I will not see my neurologist until after the holidays, so I don't yet know what she thinks. It should be interesting. She believes in aggressive treatment.
Your take on combination therapy seems similar to mine. I just wonder what result Biogen was hoping to see in SENTINEL. I mean, would they like to see a narrower differentiation between combination and Avonex. It clearly establishes the independent mode of action, but don't they have to compare across the two studies to make a definitive case for combination? If they are doing this, it sounds like a loser at this point to me. This must be part of their design from the outset. Too bad for Biogen, but I think they will survive. Tysabri is poised to dominate the entire market, not just Avonex's part of it.
Of course, Avonex has a longer history, is a more proven therapy. It just seems to be proven even more mediocre in this latest round of results.
I was struck by your comment that the longer you take Tysabri, the better. I like the sound of that, but why do you think this to be the case?
Anyway, I guess Tysabri is a cannibal. And sometimes I feel like its missionary. Now if I can only find the keys to this boat, my troubles would be over.