I've been on Tecfidera just short of 6 months as of today. My first week on the low dose of the medicine was great, no symptoms. Week 2 of the higher dose was great, no symptoms till the end of that second week. I thought I had food poisoning for a few days...then, it diminished and it's been good ever since. I do get some "flushing" or as I call it "hair on fire", but it's occasional and very tolerable.
Like you, my blood work is also in the normal range.
So, around the 3 1/2 month mark, i.e. second week of December, I got Flu A. This lasted a week with a dose of Tamiflu. I highly recommend Tamiflu. During this time, I cut back on my Tecfidera dosing, partly because with the fever, I was out of mind sick and couldn't stomach anything, part of me thinking, wow, I have no immune system to fight this thing. I made sure to take 1 a day, but over the week's time, I missed 4 doses.
Another week goes by...and now it's Christmas and I end up with the stomach flu. I missed a day of dosing then I cut back to 2 additional days of 1 a day. Again, part of my dose reduction was because I could barely eat, part of it was me thinking, geez, I have no immune system to fight this thing despite my blood work being ok. A week later, I finally get strength and energy back.
2 weeks go by...it's now mid-January. I'm sitting at my desk and I'm thinking, I don't feel good. Is that a soar throat coming on???? Yup, sure was...I have had a cold with the cough till I can barely breathe for nearly 4, long, miserable weeks. It took 7 days to ramp up to the cough (dosing stayed on track), 10 days of coughing (dosing 1 per day for 30% of the days), then 7 days to ramp down (dosed 1 per day for 4 days in a row). I really felt that the last round of minimizing my dosing was the straw that broke the virus' back and allowed me to start feeling better.
It is now a week later and I've been full dosing for a week. I woke up 2 days ago with the sniffles. I think this virus is taking hold again because I was home for 3 days prior, so I didn't pick it up somewhere, but I'm also thinking that with my full dosing, my immune system couldn't fight off the final remnants of this virus.
I spoke with my Neuro's office a couple weeks ago to let them know what is going on. At this juncture, they are telling me to not miss my doses. I love my Neuro and I need to talk with him personally, so I will be making an appointment today to discuss the inability to fight off viruses. 4 reactions to viruses in 2 1/2 months is NOT normal for me nor probably, well, anybody! I know this is the medicine for me. I have energy again (even with all this sickness, I don't feel the "exhaustion" of the MS), I have more feeling where I had less, and I can take this medicine. The shots were doing me in...I think there has to be a dosing of this medicine that is right for me. The drug companies have a "formula" for the general population on what works and what doesn't, but isn't life a crap-shoot anyway? I'm wondering if, for me, this amount of medicine is too much and that evidence comes from the last 2 1/2 months of sickness. The strategy is to have this medicine keep the MS at bay without me being more sick from the medicine. I'm not convinced that the current tactics are meeting the strategy.
Wish me luck! And best of luck to you...I hope my experiences help you find what is also best for you.