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A board to discuss the newly-released drug Tysabri, (formerly known as Antegren) as a treatment for Multiple Sclerosis

PML cases now reach 423

PML cases have jumped 5 more from last month...up to 523. Not known if any additional deaths took place.
Read more : PML cases now reach 423 | Views : 1488 | Replies : 4


I'm new to the forum but I'm currently on tecfidera and have been on it for 4 months. I was on Gilenya and didn't have any relapses but decided to change after a year because of hair loss and headaches. As soon as I came off Gilenya I had major relapse transitioning to tecfidera. It took me almost two months to recover from this last relapse. I regret coming off Gilenya now but my Doc ...
Read more : Rebound | Views : 1395 | Replies : 2

Tysabri to start soon......

My neuro wants me to start Tysabri. I have done all kinds of research and read on this page. My thoughts have been scrambled on this issue for days. I just had JC bloodtests. He said his paitents both JC + and - are on it. I've Bernard on Copaxone, tecfidera and avonex and been sicker to different degrees on them. Life is too short to be sick 5 out of 7 days a week. ...
Read more : Tysabri to start soon...... | Views : 2094 | Replies : 13

relapse or something worse?

Hello all, I am brand new to the community. I was diagnosed with relapse/remitting MS in 2008. After a year or so on Copaxone, I got lazy and stopped taking the drug and my doc put me on Tysabri about two and a half years ago. All was going well until may/june of this year when I went in for my treatments every five weeks instead of the standard four week schedule. I did this ...
Read more : relapse or something worse? | Views : 1487 | Replies : 3

JCV index

I am JCV+. I used tysabri 73 times. I switched to tecfidera, used it for 4 months.
My neuro had me stop taking it. I had 1 flare and developed psoriasis while on tecfidera.
I want to get back on tysabri. I did the index blood test and I am a .46.
Does anyone know what this means? I want to know what my risk of PML is.
I have used Avonex, Rebif, Tysabri, and ...
Read more : JCV index | Views : 2563 | Replies : 8

PML Cases now reach 418

As of November 5, there are now 418 known cases of PML, 8 more than from the previous month. Don't know if there are any more deaths.
Read more : PML Cases now reach 418 | Views : 1279 | Replies : 0

PML Cases now reach 410!

The number of known PML cases has now reached 410, an increase of 9 over the previous month. Don't know how many more deaths are involved in this number.

Read more : PML Cases now reach 410! | Views : 1496 | Replies : 0

IgM antibody identifies good candidates for natalizumab

Researchers in Spain have identified lipid-specific antibody bands in the cerebrospinal fluid (CSF) that are associated with an aggressive presentation of multiple sclerosis (MS), and patients with these antibodies seem to have a much lower risk for progressive multifocal leukoencephalopathy (PML) with natalizumab therapy (Tysabri, Biogen Idec).

"The presence of lipid-specific IgM bands in the CSF signals patients with aggressive disease and highly activated immune systems," said Luisa Villar, PhD, Hospital Ramón y Cajal, Madrid, ...
Read more : IgM antibody identifies good candidates for natalizumab | Views : 1221 | Replies : 0

Tysabri may be possible for more MS patients with new test

A blood test for L-selectin expression on circulating immune cells may identify multiple sclerosis patients who could safely receive natalizumab (Tysabri) despite past exposure to the JC virus, a small study presented here suggested.

All MS patients taking natalizumab who developed the rare but life-threatening brain inflammation called progressive multifocal leukoencephalopathy (PML) in the study had very low levels of L-selectin expression, which was not seen in other patients who did not develop PML or ...
Read more : Tysabri may be possible for more MS patients with new test | Views : 1627 | Replies : 1

New Tysabri data from ECTRIMS

New Tysabri data show earlier treatment & longer-term use result in significant reductions in MS disease activity

Biogen Idec announced results from several new analyses of Tysabri(R) (natalizumab) data that demonstrate its effectiveness in reducing multiple sclerosis (MS) disease activity. This effect was particularly significant in people with relapsing MS who initiated treatment when they had lower Expanded Disability Status Scale (EDSS) scores as well as in those who have been treated for more than ...
Read more : New Tysabri data from ECTRIMS | Views : 1422 | Replies : 1


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