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IL-17 role in MS further clarified

Looks as though we all owe interferon-gamma a bit of an apology...and IL-17 is coming right off my Christmas card list...



IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis.

J Immunol. 2006 Jul 1;177(1):566-73.
Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, Kakuta S, Sudo K, Iwakura Y.
Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

IL-17 is a proinflammatory cytokine that activates T ...
Read more : IL-17 role in MS further clarified | Views : 876 | Replies : 0


Paralysed rat

Normally I would put this under stem cells but an interesting read. Interesting that they may trial on pigs before humans. You'd think they could come up with a pig model of MS. As usual the good times are five years away - but a little bit of progress is better than none.

http://c.moreover.com/click/here.pl?j562399231&w=464753
Read more : Paralysed rat | Views : 841 | Replies : 0


depression

can anyone let me know if they take anything that helps there mood. i am going to my neuro this week and need some help. i feel like i am falling into a hole. there does'nt seem to be anything to help the ms so at least i hope there is something to brighten my mood. if there is a drug that you feel really helps i would much appreciate the name of the it ...
Read more : depression | Views : 2446 | Replies : 16


when does an attack 'end'?

hey all.

so my attack started on january 23rd/24th, and got worse and worse until january 29th. then the long slow climb back started.

here we are june 19, and although i have seen TONS of progress, the curve has really started to flatten out. so how do you know when the attack "ends"? can attacks be months or even a year long?

if this is me 'between attacks', i think it's starting to make ...
Read more : when does an attack 'end'? | Views : 1656 | Replies : 9


(Others) Thoughts on different MS (RR & SP)

The following link had the following explanation, which i personally hadnt read before, and it made sense to me for the progression from RR to SP. dont know if it is still scientifically valid (if it ever was....)
The authors, Prof Compston and Coles of Cambridge, UK, concluded that axons were withering (transecting) due to a loss of trophic support from oligodendrocytes even in the absence of inflammation. ‘Trophic support’ describes the process whereby oligodendrocytes ...
Read more : (Others) Thoughts on different MS (RR & SP) | Views : 1193 | Replies : 3


Measuring re-myelination

If they ever figure out how to encourage re-myelination, they will need ways of measuring it.

Some progress being made on the measuring side:

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Ian
Read more : Measuring re-myelination | Views : 873 | Replies : 0


Currently going through stem cell transplant

Hello everyone, I am currently in the middle of my stem cell transplant for MS in Ottowa Canada. I currently have a hickman line attached and have been through the first cemo sessions along with the Neupagen shots for my collection. I am currently waiting for my final cemo and the reinsertion of my stem cells which will start in July. My strenghth is almost at my baseline again and I will try to respond ...
Read more : Currently going through stem cell transplant | Views : 1433 | Replies : 5


Guiding growing nerves.

More from 'Eurekalert!', though not strictly about MS. So, when you've grown yourself a brand, spanking new nervous system from stem cells, how do you connect it up? FGFs may help, although I think this may be more about peripheral rather than central nerves, it does mention spinal cord injury.



Public release date: 15-Jun-2006


New roles for growth factors: Enticing nerve cells to muscles
La Jolla, CA - During embryonic development, nerve cells hesitantly extend ...
Read more : Guiding growing nerves. | Views : 837 | Replies : 0


Number of lesions

Someone asked about the number of lesions and the correlation with disability. Here is an answer from the Canada MS site.

http://www.msanswers.ca/QuestionView.aspx?L=2&QID=240

Dr Myles looks a bit scary!

New technologies will allow the damage to neurons and axons to be measured which should provide a more accurate prognosis. My difficulty is - what if the scans suggest that you will become very severely disabled? What's the point of knowing ...
Read more : Number of lesions | Views : 1197 | Replies : 3


Skin, stem cells, and nerves.

Found this on 'Eurekalert!'. Sounds incredible that skin stem cells can become CNS tissue, (no ethical issues or rejection problems if they use your own skin),but here's hoping....


Public release date: 14-Jun-2006


Contact: Chelsea Gay
chelsea.gay@sickkids.ca
416-813-5045
University of Toronto

Stem cells found in adult skin can be transplanted and function in mouse models of disease
SickKids researchers behind new ...
Read more : Skin, stem cells, and nerves. | Views : 947 | Replies : 1


 

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