This Is MS Multiple Sclerosis Community: Knowledge & Support

If you can get through all the numbers and jargon in this abstract, I think it says that there is a small amount of BBB leakage in non-active lesions, and that natalizumab does nothing to stop this.

LeakyBBB
Dom.

PS Special clue for you, Bob: try clicking on the words 'leakyBBB' :D

Somewhat promising link regarding Lipoic Acid:

Lipoic acid stimulates cAMP production in T lymphocytes and NK cells.
Biochem Biophys Res Commun. 2007 Mar 2;354(1):259-64.

Here's a question for people from the UK,
Having to update a paper License, we find there is a clause where you have to mention if you have an illness which could progress to your inability to drive. How many people have let the DVLA know they are ill, is the information safe from anyone besides them finding out, and does telling them mean you have to have a driving test again?
Thanks for any ...

hi folks,

when i went through my diagnostics with my neuros (there was more then one), my CSF was negative for the oligoclonal bands...i have since read articles stating that around 10-15% of people positive for MS have this result with their CSF studies...i don't know if this is an old topic or not, but i was just wondering if anyone else also had a negative CSF...and, if so, if anyone has any info on ...

I wanted to share that interesting article i just came across:

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Greets

--Frank

http://www.eurekalert.org/pub_releases/2007-02/ul-spn022207.php

http://www.eurekalert.org/pub_releases/2007-02/esf-lfs022207.php

I'll post this under 'stem cells', but thought it would maybe reach more people here.
Dom

Hi
I have been sent for tests to find out why I keep having miscarriages. I know Hughes syndrome is a nice outcome to get if you've MS, but sadly I have tested negative for Hughes, and thankfully, negative for Lupus.
But I have been told today I have another clotting disorder, but I'll find out which one on tues (dontcha love the medical profession!)
My head is in a whirl... ...

URLPubmed

I take Inosine, and think it helps, but have to buy it from the U.S.,(expensive). Anyone found it in the U.K.? "RhosT" on 'ms news' points out that it is also commonly used as an anti-herpes drug, and HHV often crops up in relation to MS.

Dom.

This may be old news to some, but its new to me. I had thought mino only worked due to its ant-inflamatory properties, but it also appears to reduce the BBB disruptions.

Minocycline Improves Neurological Outcome and Reduces BBB Disruption, Hemorrhage, and Perivascular Microglial Accumulation In Vivo

http://stroke.ahajournals.org/cgi/content/full/37/4/1087

A second agent that acts at the BBB is minocycline. Matrix metalloproteinases (MMPs) are produced during inflammation and contribute to the degradation of the basement membrane. This step ...

Just saw on the Canadian Global TV News network this evening an article about Prolactin and its apparent effect on pregnant MS patients.

These women produce Prolactin during pregnancy and they discovered that Prolactin rebuilds myelin in the brain lesions of the poor MS mouse. The researchers are likely going to spend two more years testing this on other animals and then depending what they discover, try it on humans.

Here is the link.

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