LSITC, I had bad depression & mental fogginess at about the week mark, was ready to give it up for the feeling-HATED it!! Now, after 2 weeks that fogginess seems to be gone & the depression, well I had depression beforehand-& it seems to b ok now. We'll see. My side effects-GI issues & mental ones-seem to b lessening every day (day 15 today) that I'm gonna stick with it. Good luck to you!