This Is MS Multiple Sclerosis Community: Knowledge & Support

Overwhelmed: Reversing Endothelial Dysfunction in Autoimmune Disease by Cheerleader

-edited to explain the endothelium for those new to this concept...
the endothelium is the single cell layer of our blood vessels. This lining utilizes nitric oxide to control blood pressure, vascular dilation, and immune response. I've come to see that my husband's MS (and perhaps others) is linked to his vascular system. His current program was put together with new research on molecular medicine, antioxidants, vasodilators and the endothelium-


EDIT: The original program is now available as a note on Facebook:
https://www.facebook.com/note.php?note_id=123456602210
or, an abbreviated version is available at CCSVI Alliance
http://www.ccsvi.org/index.php/helping- ... ial-health

This was written for friends, family and folks who wanted info on Jeff's program and what we've learned over the past two years. I wanted to share it with my thisisms family, in the hope it may be of service. I'm not a doctor, or scholar, or expert. But I do love someone with MS, and I'm slightly ocd.
best,
the aging cheerleader (AC)

poste script...since I began this thread, there have been some exciting developments in the study of the vascular connection to MS. Please refer to the thread on CCSVI (Chronic cerebrospinal venous insufficiency) in the general forum for more information. Doppler technology has allowed researchers to see venous blockage in MS patients. I believe we're just beginning to scratch the surface of endothelial dysfunction. AC

http://www.thisisms.com/ftopict-6488.html

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

Cheer your husband is, at least, very lucky with a helpmate like you!

Herbs, like ginkgo and salvia, which affect the endothelium, are to my mind DEFINITELY useful in MS.

_________________
3 years antibiotics, 06/09 bilateral jug stents at C1, 05/11 ballooning of both jug valves, 07/12 stenting of renal vein, azygos & jug valve ballooning,

I could say pycnogenol, resveratrol, gingko, omega-3 fatty acids, quercetin and EGCG from green tea work the same way gibbledygook!

All good suggestions, Gibbledy and DIM...they're in the paper. Thanks to you both for all the help, research and supplement input. I really owe you both so much...also a shout out to Jimmy. You guys kept me going and googling when I was scared witless. Here's to stability and healing,
AC

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

I must say, I'm immensely relieved to have found things that I can actually feel working within hours of consumption. It makes a huge change from the antibiotic experiment where v little could be determined in the short run.
Last night after my nightly dose I could feel my legs changing. The same applies to this morning. I take the medicine at 6:30am (ish) and about 40 minutes later I can feel stuff going on in my legs.

_________________
3 years antibiotics, 06/09 bilateral jug stents at C1, 05/11 ballooning of both jug valves, 07/12 stenting of renal vein, azygos & jug valve ballooning,

By the way Cheer I read Jeff continues to eat dairy products, with the research you did this year are you sure they won't make him worst?
I trully believe if there is a food that every person with MS should avoid this is milk and especially cow milk!

I agree, Dim. Dairy is not good for MS, but Jeff eats only a small amount of hard cheese, maybe one ounce a day. No other milk products. He changed his diet SO much....he used to live on cheeses, red meat, cold cuts, sausage and diet Dr. Pepper. He followed the "Atkins Diet" and he was constipated all the time, no surprise! Maybe someday he'll give up his cheese completely, but he has to want to do it.
AC

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

We've been discussing zonulin and its role in coeliac disease and MS. Perhaps a completely gluten/dairy free diet would bring even more healing to the BBB and endothelium throughout the body. Jeff is gluten free, maybe I'll start hiding his cheeses
AC

http://www.thisisms.com/ftopict-6328.html

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

Just downloaded your PDF...very readable, and glad you gave stressful living quite a big mention! In the year 1900 people use to be too busy to stew and dwell on things, they just got on with it.
Not sure about cooking with olive oil though, I've heard it can kill off the good stuff and even be bad for you....

Gainsbourg

Olive oil is by far the best oil for cooking IF you don't use very high temperatures, in every case if you want to use it for fry just add some onion in your frying-pan that prevents formation of oxidative and toxic substances and you are OK!

Thanks, gains. Yes, I do mention stress in relation to our body's release of cortisol being harmful to the endothelium. People have always had stress but I believe our hectic work schedules in today's technological age have taken away our "down time." This has increased cortisol levels for many.

As far as olive oil...from a study on virgin olive oil and endothelial health:
"Monounsaturated fats, such as olive oil rich in phenolic acid content, and vegetables help prevent endothelial activation and dysfunction in the postprandial state."
http://content.onlinejacc.org/cgi/content/full/48/2/413
We can trust Dmitris on this, he's our Mediterranean Diet expert
AC

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

In the news today, nine cases of MS attempting to link to cadium, mercury and metal poisoning in Illinois. Part of a lawsuit the tiny village of DuPue is lodging against Exxon/Mobil.

"The DePue Superfund site is 1,500 acres of land contaminated by heavy metals such as aluminum, barium, cobalt, mercury, nickel, zinc, lead, arsenic, cadmium, chromium and copper as the result of manufacturing operations on the site."
"Contaminants have been found in yards, gardens and play areas. Also, the Illinois Department of Public Health found cadmium, zinc and lead in dust wipe and carpet samples in 15 DePue homes. Furthermore, a 2001 study on the incidence of Multiple Sclerosis in DePue found nine cases of the disease in the village which statistically should have had less than two. This was considered "a highly significant excess of MS cases" as cited in the ordinance."
link


Heavy metals are extremely hard on the endothelium, and contribute to immune dysfunction and leakage in blood vessels....wrote about them in my paper. Feel sorry for these poor families, and hope they get some help.
AC

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

As you recently began the Vascular hypothesis is this the reason why Low Dose Naltrexone works so well for most MSers Cheer?

http://cat.inist.fr/?aModele=afficheN&cpsidt=13567004
http://jpet.aspetjournals.org/cgi/conte ... /220/3/625
http://www.pubmedcentral.nih.gov/articl ... id=2431172
http://www.springerlink.com/content/r42n273236h61215/
jnm.snmjournals.org/cgi/reprint/40/1/19.pdf

By the way it says "Neurological disability progressed in only one patient", quite interesting:
http://msj.sagepub.com/cgi/content/abstract/14/8/1076

(bear in mind we talk about low dose naltrexone that increases metenkephalins) http://www.springerlink.com/content/775 ... b74c2&pi=5

Interesting studies, Dmitris! Naltrexone certainly effects the vasculature.
We never did get Jeff going on LDN, since he's stable and doing so well on supplements and copaxone, but it's still on my list for the future. I hadn't looked into the vascular connections-
I think LDN's increase in endorphins and enkephalins provides the most benefit for MSers, but there's more research to be done, I'm sure.
AC

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS