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New DNA findings

Interesting step on the road to understanding the genome.

The Wider View from a Detailed Focus

Sanger Institute Press Release -- A major study of the organization and regulation of the human genome published today changes our concept of how our genome works. The integrated study is an exhaustive analysis of 1% of the genome that, for the first time, gives an extensive view of genetic activity alongside the cellular machinery that allows DNA to ...
Read more : New DNA findings | Views : 934 | Replies : 0

Protein research

Prof Steinman is presenting at the MS Frontiers conference in London this week so may provide more detail on this research.

Stanford researchers clarify protein's role in multiple sclerosis 13 June 2007

A protein found primarily in the lens of the eye could be the critical "tipping point" in the spiral of inflammation and damage that occurs in multiple sclerosis, researchers at the Stanford University School of Medicine report.
This protein - alphaB-crystallin - ...
Read more : Protein research | Views : 958 | Replies : 2

Cladribine - one for Lyon


Now that you have ditched that dreadful shiny shirt and have signed up to the hair-transplant, I thought I'd reward you the research results you like to see.

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Read more : Cladribine - one for Lyon | Views : 1163 | Replies : 1

Histamine research

Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS. 13 June 2007

Histamine (HA), a biogenic amine with a broad spectrum of activities in both physiological and pathological settings, plays a key regulatory role in experimental allergic encephalomyelitis, the autoimmune model of multiple sclerosis. HA exerts its effect through four G protein-coupled receptors designated HA receptor H1, H2, H3, and H4.
We report here that, compared with wild-type ...
Read more : Histamine research | Views : 2792 | Replies : 20

Emotions gone this relapse?

I'm usually v. good at knowing what's a relapse and what's not - after 9 + years with the MonSter I should be!.

I seem to be crying at very small things. In work this has happened a few times recently. Feel very "teary" today and feel like I am raw emotionally. I know a lot's going on for me and DH right now (I am off Copax last 2 months as trying for ...
Read more : Emotions gone this relapse? | Views : 2039 | Replies : 12

Hormone Study - understanding/translation problem


could someome please help me to understand the results of that study, I think I have problems with the translation:

Link PubMed

RESULTS: Serum testosterone was significantly lower in women with MS than in controls. The lowest levels were found in women with a greater number of gadolinium enhancing lesions. A positive correlation was observed between testosterone concentrations and both tissue damage on MRI and clinical disability.
In men, there was a positive ...
Read more : Hormone Study - understanding/translation problem | Views : 1522 | Replies : 8

Interview with Dr. Marcia Angell

Dr. Marcia Angell, senior lecturer at the Harvard Medical School and former editor of The New England Journal of Medicine and author of the book The Truth About The Drug Companies, How They Deceive Us And What To Do About It reviewed on ThisIsMS here, was recently interviewed on NPR's Radio Open Source. You can find a discussion about the interview here and listen to an MP3 recording of the interview here.

Read more : Interview with Dr. Marcia Angell | Views : 1333 | Replies : 1

Autoantibodies as predictors of disease:

I found this when going through "Autoimmunity Reviews" and, although not specific to MS, hopefully it is of interest.

Autoantibodies as predictors of disease: The clinical and experimental evidence

Nicola BizzaroCorresponding Author Contact Information, a, E-mail The Corresponding Author
aLaboratorio di Patologia Clinica, Ospedale Civile, via Morgagni, 18, 33028 Tolmezzo, Italy

Available online 30 January 2007.


Several studies have shown that autoimmune diseases are preceded by a long pre-clinical phase, and that many ...
Read more : Autoantibodies as predictors of disease: | Views : 1270 | Replies : 3


Okay, another new symptom has appeared and it is incredibily annoying. I have experienced what I now think is classified as vertigo. I originally described the feeling as "spacey" or the feeling you get with having had one too many glasses of wine without the benefit of having the wine! But I went to the mountains of North Carolina this past weekend and the feeling was much much more pronounced. So then I thought altitude ...
Read more : vertigo | Views : 1501 | Replies : 8

Lowering Insulin

Here is another article for you, lyndacarol. ... wsid=73284

Medical News Today
Hormone Found In Liver Helps To Induce Ketosis, The Unique Metabolic State Brought About By Low-Carbohydrate Diets
11 Jun 2007

Over the past several years, animal studies have shown that high-fat, low-carbohydrate "ketogenic" diets cause
demonstrable changes in metabolism and subsequent weight loss. Now, researchers at Beth Israel Deaconess Medical
Center (BIDMC) have identified a key ...
Read more : Lowering Insulin | Views : 1460 | Replies : 4


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