i'm biased when it comes to drugs, i don't take any myself. i think people should always get rid of anything they possibly can using nutrition, and only then worry about meds.
if there's a plausible reason why something other than ms is in the picture, docs *should*, but don't, go to that and make sure they rule it out first.
when you mention very healthy and active, as you've seen i immediately think of athletic nutrient depletion. questions jump into my mind about his typical diet and general nutrition regimen. there was someone else on here recently who seems to me to have done themselves in with high exertion levels and low nutritional inputs, here's the link if you want to get at that conversation: post195665.html#p195665
now for that seizing you mention. suspect #1 is magnesium. low in ms, low levels result in spasticity. i have experience with a mag deficiency seize, but fun fun fun mine was in my throat, while swallowing and airway was blocked. if you go to my regimen 'ms nutrition' you can read up on the details for proper testing, diet and supplement options to improve serum magnesium. there are links to blood pressure and magnesium too:
Serum Magnesium and Plasma Sodium Levels in Essential Vascular Hypertension (1958)http://circ.ahajournals.org/content/17/4/761.short
"...mean serum magnesium concentration in 26 uncomplicated hypertensive patients was found to be significantly lower than that in 43 normal individuals."
isn't it neat how this research is over 50 years old and yet no doctors have mentioned magnesium replacement to your athletic hubby??
Magnesium deficiency and hypertension: correlation between magnesium-deficient diets and microcirculatory changes in situ (1984)http://www.sciencemag.org/content/223/4 ... 5.abstract
Rats maintained for 12 weeks on diets moderately or more severely deficient in magnesium showed significant elevations in arterial blood pressure compared to control animals. ... The greater the degree of dietary magnesium deficiency the greater the reductions in microvascular lumen sizes. These findings may provide a rationale for the etiology, as well as treatment, of some forms of hypertensive vascular disease.
Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: The aric study (1995)http://www.jclinepi.com/article/0895-4356(94
The objective of this study was to examine the relationships of serum and dietary magnesium (Mg) with prevalent cardiovascular disease (CVD), hypertension, diabetes mellitus, fasting insulin, and average carotid intimal-medial wall thickness measured by B-mode ultrasound. ... A total of 15,248 participants took part, male and female, black and white, aged 45–64 years. ... Mean serum Mg levels were significantly lower in participants with prevalent CVD, hypertension, and diabetes than in those free of these diseases. ... Dietary Mg intake was inversely associated with fasting serum insulin, plasma high density lipoprotein-cholesterol, systolic and diastolic blood pressure. ... In conclusion, low serum and dietary Mg may be related to the etiologies of CVD, hypertension, diabetes, and atherosclerosis.
i have this one stupid study that showed magnesium supplementing didn't affect high blood pressure so it's not a useful therapy. http://www.ncbi.nlm.nih.gov/pmc/article ... 8-0007.pdf
hogwash, i say
when you look at the study, the average serum magnesium level to start is 0.89 mmol/L. then they gave the participants this micro dose, and by the end of the study the levels barely inched up to 0.91 mmol/L, and that was just the average, half the study participants were still 0.90 or lower. so no wonder they didn't see improvement. you want to be 0.91 at an absolute minimum, even though the so-called 'normal' range is 0.70-1.10 mmol/L.
now to the idea of mini-strokes. it's magnesium again. here's a charming study where they looked at magnesium levels in stroke:
Early Clinical and Radiological Predictors of Fatal Brain Swelling in Ischemic Strokehttp://stroke.ahajournals.org/content/30/2/287.full
here's the table that has the serum data:http://stroke.ahajournals.org/content/3 ... nsion.html
here's the table that shows the patients' pre-existing conditions, all of which have strong links to magnesium status too, not surprisingly...:http://stroke.ahajournals.org/content/3 ... nsion.html
the study group are the patients that died, the controls also had a severe stroke but lived. both groups had serum magnesium levels averaging 0.85 mmol/L. once again 'normal', but it's in the bottom end of the curve, when you want to be up more in the 0.95 neck of the woods.
so the good news is that serum magnesium is an easy test, it should be relatively easy to boost dietary magnesium intakes, add things like epsom salts (magnesium sulfate) baths into the regimen, and consider good quality bioavailable magnesium supplements, eg magnesium glycinate or similar. consider that the blood pressure meds and when it works hopefully the neuro will be appeased.
low vit D3 also points to magnesium, and you should probably also have the serum zinc test done. it's a good idea to get the kids tested for sure. but don't test vit d3 alone. your ability to utilize d3 supplements is dependent on magnesium and zinc, and once you have enough d3 in your system you'll be better able to absorb calcium too. the docs have only recently flagged on the d3 aspect of ms, and i'm pretty sure most don't get the magnesium and zinc links yet. so, to make sure you actually get your money's worth out of that d3, make sure your magnesium and zinc status is optimized. also, note that you need to take some magnesium at the same time as d3, but you definitely need to take some at a separate time also.
oh and by the way stress depletes magnesium, which is also associated with migraine
there's an ms caregiver here, cheerleader, who has used nutrition to reverse her issues with migraine, you might want to have a chat with her about that.
once again, that link to my nutrition regimen thread, with lots of info for targeting health, applicable to ms and lots of other conditions. post195665.html#p195665
hope that helps
there are lots of other folks on here who will have plenty to contribute. if you have any questions, fire away