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Inosine & ms

URLPubmed

I take Inosine, and think it helps, but have to buy it from the U.S.,(expensive). Anyone found it in the U.K.? "RhosT" on 'ms news' points out that it is also commonly used as an anti-herpes drug, and HHV often crops up in relation to MS.

Dom.
Read more : Inosine & ms | Views : 1931 | Replies : 7


Minocycline & BBB effects

This may be old news to some, but its new to me. I had thought mino only worked due to its ant-inflamatory properties, but it also appears to reduce the BBB disruptions.

Minocycline Improves Neurological Outcome and Reduces BBB Disruption, Hemorrhage, and Perivascular Microglial Accumulation In Vivo
http://stroke.ahajournals.org/cgi/content/full/37/4/1087

A second agent that acts at the BBB is minocycline. Matrix metalloproteinases (MMPs) are produced during inflammation and contribute to the degradation of the basement membrane. This step ...
Read more : Minocycline & BBB effects | Views : 986 | Replies : 1


Prolactin

Just saw on the Canadian Global TV News network this evening an article about Prolactin and its apparent effect on pregnant MS patients.

These women produce Prolactin during pregnancy and they discovered that Prolactin rebuilds myelin in the brain lesions of the poor MS mouse. The researchers are likely going to spend two more years testing this on other animals and then depending what they discover, try it on humans.

Here is the link.

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Read more : Prolactin | Views : 2893 | Replies : 19


ABC News Primetime Interview

Hello all. I posted my intro in that forum but also wanted to post here to spread the word.

ABC News Primetime interviewed me for my story in fighting MS. It is hosted by Jay Schadler and should air sometime in the next couple months. The special is titled: Chronic Lyme Disease as it Pertains to ALS and MS. Two other patients were interviewed to my knowledge and one was Amy Tan (Author Joy Luck ...
Read more : ABC News Primetime Interview | Views : 1878 | Replies : 5


Fingolimod?

I'm debating a couple of trials to go for. Fingolimod seems the most promising, but the Copaxone/Steroid one seems likely. Has anyone done the clinical trial with Fingolimod? I'm interested, I'm kinda scared of Respritory Infections and all that Jazz. Please get back to me, very scared, confused and just plain sick of thinking about it.

Thanks!
Read more : Fingolimod? | Views : 1158 | Replies : 0


Stearic Acid

A group of researchers in Shanghai seems to be doing a lot of research into the neuroprotective effects of stearic acid.



Neuroprotective effects of stearic acid against toxicity of oxygen/glucose deprivation or glutamate on rat cortical or hippocampal slices.

Acta Pharmacol Sin. 2006 Feb;27(2):145-50.
Wang ZJ, Li GM, Tang WL, Yin M.
School of Pharmacy, Shanghai Jiaotong University, Shanghai 200030, China. myin@sjtu.edu.cn

AIM: To observe the effects of stearic acid, ...
Read more : Stearic Acid | Views : 1057 | Replies : 0


Pregnancy hormones

Research is coming through thick and fast at the moment.

Ian


Pregnancy hormone key to repairing nerve cell damage 19 February 2007

New research offers hope for treatment for multiple sclerosis and other neurological disorders.

The mystery of why multiple sclerosis (MS) tends to go into remission while women are pregnant may be the secret to overcoming the devastating neurodegenerative disease, according to University of Calgary researchers who have shown that a pregnancy-related hormone ...
Read more : Pregnancy hormones | Views : 1417 | Replies : 6


Promoting myelin repair

This sounds interesting, mind you, it would be much more interesting if I was a mouse...



A recombinant human IgM promotes myelin repair after a single, very low dose.

J Neurosci Res. 2007 Feb 15;
Warrington AE, Bieber AJ, Ciric B, Pease LR, Van Keulen V, Rodriguez M.
Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota.

A recombinant human monoclonal IgM, rHIgM22, promotes the synthesis of new ...
Read more : Promoting myelin repair | Views : 1352 | Replies : 0


IGF-1R in Graves Disease

Possible links with MS?

Researchers Identify Factor In Pathogenesis Of Graves' Disease

Science Daily — Investigators at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) have found evidence that continues to implicate insulin-like growth factor receptor (IGF-1R) in the development of Graves' disease.

In previous research published in the Journal of Immunology, Terry J. Smith, M.D. and Raymond Douglas, M.D., Ph.D. have identified the interaction between immunoglobulins and IGF-1R as a ...
Read more : IGF-1R in Graves Disease | Views : 1520 | Replies : 5


Nerve stuff

Getting On Your Nerves ... And Repairing Them 16 February 2007

In a study to be published in the March 2007 issue of The FASEB Journal, scientists from East Carolina University report that a key molecular mechanism, RNA interference (RNAi), plays a role in the regeneration and repair of periphery nerves, which are the nerves located outside of the brain and spinal column. This research may lead to new therapies that manipulate RNAi to ...
Read more : Nerve stuff | Views : 1051 | Replies : 1


 

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