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Nutrigenomics/Epigenetics

Nutrigenomics: The Genome–Food Interface
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137135/

"Efforts to unveil the etiology of human disease often recapitulate the nature versus nurture debate. But today’s biologists concede that neither nature nor nurture alone can explain the molecular processes that ultimately govern human health. The presence of a particular gene or mutation in most cases merely connotes a predisposition to a particular disease process. Whether that genetic potential will eventually manifest as a ...
Read more : Nutrigenomics/Epigenetics | Views : 379 | Replies : 0


PQQ?

Has anyone tried PQQ (Pyrroloquinoline Quinone)?

Doctor's Best wrote:PQQ with BioPQQ ™ helps provide neuro-protective properties which help inhibit memory loss, improve cognitive function, reduce neuropathic discomfort, and protect the entire central nervous system. PQQ is a polyphenol whose antioxidant properties are crucial for protecting energy-producing mitochondria. PQQ also acts as an enzyme co-factor essential for the biogenesis of new mitochondria and the stimulation of nerve growth factor.



Beneficial effects of a pyrroloquinolinequinone-containing dietary formulation on ...
Read more : PQQ? | Views : 460 | Replies : 4


2014 study: Vits A, D & E and altered MS inflammation

Increasing serum levels of vitamin A, D and E are associated with alterations of different inflammation markers in patients with multiple sclerosis
https://journals-scholarsportal-info.pr ... mipwms.xml

"Our main findings are that
(i) rising 25(OH)D (vitamin D) levels are positively associated with IL-1Ra and sFRP3, but only before IFN-β treatment,
(ii) rising retinol (vitamin A) levels are negatively associated with PTX3 both before and during IFN-β treatment and
(iii) rising α-tocopherol ...
Read more : 2014 study: Vits A, D & E and altered MS inflammation | Views : 320 | Replies : 0


2014 review: Evidence for Beneficial Role of Vitamin A in MS

The Evidence for a Beneficial Role of Vitamin A in Multiple Sclerosis
https://link.springer.com/article/10.10 ... 014-0148-4
Vitamin A is an essential nutrient with important roles in immunological responses and in brain development. Its main metabolite is retinoic acid (RA), which is responsible for the neuroimmunological functions related to vitamin A. In the brain, RA is known to have interactions with other nuclear receptor-mediated signalling pathways. RA is involved in plasticity, ...
Read more : 2014 review: Evidence for Beneficial Role of Vitamin A in MS | Views : 295 | Replies : 0


Magnesium is lower in MS patients

Magnesium was found to be significantly lower in MS patients vs. controls.

Comparison of serum Concentration of Se, Pb, Mg, Cu, Zn, between MS patients and healthy controls.
Electron Physician. 2016 Aug 25;8(8):2759-2764.

    INTRODUCTION: Multiple Sclerosis (MS) is defined as one of the inflammatory autoimmune disorders and is common. Its exact etiology is unclear. There are some evidences on the role of environmental factors in susceptible genetics. The aim of this study is to evaluate ...
Read more : Magnesium is lower in MS patients | Views : 379 | Replies : 3


2016 review:case for zinc treatment for cancer (fascinating)

OT but still auto-immune stuff so:

Decreased zinc in the development and progression of malignancy: an important common relationship and potential for prevention and treatment of carcinomas
free full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183570/
Abstract
Introduction

Efficacious chemotherapy does not exist for treatment or prevention of prostate, liver, and pancreatic carcinomas, and some other cancers that exhibit decreased zinc in malignancy. Zinc treatment offers a potential solution; but its support has been ...
Read more : 2016 review:case for zinc treatment for cancer (fascinating) | Views : 469 | Replies : 0


2017 review: Nutritional Considerations for Healthy Aging

Nutritional Considerations for Healthy Aging and Reduction in Age-Related Chronic Disease
free full text: http://advances.nutrition.org/content/8/1/17.2.full.pdf

Excerpts:
"A projected doubling in the global population of people aged >60 y by the year 2050 has major health and economic implications, especially in developing regions. Burdens of unhealthy aging associated with chronic noncommunicable and other age-related diseases may be largely preventable with lifestyle modification, including diet. However, as adults age they become ...
Read more : 2017 review: Nutritional Considerations for Healthy Aging | Views : 427 | Replies : 0


Vinpocetine?

Has anyone tried vinpocetine? It's been cited to increase cerebral perfusion.

http://www.altmedrev.com/publications/7/3/240.pdf

Clinical Indications: Chronic Cerebral Vascular Ischemia
Two PET studies in chronic stroke patients have shown that vinpocetine has a significant effect in increasing glucose uptake and metabolism in the healthy cortical and subcortical regions of the brain, particularly in the area surrounding the region of the stroke. 21 A study in 15 chronic ischemic stroke patients found ...
Read more : Vinpocetine? | Views : 407 | Replies : 1


Supplement info site

I recently ran across the site Examine.com and it looks like a good source for getting basic background information on supplements. Their supplements section contains a fairly well rounded list of 396 supplements that might be of interest.
Read more : Supplement info site | Views : 445 | Replies : 1


2009 case study review: GERD, PPIs, magnesium & D3

i found this article by searching the literature for magnesium and d3 interactions. although it only looks at one older female patient, the data is still interesting.
the play by play:

Hypomagnesaemia due to use of proton pump inhibitors – a review
https://www.njmonline.nl/getpdf.php?id=788
Abstract
"Magnesium homeostasis is essential for many intracellular processes and depends on the balance of intestinal absorption and renal excretion. Hypomagnesaemia may arise from various disorders. ...
Read more : 2009 case study review: GERD, PPIs, magnesium & D3 | Views : 586 | Replies : 0


 

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