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A board to discuss the anticipated multiple sclerosis treatment Rituxan.

Autoantigen induced clonal expansion in immortalized B cells

Autoantigen induced clonal expansion in immortalized B cells from the peripheral blood of multiple sclerosis patients ... 2813001343
We studied Ig heavy chain (VDJ) sequences and antigen reactivity of 412 immortalized B cell lines from the peripheral blood of 10 multiple sclerosis (MS) patients, 4 clinically isolated syndrome (CIS) patients and 6 healthy controls (HCs). 78/238 (32.8%) MS and CIS B cell lines were part of 9 clonally ...
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Rituximab kills auto reactive plasma B cells

I was worried about the ebv infected plasma cells escaping rituxan because plasma cells don't usually express cd20. Looks like there is a chance rituxan might kill those buggers after all. :)

Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis
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MS-b cell tolerance defect-rituximab efficacy

In a study of 7 ms patients (small!), all tested positive for peripheral B cell tolerance defect. Two also tested positive for central B cell tolerance defect. Study authors propose those with only peripheral B cell tolerance defect will respond favorably and for a longer term to treatment with rituximab. They surmise the new B cells will be normal in those with peripheral B cell tolerance issues...and B cells will continue to be abnormal in ...
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My first Rituxan infusion

After waiting 6 months for approval, being on no meds during the wait, I am excited to start the Rituxan. However, I am anxious/nervous about the infusion. Will I be able to return to work the next day? Did anyone develop adverse side effects? I started on copaxone and did well for over a year. Then one night after an injection i quickly developed anyphylaxis (?) and had to go to the local er. not ...
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Rituximab iv and intrathecal with valtrex

Hopefully I am jcv negative so we can proceed in October.

If all goes well, we'll be following standard protocol for ebv-related post transplant lymphoproliferative disease, systemically and in CNS. 375mg/m2 i.v. and 15mg i.t. (might increase) once a week for four weeks. It will all be done in his office. How convenient. :D

Have I mentioned I love my neuro?
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Rituximab Relation to ocrelizumab

It turns out that Rituximab patent expires in the US in 2015. This means that, by the time the phase III is over, the patent will be over too. So, no profit then in doing such an investment. To surpass this inconvenience Genentech invented a new drug, antiCD20 as well, but humanized (Rituximab is chimeric), called Ocrelizumab, and started the whole process again. Then, obviously, we got a phase II trial with ocrelizumab in MS. ...
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Very Successful Treatment with Rituxan

I was given my first treatment of Rituxan in January of 2012. Within two days of the first treatment, I had a great elimination of my symptoms. Additionally, I had ABSOLUTELY no reaction during or after to the drug Rituxan. By my third infusion, my body was able to handle the drug in under four hours. I see a doctor out of state, and I was able to immediately get up after each infusion and ...
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first infusion (RRMS)

just had my first infusion today.

i am still classified as RRMS and am probably doing quite well compared to many people who use these boards. however, after 8 years of mostly remission since my initial diagnosis, the last 6 months have been one thing after another -- numb, fumbling fingers; optic neuritis; and most recently weakness in my knees and fatigue after walking moderate distances. none of these have remitted so far-- the optic ...
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Copaxone or Rituxan

I have RR MS and have been using Copaxone for the last 3 years but my last MRI showed two new lesions on my spine. My Doctor has recommended Rituxan. After reading this forum and other information,
I am a little nervous. Has anyone else with RR used Rituxan and what was your experience? I have an appointment tomorrow morning and need to tell my Doctor what my decision? Then I can go forward with ...
Read more : Copaxone or Rituxan | Views : 3186 | Replies : 3

Third PML case reported with Rituximab


A case of progressive multifocal leukoencephalopathy (PML) has been reported in a rheumatoid arthritis patient taking rituximab (Rituxan) who had not previously received anti-tumor necrosis factor therapy, according to the FDA and the drug’s manufacturer.

The case is the third seen with rituximab in rheumatoid arthritis, according to a “Dear Healthcare Professional” letter issued by Genentech. The previous two were seen in patients who had received anti-TNF drugs earlier.

PML causes inflammation in the ...
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