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A board to discuss the anticipated multiple sclerosis treatment Rituxan.

FDA adds boxed warning to Rituxan

Boxed Warning of HBV Risk Added to Rituxan ... eral/41864

The FDA announced today that rituximab (Rituxan) and ofatumumab (Arzerra) will now carry a boxed warning of the risk for immunosuppression-related reactivation of hepatitis B virus (HBV).

The two agents are anti-CD20-directed monoclonal antibodies used to treat chronic lymphocytic leukemia. Rituximab also is used for non-Hodgkin's lymphoma, rheumatoid arthritis, vasculitis, and other conditions.

Reactivation of HPV can occur ...
Read more : FDA adds boxed warning to Rituxan | Views : 1659 | Replies : 0

Immortalized mser B cells produce brain autoantibodies

Couldn't fit a decent title in...sorry if that was a bit misleading.

Immortalised B cell lines from multiple sclerosis patients produce autoreactive monoclonal antibodies ... KEN_ID=900
B cells and oligoclonal antibodies are present in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients but their target antigens remain unknown. The focus of this study was to produce autoantibodies of MS patients based on B cell immortalization and to ...
Read more : Immortalized mser B cells produce brain autoantibodies | Views : 1750 | Replies : 2

Autoantigen induced clonal expansion in immortalized B cells

Autoantigen induced clonal expansion in immortalized B cells from the peripheral blood of multiple sclerosis patients ... 2813001343
We studied Ig heavy chain (VDJ) sequences and antigen reactivity of 412 immortalized B cell lines from the peripheral blood of 10 multiple sclerosis (MS) patients, 4 clinically isolated syndrome (CIS) patients and 6 healthy controls (HCs). 78/238 (32.8%) MS and CIS B cell lines were part of 9 clonally ...
Read more : Autoantigen induced clonal expansion in immortalized B cells | Views : 1547 | Replies : 0

Rituximab kills auto reactive plasma B cells

I was worried about the ebv infected plasma cells escaping rituxan because plasma cells don't usually express cd20. Looks like there is a chance rituxan might kill those buggers after all. :)

Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis
Read more : Rituximab kills auto reactive plasma B cells | Views : 1506 | Replies : 0

MS-b cell tolerance defect-rituximab efficacy

In a study of 7 ms patients (small!), all tested positive for peripheral B cell tolerance defect. Two also tested positive for central B cell tolerance defect. Study authors propose those with only peripheral B cell tolerance defect will respond favorably and for a longer term to treatment with rituximab. They surmise the new B cells will be normal in those with peripheral B cell tolerance issues...and B cells will continue to be abnormal in ...
Read more : MS-b cell tolerance defect-rituximab efficacy | Views : 1621 | Replies : 0

My first Rituxan infusion

After waiting 6 months for approval, being on no meds during the wait, I am excited to start the Rituxan. However, I am anxious/nervous about the infusion. Will I be able to return to work the next day? Did anyone develop adverse side effects? I started on copaxone and did well for over a year. Then one night after an injection i quickly developed anyphylaxis (?) and had to go to the local er. not ...
Read more : My first Rituxan infusion | Views : 2961 | Replies : 6

Rituximab iv and intrathecal with valtrex

Hopefully I am jcv negative so we can proceed in October.

If all goes well, we'll be following standard protocol for ebv-related post transplant lymphoproliferative disease, systemically and in CNS. 375mg/m2 i.v. and 15mg i.t. (might increase) once a week for four weeks. It will all be done in his office. How convenient. :D

Have I mentioned I love my neuro?
Read more : Rituximab iv and intrathecal with valtrex | Views : 13604 | Replies : 127

Rituximab Relation to ocrelizumab

It turns out that Rituximab patent expires in the US in 2015. This means that, by the time the phase III is over, the patent will be over too. So, no profit then in doing such an investment. To surpass this inconvenience Genentech invented a new drug, antiCD20 as well, but humanized (Rituximab is chimeric), called Ocrelizumab, and started the whole process again. Then, obviously, we got a phase II trial with ocrelizumab in MS. ...
Read more : Rituximab Relation to ocrelizumab | Views : 3215 | Replies : 1

Very Successful Treatment with Rituxan

I was given my first treatment of Rituxan in January of 2012. Within two days of the first treatment, I had a great elimination of my symptoms. Additionally, I had ABSOLUTELY no reaction during or after to the drug Rituxan. By my third infusion, my body was able to handle the drug in under four hours. I see a doctor out of state, and I was able to immediately get up after each infusion and ...
Read more : Very Successful Treatment with Rituxan | Views : 3275 | Replies : 5

first infusion (RRMS)

just had my first infusion today.

i am still classified as RRMS and am probably doing quite well compared to many people who use these boards. however, after 8 years of mostly remission since my initial diagnosis, the last 6 months have been one thing after another -- numb, fumbling fingers; optic neuritis; and most recently weakness in my knees and fatigue after walking moderate distances. none of these have remitted so far-- the optic ...
Read more : first infusion (RRMS) | Views : 9194 | Replies : 31


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