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Potential Risk of Progressive Multifocal Leukoencephalopathy

Potential Risk of Progressive Multifocal Leukoencephalopathy With Natalizumab Therapy

Possible Interventions

Olaf Stüve, MD, PhD; Christina M. Marra, MD; Petra D. Cravens, PhD; Mahendra P. Singh, PhD; Wei Hu, MD, PhD; Amy Lovett-Racke, PhD; Nancy L. Monson, PhD; J. Theodore Phillips, MD, PhD; Jan W. Cohen Tervaert, MD, PhD; Richard A. Nash, MD; Hans-Peter Hartung, MD; Bernd C. Kieseier, MD; Michael M. Racke, MD; Elliot M. Frohman, MD, PhD; Bernhard Hemmer, MD

Arch Neurol. 2007;64:169-176. ...
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Determinants of Cerebral Atrophy Rate

Determinants of Cerebral Atrophy Rate at the Time of Diagnosis of Multiple Sclerosis

Bas Jasperse, MD; Arjan Minneboo, MD; Vincent de Groot, MD; Nynke F. Kalkers, MD, PhD; Paul E. van Helden, MSc; Bernard M. J. Uitdehaag, MD, PhD; Frederik Barkhof, MD, PhD; Chris H. Polman, MD, PhD

Arch Neurol. 2007;64:190-194.

Objective To identify determinants visible on magnetic resonance imaging of the brain that explain the subsequent rate of cerebral atrophy in patients with recently ...
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Inflammation may be protective

THELINKISHEREBOB inflammation is a good thing :?

Read more : Inflammation may be protective | Views : 1277 | Replies : 1

BBB leaks in lesions

If you can get through all the numbers and jargon in this abstract, I think it says that there is a small amount of BBB leakage in non-active lesions, and that natalizumab does nothing to stop this.


PS Special clue for you, Bob: try clicking on the words 'leakyBBB' :D
Read more : BBB leaks in lesions | Views : 1157 | Replies : 4

Lipoic Acid

Somewhat promising link regarding Lipoic Acid:

Lipoic acid stimulates cAMP production in T lymphocytes and NK cells.
Biochem Biophys Res Commun. 2007 Mar 2;354(1):259-64.
Read more : Lipoic Acid | Views : 1541 | Replies : 6

informing the DVLA for those in the UK

Here's a question for people from the UK,
Having to update a paper License, we find there is a clause where you have to mention if you have an illness which could progress to your inability to drive. How many people have let the DVLA know they are ill, is the information safe from anyone besides them finding out, and does telling them mean you have to have a driving test again?
Thanks for any ...
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negative oligoclonal bands

hi folks,

when i went through my diagnostics with my neuros (there was more then one), my CSF was negative for the oligoclonal bands...i have since read articles stating that around 10-15% of people positive for MS have this result with their CSF studies...i don't know if this is an old topic or not, but i was just wondering if anyone else also had a negative CSF...and, if so, if anyone has any info on ...
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rHIgM22 immunglobuline to build new myelin

I wanted to share that interesting article i just came across:

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Read more : rHIgM22 immunglobuline to build new myelin | Views : 7473 | Replies : 21

Clotting disorders and MS

I have been sent for tests to find out why I keep having miscarriages. I know Hughes syndrome is a nice outcome to get if you've MS, but sadly I have tested negative for Hughes, and thankfully, negative for Lupus.
But I have been told today I have another clotting disorder, but I'll find out which one on tues (dontcha love the medical profession!)
My head is in a whirl... ...
Read more : Clotting disorders and MS | Views : 1586 | Replies : 8


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