Tysabri rebound?

A board to discuss the newly-released drug Tysabri, (formerly known as Antegren) as a treatment for Multiple Sclerosis

Tysabri rebound?

Postby Ernst » Sat Jul 20, 2013 7:32 am

There is some research data about "tysabri rebound" effect.. but what causes it? Is there any scientific data about it?
My wife's 3 yrs post video: http://www.youtube.com/watch?v=eLeqLps8XR8

Our family: http://www.youtube.com/watch?v=p_QCKxeQAlg
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Re: Tysabri rebound?

Postby HarryZ » Sat Jul 20, 2013 10:33 am

Ernst wrote:There is some research data about "tysabri rebound" effect.. but what causes it? Is there any scientific data about it?


Tysabri is a drug that really plays with your immune system. It can effect MS patients in different ways if one decides to stop using it.
I don't believe they know enough about the mechanism of what happens to really have an answer as yet.

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Re: Tysabri rebound?

Postby NHE » Sat Jul 20, 2013 1:56 pm

Ernst wrote:There is some research data about "tysabri rebound" effect.. but what causes it? Is there any scientific data about it?


Try doing a search for IRIS which is also known as immune reconstitution inflammatory syndrome.
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Re: Tysabri rebound?

Postby NHE » Sun Jul 21, 2013 12:06 am

Ernst wrote:There is some research data about "tysabri rebound" effect.. but what causes it? Is there any scientific data about it?


Here are some journal articles...

Pathology of immune reconstitution inflammatory syndrome in multiple sclerosis with natalizumab-associated progressive multifocal leukoencephalopathy
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259335/

Immune reconstitution inflammatory syndrome in patients with multiple sclerosis following cessation of natalizumab therapy.
http://www.ncbi.nlm.nih.gov/pubmed/20937940

Immune reconstitution inflammatory syndrome in natalizumab-associated PML
http://www.neurology.org/content/77/11/1061.short

Lethal Multiple Sclerosis Relapse After Natalizumab Withdrawal
http://www.ncbi.nlm.nih.gov/pubmed/23100404

These are just a few examples. There are many more.
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