This Is MS Multiple Sclerosis Community: Knowledge & Support

Immune system 'brakes' found

Scientists say they have learnt how the body controls the machinery it uses to fight infections and foreign invaders.

The advance, published in the journal Nature, may one day help find ways to tackle unwanted immune reactions following transplant surgery.

The Johns Hopkins University researchers say a protein molecule called carabin may be the body's way of restraining its defences.

The US-based team describes it as a 'built-in timer' for ...

Depression and insomnia are 2 of the wonderful side effects of my MS. Last night i couldnt sleep, so i take a little ambien to get me down. . i get a good 8 (waking up once or twice) - ambien does give me a side effect of making me a little more grouchy and depressed (not as bad as if i didnt get any sleep - lesser of 2 evils). I need to shake ...

If you don’t like conspiracy theories or half baked ideas, you can stop reading now, its long. However, if you enjoy to pick the threads from a poorly made suit, read on, I welcome the exchange.

Two points to start with:
1. Now, PRECEED EVERY SENTENCE WITH A "MAYBE", "POSSIBLY" or finish it with a "?" (as appropriate)
2. Read point 1 again.

* The BBB is in simple terms, the walls of capillaries http://www.daviddarling.info/encyclopedia/B/blood-brain_barrier.html ...

Woah, a big document with lots of pages (80 in english then 80 in flamish ie dutch)
https://dare.ubvu.vu.nl/bitstream/1871/9249/1/Breij_dissertation.pdf

I havent read it yet (its long) but it looks really interesting.

Houdoe en bedankt.

It seems to me that Dr Kurtzke has done more than anyone in generating and compiling MS data and trying to arrange it in a way as to make sense of a historically nonsensible situation.

Even though this paper is dated (1993) and the data used is even more dated, it seems to me that anyone affected with MS should take the time to read this one, if for no better reason than to gain ...

The bright side of pollution... :lol:

http://www.newscientist.com/article/dn1 ... ptoms.html

--Frank

Interesting genetics of MS study. I expect Bromley might have something to say about this as I think part of his personal team of world-leading neurologists is involved...



A second major histocompatibility complex susceptibility locus for multiple sclerosis.

Ann Neurol. 2007 Jan 24;
Yeo TW, De Jager PL, Gregory SG, Barcellos LF, Walton A, Goris A, Fenoglio C, Ban M, Taylor CJ, Goodman RS, Walsh E, Wolfish CS, Horton R, Traherne ...

Antibodies to Myelin Don't Signal MS

By Neil Osterweil, Senior Associate Editor, MedPage Today
Reviewed by Rubeen K. Israni, M.D., Fellow, Renal-Electrolyte and Hypertension Division, University of Pennsylvania School of Medicine
January 24, 2007


Basel, Switzerland, Jan. 24 -- Contrary to a previous report, the presence in the blood of two types of antibodies to myelin is not diagnostic of multiple sclerosis, investigators here reported.

Nor does the presence of the antibodies indicate a risk ...

hello to all,

while i've posted a few comments, i've probably been more of an observer...i've read a lot of poignant and touching comments by many members and thought i would vent a little bit. i am a thirty-something year old guy who had one significnat attack about 2 years ago. i was pretty sick for about a year, but eventyually slowly recovered. these days, i've been pretty fortunate in that i only have a ...

Chopping Off Protein Puts Immune Cells Into High Gear


St. Jude study shows LAG-3 protein on activated T lymphocytes slows replication until ADAM10 and ADAM17 enzymes cleave it off to allow these cells to reproduce rapidly

MEMPHIS, Tenn., Jan. 24 /PRNewswire/ -- The complex task of launching a well-organized, effective immune system attack on specific targets is thrown into high gear when either of two specific enzymes chop a protein called LAG-3 off the immune ...