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More evidence of B cell involvement

Cerebrospinal Fluid B Cells Correlate with Early Brain Inflammation in Multiple Sclerosis 07 July 2008

Background

There is accumulating evidence from immunological, pathological and therapeutic studies that B cells are key components in the pathophysiology of multiple sclerosis (MS).

Methodology/Principal Findings

In this prospective study we have for the first time investigated the differences in the inflammatory response between relapsing and progressive MS by comparing cerebrospinal fluid (CSF) cell profiles from patients at the ...
Read more : More evidence of B cell involvement | Views : 1532 | Replies : 0


Temporary paralysis - ten second flashes

Hi to all,

I have a question. For about a month I'm getting partial temporary paralysis to my left hand and parts of my face - mostly lips, chin and the right eye. It happens every few (15 or so) minutes for about 10 seconds - I can't use my left hand, can't speak, I kind of freeze. After 10 seconds or so I get well again.

It's a strange feeling during the "flash" - ...
Read more : Temporary paralysis - ten second flashes | Views : 5713 | Replies : 13


Can I get your opinions please?

Hi everyone,

So I am completely confused and would like some opinions. In March, I got the flu and after the flu was done, I noticed that my left side wasn't working as well as my right. I ended up going to the ER, and was admitted. I had an MRI which showed a lesion on the right side of my brain. My neurologist in the hospital seemed to think this was a viral thing. ...
Read more : Can I get your opinions please? | Views : 3905 | Replies : 17


does rrms lead to ppms?

I know this question has been asked before , but being new to the whole ms thing. Do you think that rrms leads to ppms? how many of you started out w/ rrms and then later were told it was ppms? I am only looking for answers as to what to my future holds. I know everyone is different, just looking for the general consensus. Thanks, arti
Robbie did you start out w/ rrms? hope ...
Read more : does rrms lead to ppms? | Views : 3302 | Replies : 16


To Copaxone or not to Copaxone

Hi All,

My 33 year old wife is facing a decision on Copaxone and I'd be interested in people's feedback. :)

Bit of background - she had her first Optic Neuritis 11 years ago and subsequently has had one more Optic Neuritis 4 years ago and a Sensory relapse this year - so 3 relapses in 11 years. In all cases she has recovered 99%.

After the ...
Read more : To Copaxone or not to Copaxone | Views : 2751 | Replies : 8


PPMS - does it always mean the patient will end up bedbound?

The more I read about PPMS - and of course seeing the worst examples on the internet -- the more scared I become.

My H was dx in 2000 after having sx since 1994 -- he has PPMS but can still walk with two canes, drives and goes to work -- needs no assistance from me with personal activities of daily living.

Are we looknig at a future ( our supposedly great retirement) with hoyer ...
Read more : PPMS - does it always mean the patient will end up bedbound? | Views : 3053 | Replies : 12


Hookworm to fight allergies

This might be intersting to some, who are watching helminth immun-modulation for MS:

http://www.medgadget.com/archives/2008/ ... tment.html

--Frank
Read more : Hookworm to fight allergies | Views : 1565 | Replies : 0


hay fever and relapse?!

Hi @all,

maybe someone has an idea or a similar experience...

Have you ever experienced any connection between allergy (as e.g. hay fever) and relapses?

The phenomenon: my younger sister (dx with MS Nov 2006) has severe hay fever, she always needs antihistamine etc. in spring and summer. Now she has a relapse ( :( ) with changes in sensation in her leg but the strange thing: ...
Read more : hay fever and relapse?! | Views : 3238 | Replies : 10


Support Group?

I want to start by thanking everyone o this site, there is a wealth of information shared, as well as just a good attitude.

I work for the Advocate health System, and am involved in opening an offsite Imediate Med Care place quite close to where I live.
The building has a community room which no one seems to have a use for as yet.

My thought was to start an MS support group for ...
Read more : Support Group? | Views : 1834 | Replies : 9


Bike the US for MS - coming to a town near you.

Greetings!

My name is Donald Fraser and I have created a fundraiser for MS research called "Bike the US for MS". We will be biking from Virginia to Oregon, and volunteering along the way. If MS affects you or your family, we want to stop and meet you. Please email info@biketheusforms.org if you live close to the route. Visit www.biketheusforms.org for route information.

My ...
Read more : Bike the US for MS - coming to a town near you. | Views : 1578 | Replies : 2


 

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