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Good day for mice

National Multiple Sclerosis Society Awards Grant to KU Researcher 15 May 2007

Teruna Siahaan, professor of pharmaceutical chemistry at the University of Kansas, has won a research grant from the National Multiple Sclerosis Society. Siahaan will use the award to investigate experimental treatments for Multiple Sclerosis involving a promising compound of his own discovery.

"We're thrilled that Dr. Siahaan has joined the movement to a world free of MS," said Kay Julian, president of ...
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Testosterone May Benefit Men With Multiple Sclerosis

Be careful with testosterone treatments. Read this article...

Testosterone May Benefit Men With Multiple Sclerosis

By Randy Dotinga
HealthDay Reporter

MONDAY, May 14 (HealthDay News) -- Testosterone gel may slow the progression of multiple sclerosis in men with the disease, a new study suggests.

Only 10 men took part in the research, all had milder forms of MS, and more studies will be needed before doctors determine whether the treatment really works. Still, the researchers ...
Read more : Testosterone May Benefit Men With Multiple Sclerosis | Views : 1409 | Replies : 1


NMSS summary of the AAN conference

Here is the NMSS' summary of the recent AAN conference.

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Ian
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Low Estrogen in Men Correlates with Disability

Here’s another abstract from the AAN.

Researchers found estradiol (form of estrogen) tended to be low in men with MS and correlated with disability. The researchers question whether men with MS might have a problem converting testosterone to estradiol.

They also found testosterone levels did not correlate with disability in men or women and that testosterone levels were increased in women (contrary to previous studies).

Serum Levels of Estradiol Correlate with Disability in Men with ...
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Vibrogym/power plate/vibrating platforms

Hi folks

Has anyone had any experience of using these?

I had a few sessions and the first was the most effective. Since then the impact has not been the same. :?

I'd be interested to hear from anyone who has been using one of these machines for a while......

Thanks

J
Read more : Vibrogym/power plate/vibrating platforms | Views : 1819 | Replies : 2


VZV vaccination useful for MS?

Hello,

in the context of possible viral causes/triggers of MS, would you think that it might be usefull for me to get a VZV vaccination?

Though I'm already infected with VZV, the vaccine showed, that it lowers the severety of a new active VZV infection.

Thanks for your suggestions.
--Frank
Read more : VZV vaccination useful for MS? | Views : 1531 | Replies : 2


Herpes viruses again

Human endogenous retroviruses are ancient fragments of viral DNA which have become part of our own DNA, and have been linked to the development of MS. So have various herpes viruses. This team has discovered that even inactive herpes viruses can activate these ancient genes in white blood cells. Herpes simplex -1, (the cold sore virus), and human herpes virus -6 produce a time-limited response, while the Varicella-zoster virus, (chicken pox/ shingles), produces a sustained ...
Read more : Herpes viruses again | Views : 1485 | Replies : 0


Blocking VLA-2 doesn't encourage PML.

The problem with drugs like Tysabri is that they not only prevent white blood cells from crossing the blood brain barrier and causing harm, they prevent them crossing and doing good things, like keeping viruses and PML in check.
This team took a different approach by blocking a molecule which interacts with the extracellular matrix, (basically, parts of tissue which are not part of the cell), and thus, so long as they get the timing ...
Read more : Blocking VLA-2 doesn't encourage PML. | Views : 1269 | Replies : 0


Non-infectious contributions to MS

It hadn't occurred to me before that smoking might be a risk factor which could explain the increase of MS in women, (in the UK at least, women and young girls smoke far more than men and boys). I would have thought it should be fairly easy to correlate the figures. Sunlight exposure, along with the myriad other non infectious environmental conditions, will be harder to quantify.
This from PubMed:

Environmental risk factors for multiple ...
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Phase II High-Dose Cyclophosphamide for Multiple Sclerosis

I can't help digging around in the information regarding "resetting" the immune system. I find it darned interesting. Notice who they are recruiting in this trial....
Bob

http://clinicaltrials.gov/ct/show/NCT00296205?order=5

Inclusion Criteria:

* Diagnosis of secondary progressive (SPMS), primary progressive (PPMS) or progressive relapsing (PRMS) multiple sclerosis
* A diagnosis of MS will be established by fulfilling criteria “Recommended Diagnostic Criteria for Multiple Sclerosis: Guidelines from the Internal Panel on ...
Read more : Phase II High-Dose Cyclophosphamide for Multiple Sclerosis | Views : 1301 | Replies : 0


 

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