionate use... | Views : 418 | Replies : 1


Myelin repair in mice enhanced .....

Myelin repair in mice enhanced using stem cells and other novel approaches

Two teams of researchers report success in stimulating the repair of nerve-insulating myelin in mouse models of MS. Myelin is a major target of immune attacks in MS, and although these are early results and further work is needed, these findings show some promise for strategies to repair damage and restore function for people with multiple sclerosis......... Read More - http://www.ms-uk.org/myelin
Read more : Myelin repair in mice enhanced ..... | Views : 375 | Replies : 1


iPad performance testing in MS

In the not-too-distant future, patients with multiple sclerosis (MS) may simply strap on an iPad to complete their balance and walking tests, without the need for a technician.

The test results would be automatically uploaded to a clinical or research database, eliminating the chance of human error.

And patients may be doing the tests in the comfort of their own home, eliminating the need to visit a clinic, a boon to those living in rural ...
Read more : iPad performance testing in MS | Views : 317 | Replies : 1


Could brain imaging help treat MS-related depression?

Magnetic resonance imaging (MRI) can predict responses to depression treatment in patients with multiple sclerosis (MS), according to Anthony Feinstein, Professor at the Department of Psychiatry of the Sunnybrook Health Sciences Centre & the University of Toronto. In the presentation “Depression in MS: Is brain imaging helpful?” at this year’s 2014 CMSC ACTRIMS Annual Meeting in Dallas, the researcher argued that continuing to image and document brain function will help in the diagnosis and treatment ...
Read more : Could brain imaging help treat MS-related depression? | Views : 278 | Replies : 0


Oceans of Hope sets sail on circumnavigation for MS

The Danish yacht, Oceans of Hope, has set sail from Copenhagen on a historic global voyage. It is the first ever circumnavigation of the world by a yacht crewed by people with multiple sclerosis (MS)..... Read More - http://www.ms-uk.org/MSnews
Read more : Oceans of Hope sets sail on circumnavigation for MS | Views : 290 | Replies : 0


Positive top-line results in phase III Daclizumab high-Yield

Positive top-line results in phase III Daclizumab high-Yield process study in MS

Biogen Idec and AbbVie ABBV announced positive top-line results from the Phase 3 DECIDE clinical trial, designed to evaluate the superiority of once-monthly, subcutaneous daclizumab high-yield process (DAC HYP) when compared to intramuscular interferon beta-1a (IFN β-1a), as a potential treatment for relapsing-remitting multiple sclerosis (RRMS), the most common form of multiple sclerosis (MS). Results showed that DAC HYP was superior on the ...
Read more : Positive top-line results in phase III Daclizumab high-Yield | Views : 447 | Replies : 1


Is it time to rethink the MS immune cell theory?

Rituximab Efficiently Depletes Increased CD20-Expressing T Cells in Multiple Sclerosis Patients.

Palanichamy A, Jahn S, Nickles D, Derstine M, Abounasr A, Hauser SL, Baranzini SE, Leppert D, von Büdingen HC.

Abstract

In multiple sclerosis (MS), B cell-depleting therapy using monoclonal anti-CD20 Abs, including rituximab (RTX) and ocrelizumab, effectively reduces disease activity.

Based on indirect evidence, it is generally believed that elimination of the Ag-presenting capabilities and Ag nonspecific immune functions of B cells underlie the ...
Read more : Is it time to rethink the MS immune cell theory? | Views : 514 | Replies : 0


 

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