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Progress on neural stem cells seem to be picking up.



Scientists create working brain cells

July 28, 2005 -- Reuters -- Swedish researchers have created new functioning brain cells from stem cells drawn from the brains of living adults, sparking hope that effective treatments for devastating illnesses like Parkinson's and Alzheimer's could be at hand, media reported overnight.

Neurosurgeons withdrew the stem cells from the brains of adults during routine surgery for hydrocephalus, or water on the brain, a researcher at the Stockholm Karolinska Institute told the Swedish daily Svenska Dagbladet.

As long as an agent was present to induce cell division, the extracted stem cells created new and working brain cells.

"So far we have managed to produce several millions of new cells from the original stem cells. About 25 percent of them are (active) neurons," Ulf Westerlund, who presented his doctoral thesis on the subject last week, told the paper.

When the researchers added glutamate, a salt that functions as a neurotransmitter in the central nervous system, the new cells communicated in a network, according to Westerlund.

"This means we had working synapse connections that are needed for nerve cells to work," he said.

Stem cells are nascent cells which can develop into replacement cells for damaged organs or body parts.

Researchers have long attempted to find ways of replacing dead brain cells with healthy ones in order to reverse the tragic effects of such diseases as Alzheimer's, Parkinson's and multiple sclerosis, in which the brain slowly dies.

In cooperation with the University of California at Los Angeles, Westerlund and other Swedish researchers have inserted the extracted human stem cells into the spinal marrow of rats, revealing that also there the cells continued to divide and create new cell neurons.

The injection of stem cells into the rats also appeared to lead to quicker recovery for allodynia, or pain that results from a non-injurious stimulus to the skin, according to Westerlund.

"The mere potential of these cells has had a significant impact of how we today evaluate the regenerative capacity of the central nervous system and, importantly, on the possible means for science to provide insights in neural repair," he wrote in his thesis.

http://www.news.com.au/story/0,10117,16 ... 09,00.html

Dignan,

Very good post - I've seen a number of references to neural stem cells over the past few months.

Describing MS as a disease where the brain slowly dies is hard to take (particularly on a full stomach). Unfortunately with MS it's also the spinal cord.

I suspect that the first to benefit, if this ever takes off, will be those with Parkinsons which tends to affect one type of brain cell (initially).

But if they could identify some effective neuro-protective treatment to save what we have got, neural stem cells might be the way to recover what we have lost.

I just wish my dx had come in 2014 rather than 2004. We seem to be in a bit of a no man's land at the moment where there seems to be lots of promising treatments in the pipeline e.g. stem cells etc but they are just out of reach at the moment.



Ian

I agree about 2014 vs 2004 (or 2003 in my case). An interesting aspect of the recent neural stem cell research is that the stem cells also appeared to have an unexpected ability to reduce inflamation. Who knows, maybe this will finally be something that lives up to the hype. I live in hope.