How much Minocycline?

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How much Minocycline?

Postby Redd » Tue Feb 08, 2005 4:20 pm

Daunted,
On another board you posted minimum antibiotic concentration levels needed to effectively kill Cpn.

I was led to believe that 200mg of Minocycline, (100 mg twice daily) was effective in the treatment of Cpn but according to your infomation 400mg a day would be needed to suppress the bacteria?

I am still planning on the pulses of Metro after the 90 day's but I'm not sure what the correct amount of the Minocycline should be.

Sarah feel free to jump in as well, I would value your input.

Thanks, Redd...
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Re: How much Minocycline?

Postby Daunted » Tue Feb 08, 2005 5:57 pm

I just edited that post as I hadn't checked the information closely. If I can't answer the question I shouldn't leave it up! I left the list of potential antibiotics up, and that information can also be found in Stratton's patent.

Perhaps Sarah or someoene else can jump in here- but I am on 200mg a day of Doxycycline, myself.

My understanding is that Flagyl (metronidazole) gets into the CSF with no problems whatsoever, though, and Rifampin, as well.

I'm actually a bit confused as to the purpose of taking Zithromax (azithromycin) or Amoxicillin (which I am taking myself), since they don't cross the blood-brain barrier hardly at all. If I had to guess, I would say it is in order to prevent CPn in the body from infecting macrophages which then do cross the blood-brain barrier.
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Postby SarahLonglands » Wed Feb 09, 2005 5:16 am

Redd, yes 200 mg of doxycycline and I think the same amount for minocycline. You will have to check on that, because David has never prescribed it, but they are too similar to need vastly different dosages.

Daunted as well, I don't know about the amoxycillin but the zithromax is taken to avoid the danger of resistance. I take roxithromycin, also a macrolide, for this; it has the advantage of both getting through the BBB and working synergically with the doxycycline which has the effect of maximising the use of the two. It is not available on prescription in the US or Canada, unfortunately. Actually, it isn't licensed in this country either, but medical practitioners are allowed to prescribe it: it is imported from France. Try telling that to some GPs, though!

Rifampicin can be taken to get the same result and mino/doxy are far better taken with any of these, mainly to avoid resistance developing. It doesn't matter that they don't all cross the BBB because they don't all dutifully only start working when they pass that barrier. They will scoop up the CPn and anything else enroute. Daunted's guess seems pretty valid to me.

As far as the flagyl goes, best not to rush it, but introduce it gradually. The good thing about it is that you can choose when to take it according to you schedule. I am on day two of my second booster dose and am already feeling wiped out.

Anyway, Redd, when are you going to start your own regimens thread? :wink:

I'll do an update in about a week.

Sarah
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Postby Redd » Wed Feb 09, 2005 3:39 pm

Daunted, Sarah

Thank You both for your reply's. As you can see I post seldom, but I read the forum daily and I'm sincerely grateful for the wealth of information I receive from this site.

Sarah, the research and information you and your husband have shared as been so inspiring as well as educational.

Yes I will write my own regimen post, but like you I want to wait to the six month mark. I started the Minocycline December 1st and will add my first pulse of Metronidazole at the end of this month.

Thank You again for all your help.

Redd
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