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Inhibition of Histamine Response by Zinc

Inhibition of Histamine Response by Zinc
https://www.karger.com/Article/Abstract/135963

"Zinc cream has been used for many years in the treatment of skin conditions and allergy. In modern times it has been replaced by cortisone and antihistamine. Zinc has also recently been advised in cases of malnutrition, where zinc levels are low, to aid wound healing.
In this paper we have investigated the effect of zinc on histamine and SRS responses as ...
Read more : Inhibition of Histamine Response by Zinc | Views : 440 | Replies : 2


low uric acid: association with endothelial dysfunction

recall:

reference range of uric acid is typically 3.4–7.2 mg/dL (200–430 µmol/L) for men, and 2.4–6.1 mg/dL for women (140–360 µmol/L)

average ms patient level: 194 umol/L; healthy controls 290-300 umol/L

an association with endothelial health:

Depletion of Uric Acid Due to SLC22A12 (URAT1) Loss-of-Function Mutation Causes Endothelial Dysfunction in Hypouricemia
https://www.jstage.jst.go.jp/article/ci ... /-char/ja/
Background: Uric acid (UA) serves as an antioxidant in vascular endothelial cells. UA transporter 1 ...
Read more : low uric acid: association with endothelial dysfunction | Views : 1125 | Replies : 0


review: without cofactors, Vit D can help you absorb toxins

reposting in case anyone wasn't clear on the importance of cofactors (Luongo...!)

Vitamin D, Essential Minerals, and Toxic Elements: Exploring Interactions between Nutrients and Toxicants in Clinical Medicine
https://www.hindawi.com/journals/tswj/2015/318595/abs/
In clinical medicine, increasing attention is being directed towards the important areas of nutritional biochemistry and toxicant bioaccumulation as they relate to human health and chronic disease. Optimal nutritional status, including healthy levels of vitamin D and essential minerals, is ...
Read more : review: without cofactors, Vit D can help you absorb toxins | Views : 578 | Replies : 0


2018 paper: Role of divalent metals in infectious disease

i look forward to digging in on this one.

Role of divalent metals in infectious disease susceptibility and outcome
http://www.clinicalmicrobiologyandinfec ... 98-743X(17)30051-4/fulltext#sec2
"...From the microbial perspective, divalent metals are essential for growth and pathogenicity and to mount effective protection against antimicrobial host responses, including toxic radical formation. Microbes have evolved multiple strategies to control their access to divalent metals. From the clinical perspective, alterations of divalent metal levels may ...
Read more : 2018 paper: Role of divalent metals in infectious disease | Views : 497 | Replies : 1


Thiamine for MS

Two papers showing a benefit of thiamine in MS separated by 40 years without much published in between. Why?

High dose thiamine improves fatigue in multiple sclerosis (2013)
https://www.ncbi.nlm.nih.gov/pmc/articl ... 009144.pdf

Multiple sclerosis and other demyelinating diseases (1973)
https://www.ncbi.nlm.nih.gov/pmc/articl ... 9-0017.pdf
Read more : Thiamine for MS | Views : 618 | Replies : 5


abridged peer review: Matsugasumi et al, 2018 zinc study

The Association between Taste Impairment and Serum Zinc Concentration in Adult Patients with Type 2 Diabetes (Matsugasumi et al, 2018)
https://www.sciencedirect.com/science/a ... 7117303751
Abstract
Objectives
In this study, we aimed to elucidate the association between taste acuity and serum zinc concentration in patients with type 2 diabetes.
Methods
We enrolled 29 patients who were hospitalized to attend a 2-week diabetes educational program. Fasting blood samples were obtained on the ...
Read more : abridged peer review: Matsugasumi et al, 2018 zinc study | Views : 517 | Replies : 0


1974 study: Mg deficit: poss cause of refractory low vit B1

happened on this tiny old study while looking at something else altogether:

Magnesium deficiency: a possible cause of thiamine refractoriness in Wernicke-Korsakoff encephalopathy
http://jnnp.bmj.com/content/37/8/959.short

The determination of blood transketolase before and serially after thiamine administration, and the response of clinical symptomatology after thiamine are reported in two normomagnesaemic patients and one hypomagnesaemic patient with acute Wernicke-Korsakoff encephalopathy. The response of the depressed blood transketolase and the clinical symptoms was ...
Read more : 1974 study: Mg deficit: poss cause of refractory low vit B1 | Views : 557 | Replies : 0


slamming the zinc reference range

they say zinc just gradually 'gets lower' as part of the aging process. but what does that mean exactly? lower than what? how do we know when to take action?

to my mind, zinc (and other) 'normal' ranges are massively and ultimately unethically deceptive

case in point. here is a selection of zinc reference or normal ranges

Zinc, Serum
https://www.mayomedicallaboratories.com ... etive/8620
Normal serum zinc is 0.66 to 1.10 ...
Read more : slamming the zinc reference range | Views : 557 | Replies : 0


summary of daily intake

Hello,

I'd like to summarize, after searching on this forum (what I beleive to be)the most important daily intake needed for a MSer.
Can you pls confirm whether I'm correct?
Did I miss something?

-D3 Vit: UI 4000
-B12 (methylcobalamin): 1000 µg
-Zinc (picolinate or other):50 mg
-Magnesium (Glycinate): 300 mg
-Calcium: 1200 mg

There is an interaction between:
-D3 and Magnesium: solution is to take them at different time
-D3 and Zinc?

Thks
Read more : summary of daily intake | Views : 739 | Replies : 9


2017 Review: C, D & Zinc: Synergistic Roles Immune Function

Vitamins C, D and Zinc: Synergistic Roles in Immune Function and Infections (2017)
free full text: https://pdfs.semanticscholar.org/2c3b/8 ... 4b12f2.pdf

"Abstract
The immune system is a complex and sophisticated network of specialized tissues, organs, cells, proteins, and chemicals which has evolved in order to protect the host from a range of dangerous agents such as bacteria, virus, fungi, and parasites. There is a close relationship between nutritional status and immune ...
Read more : 2017 Review: C, D & Zinc: Synergistic Roles Immune Function | Views : 723 | Replies : 0


 

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