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A board to discuss the newly-released drug Tysabri, (formerly known as Antegren) as a treatment for Multiple Sclerosis

First-line use of Tysabri in anti-JCV antibody negative pts

Applications for first-line use of Tysabri in anti-JCV antibody negative patients with MS announced


Biogen Idec and Elan Corporation, plc have announced that they have submitted applications to the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) requesting updates to the Tysabri® (natalizumab) labels. The applications request an expanded indication that would include first-line use for people living with certain relapsing forms of multiple sclerosis (MS) who have tested negative for ...
Read more : First-line use of Tysabri in anti-JCV antibody negative pts | Views : 1153 | Replies : 2

Tysabri is doing AMAZINGLY for me until the last week

Like the last week to week and a half it's like I'm not on any medication and I relapse really hard. As far as I know there is only one type of dose, what are some solutions your doctor has for you? My next infusion is coming up and I'll ask my doctor then.
Read more : Tysabri is doing AMAZINGLY for me until the last week | Views : 1130 | Replies : 1

JC Virus Test Vs. Tysabri Antibody T itre


Does anyone know the difference between the JCVirus and the Tysabri Antibody Titre?
Read more : JC Virus Test Vs. Tysabri Antibody T itre | Views : 1628 | Replies : 9

Tsyabri Efficacy Rate

Does anyone know the efficacy rate of Tysabri? I tried to find it on pubmed, but I don't really know where to look in the endless reports.
Read more : Tsyabri Efficacy Rate | Views : 1324 | Replies : 7

PML Cases now reach 312

Unfortunately the number of PML cases has made another significant jump by 10 in the last month, bringing the total to 312. Don't know if any more deaths have resulted.

Read more : PML Cases now reach 312 | Views : 1468 | Replies : 4

Endless illness

Just curious if anyone has gone through the things I have. Started Tysabri 2 months ago so, 2 infusions. I have not stopped vomiting and having diarreah since then. Terrible stomach pain and constant nausea. My Neuros seem a bit lost and only hear that I possibly developed an antibody to Tysabri. I have researched a ton and have not found any similar long term issues. They suspended my infusions immediately and I have been ...
Read more : Endless illness | Views : 1477 | Replies : 5


I am very interested in MS and hopefully they will eventually find a cure. My brother was diagnosed at the age of 28. He has a very aggressive and debilitating case of MS. He can barely walk now at the age of 38. He took Avonex for awhile but has been on tysabri for about 5 or 6 years now. He has not had anymore flare up but his condition is not getting any better. ...
Read more : Chickenpox | Views : 1460 | Replies : 2

PML Cases Now Reach 302

The number of increased PML cases with Tysabri use now sits at 302. This is the smallest increase (4) in cases in a number of months. Not sure if that's due to Tysabri users stopping usage after 2 years or JC virus testing before starting the drug.

Read more : PML Cases Now Reach 302 | Views : 1184 | Replies : 2

Lethal MS following Tysabri withdrawal

Here's a recent case report documenting the death of an MS patient from immune reconstitution inflammatory syndrome (IRIS) following Tysabri withdrawal.

Lethal Multiple Sclerosis Relapse After Natalizumab Withdrawal
Neurology. 2012 Oct 24.

    Natalizumab dramatically reduces relapses in patients with active multiple sclerosis (MS), but it may induce progressive multifocal leukoencephalopathy (PML).(1) A rebound of MS or an immune reconstitution inflammatory syndrome (IRIS) were described after natalizumab withdrawal, even in the absence ...
Read more : Lethal MS following Tysabri withdrawal | Views : 2529 | Replies : 3

tysabri wash out period

anyone spoken with their neuros about a wash out period before switching to another drug? im at 48-50 infusions and lookin to switch with biogens new info released about pml for those of us further than 48 infusions... im lookin for an alternate route to the 30 days of solumedrol my neuro is talking about... just curious as to what others might be doing. i posted in the bg12 section and have gotten no replies, ...
Read more : tysabri wash out period | Views : 1955 | Replies : 4


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