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A board to discuss Revimmune as a potential therapy for multiple sclerosis

Cyclophosphamide so-so verdict in progressive MS

Patients with secondary progressive multiple sclerosis who were able to stay on cyclophosphamide therapy had a lower risk of further disability, but their dropout rate from treatment was more than twice that for methylprednisolone therapy, researchers reported here.

Of the 72 patients enrolled in the cyclophosphamide arm of the trial, 33 dropped out of treatment before the end of the 2-year study -- 20 of them due to adverse events, reported Bruno Brochet, MD, chief ...
Read more : Cyclophosphamide so-so verdict in progressive MS | Views : 3087 | Replies : 3

Symptoms right after 1st HICY infusion?


I am currently undergoing HSCT (Hematopoietic Stem Cell Transplantation) with Dr Burt in Chicago which also involves large doses of chimo - cyclophosphomide like revimunne. I had my first dose of chimo on Monday and was discharged to the local hotel afterwards.I have posted in the HSCT section of the forum but my concern was not addressed. And since my question is related to the chimo I decided to post here too.

My concern ...
Read more : Symptoms right after 1st HICY infusion? | Views : 3283 | Replies : 1

Plans unveiled for new MS drug study for Cyrevia


The leading physicians from Accentia Biopharmaceuticals, Inc. and Johns Hopkins University have presented plans for a randomized clinical trial to study Cyrevia (formerly Revimmune) in multiple sclerosis (MS) to a number of key opinion leaders in the field and potential site investigators. Johns Hopkins University will serve as the lead trial site for the study.

Physicians also co-hosted a meeting with prospective clinical trial investigators at the recent American Academy of Neurology (AAN) Annual ...
Read more : Plans unveiled for new MS drug study for Cyrevia | Views : 3827 | Replies : 0

HiCy in Europe

Hello, I'm new to the disease and the forum :(. I'm searching for a cure like everyone else and the things I'm considering are HSCT or HiCy. Just can't find any information for trials or even where to pay in Europe for HiCy. As far as I understand it can be done in every cancer clinic and it is not anything new, just when I asked my ...
Read more : HiCy in Europe | Views : 5033 | Replies : 8

Cyrevia (Formerly Revimmune)

In December, Accentia Bio changed the name of their Multiple Sclerosis therapy Revimmune (HiCy or High Dose Cytoxan) to Cyrevia.

As the company is working toward starting PH III trials this year, it is also registered the domain name to reserve the name for Cyrevia.

In step with these announcments, Johns Hopkins has stated "We're in the planning stages of trying to have a larger multi-center clinical trial ...
Read more : Cyrevia (Formerly Revimmune) | Views : 4283 | Replies : 1

Is cyclo really going to help?

I'm 19 and I decided to do cyclo and I have been home for 4days and was in the hospital for 9 to do the cyclo, but I am already having a attack! So I am wondering if the cyclo is going to help can someone comment please? :sad:
Read more : Is cyclo really going to help? | Views : 3731 | Replies : 3

Analysis of 40 JH HiCy Patients

Treatment of RRMS with high dose cyclophosphamide induction

CyclophosphamideBackground: Previous studies have described stabilization of aggressive multiple sclerosis (MS) with one-time induction therapy with high-dose cyclophosphamide (HiCy). The long-term benefit of this stabilization followed by conventional therapy has not been explored.

Objective: The objective of this study was to evaluate the safety and clinical outcomes following treatment of relapsing-remitting MS with HiCy induction therapy followed by glatiramer acetate maintenance.

Methods: A retrospective review of ...
Read more : Analysis of 40 JH HiCy Patients | Views : 4806 | Replies : 6

Multiple Sclerosis drug Revimmune receives FDA designation


The U.S. Food and Drug AdministrationbizWatch U.S. Food and Drug Administration granted Orphan Drug Designation to Revimmune, Accentia Biopharmaceuticals Inc.bizWatch Accentia Biopharmaceuticals Inc.'s planned therapy to treat autoimmune diseases including multiple sclerosis.

With FDA Orphan Drug status, Accentia, based in Tampa, gains seven years of market exclusivity for Revimmune for systemic sclerosis and autoimmune hemolytic anemia upon its approval by the FDA, a company statement said.... Read More - ...

Gots me a date...

Finally, after months of staff changes and screw ups I have a date to enter RUSH's HiCy program.

I'm over the moon, but now that it's real I'M SCARED!

Oh well, pretty instinctual to be afraid of things like this.

I will be the oldest patient they have done there at 54. I kind of felt that their biggest concern is the potential for heart damage. I'm entering the study in pretty perfect health, except ...
Read more : Gots me a date... | Views : 4009 | Replies : 4

Hopkins video

Read more : Hopkins video | Views : 9054 | Replies : 23


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