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A board to discuss the newly-released drug Tysabri, (formerly known as Antegren) as a treatment for Multiple Sclerosis

PML Cases Now Reach 302

The number of increased PML cases with Tysabri use now sits at 302. This is the smallest increase (4) in cases in a number of months. Not sure if that's due to Tysabri users stopping usage after 2 years or JC virus testing before starting the drug.

Harry

http://chefarztfrau.de/?page_id=716
Read more : PML Cases Now Reach 302 | Views : 1165 | Replies : 2


Lethal MS following Tysabri withdrawal

Here's a recent case report documenting the death of an MS patient from immune reconstitution inflammatory syndrome (IRIS) following Tysabri withdrawal.

Lethal Multiple Sclerosis Relapse After Natalizumab Withdrawal
Neurology. 2012 Oct 24.

    Natalizumab dramatically reduces relapses in patients with active multiple sclerosis (MS), but it may induce progressive multifocal leukoencephalopathy (PML).(1) A rebound of MS or an immune reconstitution inflammatory syndrome (IRIS) were described after natalizumab withdrawal, even in the absence ...
Read more : Lethal MS following Tysabri withdrawal | Views : 2469 | Replies : 3


tysabri wash out period

anyone spoken with their neuros about a wash out period before switching to another drug? im at 48-50 infusions and lookin to switch with biogens new info released about pml for those of us further than 48 infusions... im lookin for an alternate route to the 30 days of solumedrol my neuro is talking about... just curious as to what others might be doing. i posted in the bg12 section and have gotten no replies, ...
Read more : tysabri wash out period | Views : 1897 | Replies : 4


please tell me, what suppliments could I take with tysabri?

please tell me, what vitamins and suppliments could I take while making tysabri ?
Read more : please tell me, what suppliments could I take with tysabri? | Views : 1007 | Replies : 1


Anyone else have low potassium while on Tysabri?

I cannot get my potassium levels up and its getting worse and worse! The doctors cannot figure out why I cannot keep potassium in my system. We should have around 4700 mgs in our bodies daily with diet and I take 9750 mgs a day in SUPPLEMENTS just to keep it barely minimum levels! The only thing I can attribute this to is the Tysabri treatments. I've been on Tysabri for over 4 years and ...
Read more : Anyone else have low potassium while on Tysabri? | Views : 838 | Replies : 0


Doctor wants to switch me to this but I'm scared stupid.

The virus seems like a major risk, maybe not worth it. My dad hates the idea as well after reading up on it.

The thing about it is the risk goes up the longer you are on it, then if you get off of it you are kind of screwed because you get worse than you were before and very quickly. Am I wrong about any of this?

Any experiences with RRMS?
Read more : Doctor wants to switch me to this but I'm scared stupid. | Views : 2191 | Replies : 23


PML Cases now reach 298

Sadly, the number of PML cases has jumped to 298 an increase of 14 over the previous month. The total number of deaths associated with this are 63.

http://chefarztfrau.de/?page_id=716
Read more : PML Cases now reach 298 | Views : 2768 | Replies : 15


Serious CNS Herpes/Varicella infections/2 deaths

September 10, 2012 (San Francisco, California) — At least 17 patients taking natalizumab have experienced serious herpes simplex or varicella zoster infections since November 2004, researchers reported here at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy.

Most of the patients underwent long hospitalizations and received systemic antiviral therapy; 2 died.

The risk for central nervous system (CNS) infection is already included in the labeling of natalizumab, but this research confirms the danger, first ...
Read more : Serious CNS Herpes/Varicella infections/2 deaths | Views : 1473 | Replies : 1


Looking to start Tysabri

I am trying to decide if I should start Tysabri. One of my biggest fears is the rebound effect of having to stop the Tysabri. I don't have any garantee I can take it. I guess 2 yrs max.
Bg-12 is soon to come out we hope. I know it is not suppose to be as good.
I am progressing and that scares me. I do think Ty is the best drug.
I have to ...
Read more : Looking to start Tysabri | Views : 2376 | Replies : 17


MSRC Tysabri Diary Updates

Kirsty has sent in her 18th & 19th Tysabri infusion updates.

You can read her new diary entries at http://bit.ly/u3SoFn

Jill has kindly sent in her last and final Tysabri diary entry, as she is switching to Gilenya due to JC Virus results.

We would like to thank Jill for all her Tysabri diaries and wish her good luck with Gilenya.

You can read Jill's final diary entry at ...
Read more : MSRC Tysabri Diary Updates | Views : 2409 | Replies : 11


 

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