Actually, I've recently discussed L-Arginine supplementation with Dr. John Cooke (Stanford, author of Cardiovascular Cure) and during the last 7 years, his position and that of his colleagues has changed on L-Arginine supplementation. They no longer recommend it.
However, two well-designed studies raised red flags about arginine supplements and the heart. One, conducted by researchers at Stanford University and published in Circulation in 2007, found that arginine supplements did not help people with peripheral arterial disease and may even have made matters worse. “Not useful” was the conclusion. And a study at Johns Hopkins Hospital in 2006 found that arginine supplements given to heart attack patients dramatically increased deaths. The study had to be halted; researchers warned strongly against using arginine for heart attack patients.
http://www.berkeleywellness.com/supplem ... -can-it-do
What Dr. Cooke and cardiovascular researchers are saying is that it takes lifestyle changes, not supplements.
I never put L-Arginine in the Endothelial Health program--because the theory is that rather than using a supplement to increase nitric oxide, it's best to let the body create its own.... (You're right to differentiate iNOS and eNOS)
Increasing endothelially derived NO takes a lifestyle. Complete with UV rays, whole foods, smoking cessation, exercise, meditation, weight loss (if indicated) and a bunch of other measures.
http://www.ccsvi.org/index.php/helping- ... ial-health
It works, but it takes work.