Significantly lower BDNF values were found in unstimulated and stimulated PBMC supernatants of patients with SP MS compared to control subjects. This reduction was greater in patients with a 1-point increase in the EDSS score in the last 6 months compared with that in patients without a progression of the disability score. Reduction in the levels of BDNF was also confirmed in the CSF of SP MS patients compared with R-R MS patients assessed during a stable phase of the disease and control subjects.
BDNF was positively correlated with E(2) and progesterone and negatively correlated with menopausal age.
CONCLUSION: DHEA-S plays a key role in the pathogenesis of adult-onset acne. Measurement of circulating androgens, including DHEA-S, especially in patients presenting with adult-onset acne and hirsutism, is helpful, and patients with elevated levels can benefit from hormonal therapy.
progesterone as reffered to some trials doesn't help in MS contrary to estriol-estradiol (estrogen that the body produces from DHEA) that stop MS progression in some cases!
On the other hand progesterone probably in synthetic form may cause cancer while DHEA hasn't such effects, I wonder why your physician recommended progesterone, is there any problem with the DHEA supplementation at all?
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