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Discuss stem cells, adult and embryonic, and their therapeutic potential for MS here.

Off the shelf stems........

This company whose website is here

is creating an off the shelf mesenchymal stem cell product. The website is interesting and they have stage II/III trials going in Crohn's and graft vs host diseases with fast track status granted already.

Apparently they screen donors carefully and then harvest and grow the stem cells from these healthy people in the lab for donation to others.

from the website
Osiris ...
Read more : Off the shelf stems........ | Views : 2223 | Replies : 8

Prof Scolding stem cell trial

Not much in this article, but thought it worth posting.

Introducing stem cell based Myelin repair therapies in patients with Multiple Sclerosis

Professor Neil J. Scolding, FRCP PhD, University of Bristol Institute of Clinical Neurosciences, U.K., provided a report of his studies of bone-marrow derived cells for the treatment of multiple sclerosis.

About 30 years ago, investigators began to think that cell therapies might be useful to treat loss of myelin caused by multiple ...
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Stem Cells in MS review

This medscape article authored by Karoussis and Kassis found here
details the potential use of stem cells for MS. It discusses the different types of cells, studies that have been done, and the results. This paper is a REVIEW (IMHO the cadillac of papers- means somone looked extensively at a variety of other people's work on something) of cumulative research to date on the subject.

A logical treatment ...
Read more : Stem Cells in MS review | Views : 2536 | Replies : 10

Not MS: Transplant of windpipe grown from stem cells

I saw this on the standard daily TV news today.
To recap; the operation, on 30-year-old tuberculosis patient Claudia Castillo, took place in Barcelona, where doctors also had collected a three-inch segment of trachea from a 51-year-old donor who had died of a cerebral hemorrhage. They used a technique developed in Padua to strip the windpipe of its donor's original cells, a procedure that took six weeks, to create a "scaffold". At the same time, ...
Read more : Not MS: Transplant of windpipe grown from stem cells | Views : 1849 | Replies : 1

Stem cells for MS

Here is the abstract from pubmed on the Karussis stem cell work (NOTE there is no chemo in this treatment it is JUST stem cells):

Immunomodulation and neuroprotection with mesenchymal bone marrow stem cells (MSCs): a proposed treatment for multiple sclerosis and other neuroimmunological/neurodegenerative diseases.Karussis D, Kassis I, Kurkalli BG, Slavin S.
Department of Neurology and Laboratory of Neuroimmunology and the Agnes-Ginges Center for Neurogenetics, Hadassah-Hebrew University Hospital, Ein-Karem, Jerusalem, IL-91120, Israel. ...
Read more : Stem cells for MS | Views : 3313 | Replies : 12

Iran invests $2.5b in stem cell research

The Iranians have already done stem cell testing on human MS patients, and continue to forge ahead with stem cell research. Politics aside, kudos to them in this regard.

I also found it interesting that the article notes that Muslim clerics declare that life begins three months after conception. Thus, they don't have the moral dilemma that most Western countries do...
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Japanese researchers make brain tissues from stem cells!!!!

TOKYO (AFP) – Japanese researchers said Thursday they had created functioning human brain tissues from stem cells, a world first that has raised new hopes for the treatment of disease.

Stem cells taken from human embryos have been used to form tissues of the cerebral cortex, the supreme control tower of the brain, according to researchers at the government-backed research institute Riken.

The tissues self-organised into four distinct zones very similar to the structure seen ...
Read more : Japanese researchers make brain tissues from stem cells!!!! | Views : 1705 | Replies : 0

New neurons

I think this is old news but it is today's date!

Neurons Can Regrow! 27 October 2008

There’s evidence that the adult human brain has the ability to grow new neurons, say researchers at the Cleveland Clinic Lerner Research Institute.

The study included nine people with multiple sclerosis (MS) and a control group of four healthy people. In MS, the immune system destroys the myelin sheaths that surround and protect nerves. When the myelin ...
Read more : New neurons | Views : 1690 | Replies : 0

Stem Cells May Protect Brain Against Itself

Stem Cells May Offer Stroke-Damaged Brain Protection Against Itself
By Aalok Mehta
October 13, 2008

Stem cells can drastically reduce the amount of damage following a stroke by limiting the body’s natural “overreaction” to the trauma, a new animal study has found.

Scientists have long known that stem cells seem to offer some protection against stroke damage, but how they did it was not clear. Perhaps the stem cells replace the dying neurons and replicate ...
Read more : Stem Cells May Protect Brain Against Itself | Views : 1806 | Replies : 1


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