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A board to discuss the anticipated multiple sclerosis treatment Rituxan.

Rituxan: Don't count it out as multiple sclerosis treatment

Numerous presentations at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) meeting made it plain that the anti-CD20 biologic drug ocrelizumab may not have the field to itself, if and when it is approved for marketing... Read more -
Read more : Rituxan: Don't count it out as multiple sclerosis treatment | Views : 461 | Replies : 0

"Inexpensive" B cell depletion. Low dose IT rituxan... ... 003053.pdf
Rapid depletion of B lymphocytes by ultra-low-dose rituximab delivered intrathecally
Objective: We are conducting an open-label phase 1b study on the efficacy of intrathecal (IT) administration of rituximab, provided via an Ommaya reservoir, for the treatment of progressive multiple sclerosis (PMS). The objective of this initial study was to monitor B lymphocytes in peripheral blood (PB) and CSF from the first 10 patients 1 year ...
Read more : "Inexpensive" B cell depletion. Low dose IT rituxan... | Views : 1007 | Replies : 2

Need feedback on the use of Rituxan

My neuro made a personal call to me this morning. My ms is acting particularly aggressive lately. He wants me to start rituxan. Does it work for you? What side effects have you experienced? How often have you had treatment? Do you get treatment intraveneously or intrathecally? Do they even offer this treatment intrathecally? I want to go in with my eyes wide open.

Read more : Need feedback on the use of Rituxan | Views : 1726 | Replies : 13

Side effects from Rituxan?

I am switching from Tecfidera to Rituxan, due to several new brain & spinal cord lesions despite being on Tecfidera for 13 months. I am wondering about possible side effects. My neuro seems to think since it is such an infrequent, low dose I may not experience too many ill effects. Did anyone have any hair loss or hormonal changes for women? Hearing your personal experiences is always more valuable than reading the FDA approved ...
Read more : Side effects from Rituxan? | Views : 1641 | Replies : 3

Rituxan if JC+?

I was diagnosed way back in 1991 (22 years ago). I've been incredibly lucky and "passed" up until about 3 years ago. I'm still mobile but have some balance and drop toe issues. I've been on all of the ABC meds, and am currently on Tecfidera and Ampyra. I developed antibodies to Tysabri on the third infusion. I also just tested positive for the JC virus. My neurologist is recommending Rituxan. She's less concerned with ...
Read more : Rituxan if JC+? | Views : 1688 | Replies : 2

Rituxan infusion schedule

I'm currently in Gilenya 2 months. I haven't had my blood work to see if I can remain on Gilenya.
I am interested in Rituxan as my neuro has mentioned it.
I was on Tysabri for 73 months and wonder what the dosing schedule is like.
What is a typical Rituxan infusion like?
Read more : Rituxan infusion schedule | Views : 1541 | Replies : 3

NIH study for SPMS underway on experimental drug Rituximab

There are currently no effective treatments for people with secondary-progressive MS who do not experience relapses or who do not have “active” lesions on MRI, however researchers at the National Institutes of Health in Bethesda, Maryland are evaluating the safety and effectiveness of Rituximab (trade names Rituxan and MabThera) – a new experimental drug for treating MS. In this study, Rituximab be delivered intravenously and directly into the cerebrospinal fluid by lumbar puncture of about ...
Read more : NIH study for SPMS underway on experimental drug Rituximab | Views : 1394 | Replies : 0

Moving to Rituxan from Tecfidera

I have been battling MS since 1999. Finally got diagnosed with SPMS. I have been without a spleen since 1974 due to trauma. Going for Rituxan from Tecfidera. Any tips or advice from those who have tried Rituxan? I know that we have to be weary of severe leucopenia and hepatitis B antibodies.
Read more : Moving to Rituxan from Tecfidera | Views : 2056 | Replies : 9

FDA adds boxed warning to Rituxan

Boxed Warning of HBV Risk Added to Rituxan ... eral/41864

The FDA announced today that rituximab (Rituxan) and ofatumumab (Arzerra) will now carry a boxed warning of the risk for immunosuppression-related reactivation of hepatitis B virus (HBV).

The two agents are anti-CD20-directed monoclonal antibodies used to treat chronic lymphocytic leukemia. Rituximab also is used for non-Hodgkin's lymphoma, rheumatoid arthritis, vasculitis, and other conditions.

Reactivation of HPV can occur ...
Read more : FDA adds boxed warning to Rituxan | Views : 1172 | Replies : 0

Immortalized mser B cells produce brain autoantibodies

Couldn't fit a decent title in...sorry if that was a bit misleading.

Immortalised B cell lines from multiple sclerosis patients produce autoreactive monoclonal antibodies ... KEN_ID=900
B cells and oligoclonal antibodies are present in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients but their target antigens remain unknown. The focus of this study was to produce autoantibodies of MS patients based on B cell immortalization and to ...
Read more : Immortalized mser B cells produce brain autoantibodies | Views : 1283 | Replies : 2


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