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Reata Pharmaceuticals

This doesn't even qualify for the research pipeline since the company doesn't appear to have a specific drug targeted at MS yet, but they look like they're doing something a bit different by concentrating on protein misfolding.



Reata Announces Licensing of Novel Class of Anti-Inflammatory Compounds; Drugs Have Broad Potential Across Multiple Therapeutic Areas

April 17 - PRNewswire - Reata Pharmaceuticals, Inc. today announced the completion of a license agreement with Dartmouth College and The ...
Read more : Reata Pharmaceuticals | Views : 792 | Replies : 0


AI Disease, Response Starts Early, MS and Type 1 diabetes

Nick's foreword

I believe the following information is very important for a variety of reasons.
  • It reinforces the strong relationship between type 1 diabetes and MS. This studyby Winer et al in 2001 that found striking similarities between IDDM and MS. In essence, the two diseases are, in a test tube, virtually identical. It’s only their final expression of what self tissue is attacked which differs.
  • It compliments the research by Guggenmos et ...
Read more : AI Disease, Response Starts Early, MS and Type 1 diabetes | Views : 2839 | Replies : 12


Relapse occuring like flu?

Hey, I'm sorry to ask for advice again, but here goes.

I had imagined that relapses would be fairly straightforward ... like ... awakening to find a numbness in an arm or leg. But my first episode was a "flu" that got worse and worse until I wasn't able to walk or use my hands very well and was thinking and talking somewhat incoherently.

I had thought that was a freak onset. Except now I ...
Read more : Relapse occuring like flu? | Views : 1382 | Replies : 5


Viruses

Viruses have been suggested as triggers for "auto-immune" diseases including MS. There has been mounting evidence that a virus such as EBV may make one more susceptible. The following research suggests that an initial virus may lay dormant in the CNS and then reactivated later by another virus. Just a theory, but might explain why this disease has been so difficult to crack.

Ian

http://www.jci.org/cgi/content/abstract/JCI27372v1
Read more : Viruses | Views : 2788 | Replies : 17


Canadians

The Canadian MS Society has organised presentations in late April and in May about MS Research. Not sure if the venues are near to any users of this website but it would be good if someone could report back.

HarryZ - don't you live in London?

Ian


http://www.mssociety.ca/en/help/Medical ... ndHope.htm
Read more : Canadians | Views : 1333 | Replies : 11


Viruses and MS...again

HHV-6 vs EBV in a battle to decide which causes more cases of MS...coming soon to a theatre near you...



Human herpesvirus 6 and multiple sclerosis: a one-year follow-up study.

Brain Pathol. 2006 Jan;16(1):20-7.
Alvarez-Lafuente R, De Las Heras V, Bartolome M, Garcia-Montojo M, Arroyo R.
Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain. labesmul@hcsc.es

BACKGROUND: This study was undertaken in order to investigate the possible relation of HHV-6 ...
Read more : Viruses and MS...again | Views : 973 | Replies : 0


Head injuries not the cause

According to a recent report, head injuries do not seem to trigger the development of multiple sclerosis, a degenerative neurological disease. The hypothesis that trauma to the head might influence the development of multiple sclerosis in genetically predisposed individuals has been debated for several years, but the link has not been studied conclusively.
Researchers from Oxford University studied data for a group of over 110,000 people admitted to a hospital with head injury and analysed ...
Read more : Head injuries not the cause | Views : 1169 | Replies : 1


Axonal loss

In recent years it has been recognised that axonal loss is the main cause of permanent disability. The traditional view is that attacks by the immune sytem result in demyelination and that the underlying nerve fibres (axons) degenerate. The damage is considered to take place under the lesions which form where de-myelination has occurred. As with everything connected with this disease - nothing is straightforward. Attached is an article which suggestes that demyelination and axonal ...
Read more : Axonal loss | Views : 1200 | Replies : 5


Glutamate

Glutamate has often been cited as being involved in the cascade of events in MS. The following research suggests that there might be a drug to help (I must admit I found the article difficult to decipher).

Ian



http://www.msif.org/en/research/researc ... ptors.html
Read more : Glutamate | Views : 981 | Replies : 1


2006 - Good Year?

Dear all,

As you Canadians emerge from you igloos, think of me returning today from ten days in paradise - Mauritius. For the price of half a year's interferon I got - more Vit D than I could handle, a testosterone boost (girls in bikinis), lovely vegetables and fruit (Swank diet for ten days), and best of all, massages from someone trained in traditional Indian massage - US$15 for an hour). But I'll stop boasting. ...
Read more : 2006 - Good Year? | Views : 1353 | Replies : 5


 

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