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A board to discuss the newly-released drug Tysabri, (formerly known as Antegren) as a treatment for Multiple Sclerosis

PML cases now reach 430

Latest "reported" cases of PML has risen by 7 last month to 430. Not known if any more related deaths.
Read more : PML cases now reach 430 | Views : 1424 | Replies : 13

PML cases now reach 423

PML cases have jumped 5 more from last month...up to 523. Not known if any additional deaths took place.
Read more : PML cases now reach 423 | Views : 1131 | Replies : 4


I'm new to the forum but I'm currently on tecfidera and have been on it for 4 months. I was on Gilenya and didn't have any relapses but decided to change after a year because of hair loss and headaches. As soon as I came off Gilenya I had major relapse transitioning to tecfidera. It took me almost two months to recover from this last relapse. I regret coming off Gilenya now but my Doc ...
Read more : Rebound | Views : 1021 | Replies : 2

Tysabri to start soon......

My neuro wants me to start Tysabri. I have done all kinds of research and read on this page. My thoughts have been scrambled on this issue for days. I just had JC bloodtests. He said his paitents both JC + and - are on it. I've Bernard on Copaxone, tecfidera and avonex and been sicker to different degrees on them. Life is too short to be sick 5 out of 7 days a week. ...
Read more : Tysabri to start soon...... | Views : 1548 | Replies : 13

relapse or something worse?

Hello all, I am brand new to the community. I was diagnosed with relapse/remitting MS in 2008. After a year or so on Copaxone, I got lazy and stopped taking the drug and my doc put me on Tysabri about two and a half years ago. All was going well until may/june of this year when I went in for my treatments every five weeks instead of the standard four week schedule. I did this ...
Read more : relapse or something worse? | Views : 1114 | Replies : 3

JCV index

I am JCV+. I used tysabri 73 times. I switched to tecfidera, used it for 4 months.
My neuro had me stop taking it. I had 1 flare and developed psoriasis while on tecfidera.
I want to get back on tysabri. I did the index blood test and I am a .46.
Does anyone know what this means? I want to know what my risk of PML is.
I have used Avonex, Rebif, Tysabri, and ...
Read more : JCV index | Views : 1881 | Replies : 8

PML Cases now reach 418

As of November 5, there are now 418 known cases of PML, 8 more than from the previous month. Don't know if there are any more deaths.
Read more : PML Cases now reach 418 | Views : 954 | Replies : 0

PML Cases now reach 410!

The number of known PML cases has now reached 410, an increase of 9 over the previous month. Don't know how many more deaths are involved in this number.

Read more : PML Cases now reach 410! | Views : 1127 | Replies : 0

IgM antibody identifies good candidates for natalizumab

Researchers in Spain have identified lipid-specific antibody bands in the cerebrospinal fluid (CSF) that are associated with an aggressive presentation of multiple sclerosis (MS), and patients with these antibodies seem to have a much lower risk for progressive multifocal leukoencephalopathy (PML) with natalizumab therapy (Tysabri, Biogen Idec).

"The presence of lipid-specific IgM bands in the CSF signals patients with aggressive disease and highly activated immune systems," said Luisa Villar, PhD, Hospital Ramón y Cajal, Madrid, ...
Read more : IgM antibody identifies good candidates for natalizumab | Views : 886 | Replies : 0

Tysabri may be possible for more MS patients with new test

A blood test for L-selectin expression on circulating immune cells may identify multiple sclerosis patients who could safely receive natalizumab (Tysabri) despite past exposure to the JC virus, a small study presented here suggested.

All MS patients taking natalizumab who developed the rare but life-threatening brain inflammation called progressive multifocal leukoencephalopathy (PML) in the study had very low levels of L-selectin expression, which was not seen in other patients who did not develop PML or ...
Read more : Tysabri may be possible for more MS patients with new test | Views : 1184 | Replies : 1


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