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2009 case study review: GERD, PPIs, magnesium & D3

i found this article by searching the literature for magnesium and d3 interactions. although it only looks at one older female patient, the data is still interesting.
the play by play:

Hypomagnesaemia due to use of proton pump inhibitors – a review
"Magnesium homeostasis is essential for many intracellular processes and depends on the balance of intestinal absorption and renal excretion. Hypomagnesaemia may arise from various disorders. ...
Read more : 2009 case study review: GERD, PPIs, magnesium & D3 | Views : 877 | Replies : 0

Will try curcumin + piperine

Hello There,

Can experienced people regarding nutriments (Jimmy Legs, NHE, Elliot, others?) help here?

I will try the combo curcumin+piperine as it should help to repair spinal cord & axon injuries...

However, I am already taking a lot of supplements, so I'm afraid of interactions between these products.

Here is the list of my supplements (per day) :
-Magnesium: 300mg
-Vit B6: 2mg
-vit D: 4000UI
-Omega3: 525mg
-Vit B12 (methylcobalamin): 1000µg
-Biotin: 300mg ...
Read more : Will try curcumin + piperine | Views : 893 | Replies : 6

Buyer Beware: Shady Supplements

So I was investigating a new supplement I saw advertised in the coupons from my Sunday paper. It's called Cognium and it's sold by Natrol. A website was given where many good things were said about it, e.g., it enhances glucose uptake in neurons, it improves cerebral blood flow, it binds to beta-amyloid and reduces clusters and tangles, it enhances cognitive and memory performance and on and on. It sounds like everything an MS patient ...
Read more : Buyer Beware: Shady Supplements | Views : 884 | Replies : 0

Liposome-based immunotherapy, therapeutic effect on MS

Liposome-based immunotherapy against autoimmune diseases: therapeutic effect on multiple sclerosis.
Nanomedicine (Lond). 2017 Jun;12(11):1231-1242.

    AIM: Based on the ability of apoptosis to induce immunological tolerance, liposomes were generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our aim was to validate the immunotherapy in other autoimmune disease: multiple sclerosis.

    MATERIALS & METHODS: Phosphatidylserine-rich liposomes were loaded with disease-specific autoantigen. Therapeutic capability of liposomes was assessed in vitro and in vivo.

    RESULTS: Liposomes ...
Read more : Liposome-based immunotherapy, therapeutic effect on MS | Views : 1119 | Replies : 0

Vitamin D increases regulatory T cells

Vitamin D modulates different IL-17-secreting T cell subsets in multiple sclerosis patients.
J Neuroimmunol. 2016 Oct 15;299:8-18.

    Vitamin D deficiency is an environmental risk factor for MS, a Th17 cell-mediated autoimmune disease that results in demyelination in the CNS. Therefore, we aimed to evaluate the ability of in vitro 1,25(OH)2D in modulating different Th17 cell subsets in MS patients in remission phase. In the present study, the production of Th17-related cytokines (IL-1β, IL-6, IL-17, IL-22), ...
Read more : Vitamin D increases regulatory T cells | Views : 789 | Replies : 0

Low vitamin D linked to increased risk of cognitive decline

Vitamin D Levels and the Risk of Cognitive Decline in Chinese Elderly People:
the Chinese Longitudinal Healthy Longevity Survey.

J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1363-8.

    BACKGROUND: Vitamin D has a neuroprotective function, potentially important for the prevention of cognitive decline. Prospective studies from Western countries support an association between lower vitamin D level and future cognitive decline in elderly people. No prospective study has examined this association in Asia.

    METHODS: This community-based ...
Read more : Low vitamin D linked to increased risk of cognitive decline | Views : 695 | Replies : 0

Vitamin D reduces relapse rate in RRMS treated with Tysabri

Vitamin D supplementation reduces relapse rate in relapsing-remitting multiple sclerosis patients treated with natalizumab.
Mult Scler Relat Disord. 2016 Nov;10:169-173.

    BACKGROUND: Vitamin D insufficiency is common among multiple sclerosis patients, and hypovitaminosis D has been associated with multiple sclerosis (MS) risk and disease activity.

    OBJECTIVE: To investigate how recommendations on vitamin D3 supplements affect 25-hydroxyvitamin D (25(OH)D) levels in patients with relapsing-remitting MS (RRMS) and to examine the clinical effects associated with changes in 25(OH)D ...
Read more : Vitamin D reduces relapse rate in RRMS treated with Tysabri | Views : 753 | Replies : 0

Low vitamin D predicts early conversion to SPMS

A low vitamin D status at diagnosis is associated with an early conversion to secondary progressive multiple sclerosis.
J Steroid Biochem Mol Biol. 2016 Nov;164:254-257.

    Low circulating 25-hydroxyvitamin D (25(OH)D) levels have been associated with an increased risk of relapses in relapsing remitting multiple sclerosis (RRMS), but an association with disability progression is uncertain. Lower 25(OH)D levels are found in secondary progressive MS (SPMS) when compared to RRMS. We hypothesized that a poor vitamin D ...
Read more : Low vitamin D predicts early conversion to SPMS | Views : 711 | Replies : 0

Magnesium Supplementation in Vitamin D Deficiency

Magnesium Supplementation in Vitamin D Deficiency.
Am J Ther. 2017 May 3.

    BACKGROUND: Vitamin D and magnesium (Mg) are some of the most studied topics in medicine with enormous implications for human health and disease. Majority of the adults are deficient in both vitamin D and magnesium but continue to go unrecognized by many health care professionals.

    AREAS OF UNCERTAINTY: Mg and vitamin D are used by all the organs in the body, and their ...
Read more : Magnesium Supplementation in Vitamin D Deficiency | Views : 871 | Replies : 1


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