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A board to discuss the newly-released drug Tysabri, (formerly known as Antegren) as a treatment for Multiple Sclerosis

Tysabri appears OK for expectant mothers with MS

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Accidental fetal exposure to natalizumab did not appear associated with shorter mean birth length, lower mean birth weight, or lower mean gestational age in pregnant multiple sclerosis patients, according to small studies presented here.

Based on data from an MS and MS and pregnancy registry in Germany, seven babies born to MS patients were exposed to natalizumab (Tysabri) during the third trimester and two were found to have profound anemia at birth, but both ...
Read more : Tysabri appears OK for expectant mothers with MS | Views : 1078 | Replies : 0


New Tysabri data presented at AAN Meeting

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Biogen Idec and Elan Corporation announced findings from several studies of Tysabri(R) (natalizumab) evaluating its long-term safety and efficacy in the treatment of multiple sclerosis (MS) across the course of disease and impact on MS-related symptoms such as fatigue. These data, as well as data relating to the companies' risk stratification algorithm as a way to help enable individual benefit risk assessment for patients with MS, were accepted for presentation at the 64th Annual ...
Read more : New Tysabri data presented at AAN Meeting | Views : 1001 | Replies : 0


Australian "Teenager denied MS drug"

He has had MS from about 10 years of age.

http://au.news.yahoo.com/video/national/watch/29090259/
Read more : Australian "Teenager denied MS drug" | Views : 1149 | Replies : 3


Patients dropping MS drug Tysabri face relapse risk

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Multiple sclerosis patients treated with natalizumab were more likely to discontinue therapy after learning of a positive JCV antibody result, only to see a higher risk for relapse, according to a small, single-center study reported here.

Of nine patients who discontinued natalizumab (Tysabri) after learning their antibody result, which indicated a heightened risk for progressive multifocal leukoencephalopathy (PML) -- a rare but life-threatening event -- five relapsed within 6 months, said Denise Cheng, RN, ...
Read more : Patients dropping MS drug Tysabri face relapse risk | Views : 836 | Replies : 0


Antibody to α4 integrin suppresses natural killer cells

Antibody to α4 integrin suppresses natural killer cells infiltration in CNS

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Abstract
Natalizumab inhibits the influx of leukocytes into the central nervous system (CNS) via blockade of alpha-4 subunit of very late activation antigen (VLA)-4.

The association of natalizumab therapy with progressive multifocal leukoencephalopathy (PML) suggests a disturbance of CNS immune surveillance in a small percentage of Multiple Sclerosis (MS) patients exposed to the medication.

Natural killer (NK) cells are known to play an ...
Read more : Antibody to α4 integrin suppresses natural killer cells | Views : 1193 | Replies : 0


The Tysabri Debacle - from Dr. Ashton Embry (direct-ms.org)

This was posted on one of the fb groups that I follow. An interesting read for a newbie like me, for some its probably old news, but interesting none the less.

Death and Dividends: The Tysabri Debacle
 
 
For the last three to four years neurologists have been talking about the coming of a much more effective drug for MS. That drug was first called Antegren and then Tysabri. The story of Tysabri illustrates ...
Read more : The Tysabri Debacle - from Dr. Ashton Embry (direct-ms.org) | Views : 1950 | Replies : 7


212 PML cases and 46 deaths in Tysabri MS patients

212 PML cases and 46 deaths in Tysabri MS patients as of March 1st 2012

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Biogen Idec have released the latest figures for PML cases and deaths following Tysabri infusions for Multiple Sclerosis

As of March 1, 2012, there have been 212 PML cases, of which 122 have been in the European Economic Area (EEA), 80 in the US and 10 in rest of world (ROW). 46 of the 212 patients with PML have ...
Read more : 212 PML cases and 46 deaths in Tysabri MS patients | Views : 2602 | Replies : 3


Tysabri long-term use anyone?

I've been on Tysabri for over seven (7) years. I've had almost 100 infusions. I was part of the clinical trial beginning (for me) Aug 2002 and went through to open label in Dec 2004. I had two open label infusions when it was yanked due to PML deaths. The double blind on the study was broken to find out that I was on the drug during the study. I went back on Tysabri April ...
Read more : Tysabri long-term use anyone? | Views : 4353 | Replies : 15


tysabri and LDN

Hi
Does anyone know or have experience of taking ldn while on tysabri? Is it contraindicated?

thanks and regards
M
Read more : tysabri and LDN | Views : 1062 | Replies : 1


Febuary 1, 2012: 207 PML cases on natalizumab (44 deaths)

Since January 2012 (as of Febuary 1), there have been six more PML patients and two more deaths.
It means 207 confirmed cases of PML and 44 of them have died (21%). :evil:
There have been about 98.000 MS patients on natalizumab worldwide.
Read more : Febuary 1, 2012: 207 PML cases on natalizumab (44 deaths) | Views : 1809 | Replies : 2


 

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