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Inflammation vs. neurodegeneration


as some of you might remember, after a serious disagreement on this board eighteen months ago, I got angry and removed all my messages. After reposting one of them few days ago, I checked them all to see if there was something else worth reposting. IMO, there was. As a member of "MS is not an autoimmune disease -camp" I'd like to share following two posts with you again.

The first post underlines the ...
Read more : Inflammation vs. neurodegeneration | Views : 48327 | Replies : 313

Blood tests

I have some questions for all of you experts about my latest blood test. The idiot intern doctor left a message on my machine that everything was fine. I got a copy today because I want to bring it to my neurologist to ask about Vit D levels. One of my liver enzymes-GOT/AST-was high. Not exceedingly, but high all the same. This kind of freaked me out as I'm supposed to do my shot tonight. ...
Read more : Blood tests | Views : 1241 | Replies : 2

Neuronal Damage in Brain Inflammation

Neuronal Damage in Brain Inflammation

Orhan Aktas, MD; Oliver Ullrich, MD; Carmen Infante-Duarte, PhD; Robert Nitsch, MD; Frauke Zipp, MD

Arch Neurol. 2007;64:185-189.


In contrast to traditional textbook paradigms, recent studies indicate neuronal damage in classic neuroinflammatory diseases of the brain, such as multiple sclerosis or meningitis. In these cases, immune cells invade the central nervous system compartments, accompanied by a massive breakdown of the blood-brain barrier and typical changes of the cerebrospinal fluid. ...
Read more : Neuronal Damage in Brain Inflammation | Views : 1193 | Replies : 0

Brain research

Another nice illustration of how much we're learning and how our understanding of the brain is evolving.

Brain works more chaotically than previously thought

March 1, 2007 - The brain appears to process information more chaotically than has long been assumed. This is demonstrated by a new study conducted by scientists at the University of Bonn. The passing on of information from neuron to neuron does not, they show, occur exclusively at the synapses, i.e. ...
Read more : Brain research | Views : 758 | Replies : 0

Calcium ions and the brain

Interesting research that could have MS implications.

Calcium is spark of life, kiss of death for nerve cells

March 1, 2007 -- Oregon Health & Science University research shows how calcium regulates the recharging of high-frequency auditory nerve cells after they've fired a burst of signals, and it may have implications for neurological disorders.

The study by scientists at OHSU's Vollum Institute and the University of Arkansas for Medical Sciences, which appears in the current ...
Read more : Calcium ions and the brain | Views : 1223 | Replies : 2


Enabling nerve regeneration means evicting the cleanup crew

Macrophages are the immune cells that engulf and destroy the debris of damaged tissue to enable the healing process to begin. Their presence at the scene of damage is critical, but once their task is complete, it is just as critical that macrophages exit rapidly, ending the inflammatory process and making way for regrowth. In fact, the continued presence of macrophages could damage tissue, compromising repair. ...
Read more : Nogo | Views : 1189 | Replies : 4

Google brain!

An interesting, but oddly unnerving, look at the brain--but it may prove useful to researchers,

Read more : Google brain! | Views : 1145 | Replies : 6

Chlorinative stress

This abstract doesn't directly mention MS, but it did come up in a search about MS. I found the mention of desferrioxamine intriguing because this is a substance which chelates both aluminium and iron from the body tissues so that you excrete them in urine and faeces. Wasn't there some research recently which found high levels of aluminium in the urine of people with RRMS, and high levels of iron in the urine of people ...
Read more : Chlorinative stress | Views : 786 | Replies : 0

Bullous Pemphigoid

No, I've never heard of it either, but look at the drugs listed in the second link--curious, but I suppose treatments are bound to overlap,



Read more : Bullous Pemphigoid | Views : 1010 | Replies : 1

Different perspective on cause of MS

Here's a researcher after the hearts and minds of ThisIsMS. I've never heard of this way of looking at MS before, and I'm not convinced, but it's good that some researchers are being more creative.

A possible cause and corresponding treatment for inflammatory, auto-immune or auto-aggressive diseases.

Med Hypotheses. 2007 Feb 20;
Gracia MC.
C/ Lopez de Aranda 35, 28027 Madrid, Spain.

This article develops the idea that many inflammatory, auto-immune ...
Read more : Different perspective on cause of MS | Views : 2896 | Replies : 18


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