I have been on Tecfidera exactly 6 weeks. For 2 days no side effects. Starting day 3 I had horribly painful bloating, gassy stomach & terrible nausea. I had all the tips & tricks down & was doing everything right. Maybe the end of week 2 I was at the end of my rope & would have quit it if my sister-a nurse-hadn't talked me into riding it out. Coincidently the following Mon there was a post on this very board 'A year on Tecfidera'. It was the first positive post I'd seen from a woman who fought thru the side effects & was thrilled that she did so, feeling great, improved mri etc. That was exactly what I needed to soldier on, & I did. Week 3 was more of the same, horrible pain from bloating & nausea. I switched to taking it BETWEEN meals & that seemed to help somewhat. Mind you I was still on the strict schedule, eat 2hrs before, aspirin 1hr before & Zantac, Zofran, anti-gas 3x a day. At the start of week 4 I pretty much had it with the whole 'schedule' involved in taking this med! I had gained weight & was taking like 20 pills to ward off side effects, rediculous!! I decided to hell with that & started taking it with a small glass of milk (was still taking Zantac & gasx w Zofran as needed). Week 4 was great! Very few side effects, mind you I did have the occasional 'light/hot' head as I experienced it but I was fine w that. Over the past couple weeks I've given up the milk, Zantac & Zofran. I still take an aspirin an hour before (am only). I take it on an empty stomach as I've never been one to eat in the morning. I am back to my normal eating schedule & do nothing for taking Tecfidera but take it. My side effects are gone & I can FINALLY say it's easy to just take 2 pills a day, feeling hopeful that this is the medicine. Just know that every person is different, with different side effects & experiences. I just wanted to share my personal in hopes that it helps someone. Good luck to you all & may Tecfidera be the amazingly effective DMT people & Drs hope it is!!